US4369172A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose
Assignee: Forest Laboratories LLC
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Filing: 1981-12-18
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Granted: 1983-01-18
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Expires: 2001-12-18
Abstract
Abstract A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a regular and prolonged release pattern upon administration, the carrier base material being hydroxypropylmethylcellulose or a mixture of hydroxypropylmethylcellulose and up to 30% by weight of the mixture of ethylcellulose and/or up to 30% by weight of the mixture of sodium carboxymethylcellulose, and wherein the hydroxypropylmethylcellulose has a hydroxypropoxyl content of 9-12 weight % and a number average molecular weight of less than 50,000.
Inventors
- 👤 Joseph M. Schor
- 👤 Ashok Nigalaye
- 👤 Norman G. Gaylord
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 14:52
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2054
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
84 words
A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a regular and prolonged release pattern upon administration, the carrier base material being hydroxypropylmethylcellulose or a mixture of hydroxypropylmethylcellulose and up to 30% by weight of the mixture of ethylcellulose and/or up to 30% by weight of the mixture of sodium carboxymethylcellulose, and wherein the hydroxypropylmethylcellulose has a hydroxypropoxyl content of 9-12 weight-% and a number average molecular weight of less than 50,000.
Claim 2
Dependent Claim
84 words
A carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a regular and prolonged release pattern upon administration, the carrier base material being hydroxypropylmethylcellulose or a mixture of hydroxypropylmethylcellulose and up to 30% by weight of the mixture of ethylcellulose and/or up to 30% by weight of the mixture of sodium carboxymethylcellulose, and wherein the hydroxypropylmethylcellulose has a hydroxypropoxyl content of 9-12 weight-% and a number average molecular weight of less than 50,000.
Claim 3
Dependent Claim
21 words
A composition according to claim 1 in which the carrier base material consists of a mixture of hydroxypropylmethylcellulose and 0-30% ethylcellulose.
Claim 4
Dependent Claim
22 words
A composition according to claim 1 in which the carrier base material consists of a mixture of hydroxypropylmethylcellulose and 0-30% sodium carboxymethylcellulose.
Claim 5
Dependent Claim
26 words
A composition according to claim 1 in which the active medicament is an antacid selected from the group consisting of aluminum trisilicate, aluminum hydroxide and cimetidine.
Claim 6
Dependent Claim
30 words
A composition according to claim 1 in which the active medicament is an anti-inflammatory selected from the group consisting of phenylbutazone, indomethacin, naproxen, ibuprofen, flurbiprofen, diclofenac, dexamethasone, prednisone and prednisolone.
Claim 7
Dependent Claim
28 words
A composition according to claim 1 in which the active medicament is a coronary dilator selected from the group consisting of glyceryl trinitrate, isosorbide dinitrate and pentaerythritol tetranitrate.
Claim 8
Dependent Claim
27 words
A composition according to claim 1 in which the active medicament is a peripheral vasodilator selected from the group consisting of naftidrofuryl oxalate, cyclandelate and nicotinic acid.
Claim 9
Dependent Claim
35 words
A composition according to claim 1 in which the active medicament is an anti-infective selected from the group consisting of erythromycin stearate, cephalexin, nalidixic acid, tetracycline hydrochloride, ampicillin, flucloxacillin sodium, hexamine mandelate and hexamine hippurate.
Claim 10
Dependent Claim
39 words
A composition according to claim 1 in which the active medicament is a psychotropic selected from the group consisting of fluazepam, diazepam, amitryptyline, doxepin, thioridazine, trifluperazine, fluphenazine, piperothiazine, haloperidol, maprotiline hydrochloride, imipramine, desmethylimipramine, lithium carbonate, lithium sulfate and methylphenidate.
Claim 11
Dependent Claim
27 words
A composition according to claim 1 in which the active medicament is a central stimulant selected from the group consisting of isoproterenol, amphetamne sulfate and amphetamine hydrochloride.
Claim 12
Dependent Claim
24 words
A composition according to claim 1 in which the active medicament is an antihistamine selected from the group consisting of chlorpheniramine, bropheniramine and diphenhydramine.
Claim 13
Dependent Claim
27 words
A composition according to claim 1 in which the active medicament is a laxative selected from the group consisting of bisacodyl, magnesium hydroxide and dioctyl sodium sulfosuccinate.
Claim 14
Dependent Claim
23 words
A composition according to claim 1 in which the active medicament is a decongestant selected from the group consisting of phenylpropanolamine and pseudoephedrine.
Claim 15
Dependent Claim
27 words
A composition according to claim 1 in which the active medicament is a vitamin substance selected from the group consisting of alphatocopherol, thiamine, pyridoxine and ascorbic acid.
Claim 16
Dependent Claim
25 words
A composition according to claim 1 in which the active medicament is a gastrointestinal sedative selected from the group consisting of propantheline bromide and metoclorpramide.
Claim 17
Dependent Claim
16 words
A composition according to claim 1 in which the active medicament is diphenoxylate, an anti-diarrheal preparation.
