Patent US4780320A successfully refreshed from Google Patents.
US4780320A
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US
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Controlled release drug delivery system for the periodontal pocket
Assignee: PHARMETRIX Inc
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Filing: 1986-04-29
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Granted: 1988-10-25
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Expires: 2006-04-29
Abstract
Abstract A controlled release drug delivery system for placement in the periodontal pocket. The system comprises a plurality of drug-containing microparticles or microcapsules, between 10 and 500 microns in size, suspended in a pharmaceutically acceptable carrier medium, and is capable of maintaining an effective level of drug in the periodontal pocket for a period of 1 to 30 days.
Inventors
- 👤 Richard W. Baker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 09:55
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K6/00; A61K6/15; A61K6/17; A61K6/30; A61K6/60; A61K6/69; A61K9/0012; A61K9/0053; A61K9/0063; A61K9/1641; A61K9/1647
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
66 words
A controlled release drug delivery system for placement in a periodontal pocket, comprising: (a) a plurality of discrete microparticles comprising a drug-containing polymer and the drug contained therein, said microparticles being between 10 and 500 microns in diameter, and (b) a fluid suspending medium for said microparticles; said drug delivery system remaining active in the periodontal pocket for a period of between one and 30 days.
Claim 2
Dependent Claim
66 words
A controlled release drug delivery system for placement in a periodontal pocket, comprising: (a) a plurality of discrete microparticles comprising a drug-containing polymer and the drug contained therein, said microparticles being between 10 and 500 microns in diameter, and (b) a fluid suspending medium for said microparticles; said drug delivery system remaining active in the periodontal pocket for a period of between one and 30 days.
Claim 3
Dependent Claim
23 words
The delivery system of claim 1, wherein the drug is selected from the group consisting of antimicrobial drugs, anti-inflammatory drugs and local anaesthetics.
Claim 4
Dependent Claim
12 words
The delivery system of claim 1, wherein the drug is an antibiotic.
Claim 5
Dependent Claim
21 words
The delivery system of claim 1, wherein the drug is chosen from the group consisting of tetracycline, its compounds and derivatives.
Claim 6
Dependent Claim
21 words
The delivery system of claim 1, wherein the drug is chosen from the group consisting of chlorhexidine, its compounds and derivatives.
Claim 7
Dependent Claim
11 words
The delivery system of claim 1, wherein the drug is flurbiprofen.
Claim 8
Dependent Claim
27 words
The delivery system of claim 1, wherein said drug-containing polymer is chosen from the group consisting of cellulose acetate, ethylcellulose, polystyrene, polysulfone, polycarbonate and lacticglycolic acid copolymers.
Claim 9
Dependent Claim
12 words
The delivery system of claim 1, wherein said drug-containing polymer is polycarbonate.
Claim 10
Dependent Claim
20 words
The delivery system of claim 1, wherein said drug-containing polymer is chosen from the group consisting of lacticglycolic acid copolymers.
Claim 11
Dependent Claim
19 words
The delivery system of claim 1, wherein the fluid suspending medium has a viscosity of at least 1000 centipoise.
Claim 12
Dependent Claim
46 words
The delivery system of claim 1, wherein the fluid suspending medium is a thermally gelling fluid, said fluid having a sol/gel transition temperature between 25° and 40° C. and being a free-flowing liquid below the transition temperature and a thickened non-flowing gel above the transition temperature.
Claim 13
Independent Claim
72 words
A method for treating periodontal disease comprising inserting into a periodontal pocket a controlled release drug delivery system comprising: (a) a plurality of discrete microparticles comprising a drug-containing polymer and the drug contained therein, said microparticles being between 10 and 500 microns in diameter, and (b) a fluid suspending medium for said microparticles; said drug delivery system remaining active in the periodontal pocket for a period of between one and 30 days.
Claim 14
Independent Claim
72 words
A method for treating periodontal disease comprising inserting into a periodontal pocket a controlled release drug delivery system comprising: (a) a plurality of discrete microparticles comprising a drug-containing polymer and the drug contained therein, said microparticles being between 10 and 500 microns in diameter, and (b) a fluid suspending medium for said microparticles; said drug delivery system remaining active in the periodontal pocket for a period of between one and 30 days.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-25 | 1992-04-25 | 1992-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-25 | 1996-04-25 | 1996-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-25 | 2000-04-25 | 2000-10-25 | $7700.00 | Window Closed / Lapsed |