Claim 18
Dependent Claim
30 words
A composition according to claim 1 in which the active medicament is a cerebral vasodilator selected from the group consisting of soloctidilum, naftidrofuryl oxalate, co-dergocrine mesylate, papaverine and naftidrofuryl oxalate.
Claim 19
Dependent Claim
31 words
A composition according to claim 1 in which the active medicament is an anti-anginal preparation selected from the group consisting of isosorbide dinitrate, pentaerythritol tetranitrate, verapamil, nifedepine, diltiazem and glyceryl trinitrate.
Claim 20
Dependent Claim
32 words
A composition according to claim 1 in which the active medicament is an antiarrythmic selected from the group consisting of verapamil, nifedepine, diltiazem, disopyramide, bretylium tosylate, quinidine sulfate, quinidine gluconate and procainamide.
Claim 21
Dependent Claim
29 words
A composition according to claim 1 in which the active medicament is an antihypertensive selected from the group consisting of guanethidine monosulphate, methyldopa, oxprenolol hydrochloride, captopril, hydralazine and propranolol.
Claim 22
Dependent Claim
21 words
A composition according to claim 1 in which the active medicament is ergotamine, a vasoconstrictor used in the treatment of migraine.
Claim 23
Dependent Claim
30 words
A composition according to claim 1 in which the active medicament is a substance which influences blood coagulability selected from the group consisting of protamine sulfate and epsilon aminocaproic acid.
Claim 24
Dependent Claim
38 words
A composition according to claim 1 in which the active medicament is an analgesic selected from the group consisting of acetaminophen, acetylsalicylic acid, oxycodeinone, morphine, heroin, nalbuphine, butorphanol tartrate, pentazocine hydrochloride, cyclazacine, pethidine, byprenorphine, scopolamine and mefenamic acid.
Claim 25
Dependent Claim
25 words
A composition according to claim 1 in which the active medicament is a hypnotic selected from the group consisting of dichloral phenazone, nitrazepam and temazepam.
Claim 26
Dependent Claim
24 words
A composition according to claim 1 in which the active medicament is an antinauseant selected from the group consisting of chlorpromazine and promethazine theoclate.
Claim 27
Dependent Claim
25 words
A composition according to claim 1 in which the active medicament is an anticonvulsant selected from the group consisting of sodium valproate and phenytoin sodium.
Claim 28
Dependent Claim
19 words
A composition according to claim 1 in which the active medicament is a neuromuscular drug such as dantrolene sodium.
Claim 29
Dependent Claim
26 words
A composition according to claim 1 in which the active medicament is a hypoglycemic agent selected from the group consisting of diabenase, glucagon, tolbutamide and insulin.
Claim 30
Dependent Claim
30 words
A composition according to claim 1 in which the active medicament is a drug used in treating thyroid gland disorders selected from the group consisting of thyroxine, triiodothyronine and propylthiouracil.
Claim 31
Dependent Claim
26 words
A composition according to claim 1 in which the active medicament is a diuretic selected from the group consisting of furosemide, chlorthalidone, hydrochlorthiazide, spironolactone and triampterene.
Claim 32
Dependent Claim
17 words
A composition according to claim 1 in which the active medicament is the uterine relaxant medicament, ritodrine.
Claim 33
Dependent Claim
27 words
A composition according to claim 1 in which the active medicament is an appetite suppressant selected from the group consisting of phentermine, diethylproprion hydrochloride and fenfluramine hydrochloride.
Claim 34
Dependent Claim
28 words
A composition according to claim 1 in which the active medicament is an erythropoietic substance selected from the group consisting of folic acid, calcium gluconate and ferrous sulphate.
Claim 35
Dependent Claim
29 words
A composition according to claim 1 in which the active medicament is an antiasthmatic drug selected from the group consisting of aminophylline, theophylline, orciprenaline sulphate, terbutaline sulphate and salbutamol.
Claim 36
Dependent Claim
23 words
A composition according to claim 1 in which the active medicament is an expectorant selected from the group consisting of carbocisteine and guaiphenesin.
Claim 37
Dependent Claim
32 words
A composition according to claim 1 in which the active medicament is a cough suppressant selected from the group consisting of noscapine, codeine phosphate, codeine sulfate, oxycodone, dihydrocodeine tartrate, oxycodeinone and dextromethorphan.
Claim 38
Dependent Claim
25 words
A composition according to claim 1 in which the active medicament is an antiuricemic drug selected from the group consisting of allopurinol, probenecid and sulphinpyrazone.
Claim 39
Dependent Claim
25 words
A composition according to claim 1 in which the active medicament is an antiseptic selected from the group consisting of cetylpyridinium chloride, tyrothricin and chlorhexidine.
References Cited (Backward Citations)
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US4091205A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-17 | 1986-07-19 | 1987-01-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-17 | 1990-07-19 | 1991-01-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-17 | 1994-07-19 | 1995-01-18 | $7700.00 | Window Closed / Lapsed |