Patent US6569489B1 successfully refreshed from Google Patents.
US6569489B1
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US
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Bioactive ceramic coating and method
Assignee: DePuy Products Inc
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Filing: 2000-05-19
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Granted: 2003-05-27
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Expires: 2020-05-19
Abstract
Abstract A bioactive bone mineral carbonated nano-crystalline apatite is chemically bonded to a variety of substrates, including implantable prostheses. This coating is applied uniformly to substrate surfaces of varying geometry and surface textures. It is firmly secured to the substrate and encourages rapid and effective bone ingrowth. The coating is applied by immersing the substrate in an aqueous solution containing calcium, phosphate and carbonate ions. Other ions, such as sodium, potassium, magnesium, chloride, sulfate, and silicate, may optionally be present in the solution. The solution is exposed in a controlled environment when it reacts with the substrate to form the coating.
Inventors
- 👤 Panjian Li
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 21:52
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/30; A61L27/32; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/02; A61L27/025; A61L27/04; A61L27/14; A61L27/16; A61L27/18; A61F2310/00; A61F2310/00389; A61F2310/00592; A61F2310/00796
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
101 words
A process for forming a synthetic crystalline apatite coating on a substrate, comprising the steps of: providing a substrate; providing an aqueous solution comprising calcium ions, phosphate ions, and carbonate ions having an initial pH level in the range of 6.0 to 7.5 and a temperature less than or equal to 100° C.; and immersing at least a portion of the substrate in the aqueous solution for an amount of time sufficient to form a synthetic crystalline apatite ceramic coating and effect the chemical bonding of the coating to the substrate, while the aqueous solution maintains a pH level below 8.0.
Claim 2
Dependent Claim
101 words
A process for forming a synthetic crystalline apatite coating on a substrate, comprising the steps of: providing a substrate; providing an aqueous solution comprising calcium ions, phosphate ions, and carbonate ions having an initial pH level in the range of 6.0 to 7.5 and a temperature less than or equal to 100° C.; and immersing at least a portion of the substrate in the aqueous solution for an amount of time sufficient to form a synthetic crystalline apatite ceramic coating and effect the chemical bonding of the coating to the substrate, while the aqueous solution maintains a pH level below 8.0.
Claim 3
Dependent Claim
42 words
The process of claim 1 wherein the aqueous solution is exposed in a controlled environment where sufficient carbon dioxide is maintained in the atmosphere above the aqueous immersion solution, such that the pH of the solution is maintained at or below 7.5.
Claim 4
Dependent Claim
58 words
The process of claim 1 wherein the calcium ions are present at a concentration in the range of about 1-10 mM, the magnesium ions are present at about 0.1-8 mM, the phosphate ions are present at a concentration in the range of about 0.50-5 mM, and the carbonate ions are present in the range of about 1-50 mM.
Claim 5
Dependent Claim
27 words
The process of claim 1 wherein the aqueous solution further comprises ions selected from the group consisting of sodium, potassium, magnesium, chlorine, sulfate, silicate and mixtures thereof.
Claim 6
Dependent Claim
41 words
The process of claim 4 wherein the sodium ions are present at about 100-200 mM, the potassium ions are present at 2-8 mM, the chlorine ions are present at about 100-250 mM, and the sulfate ions are present at 0-1.5 mM.
Claim 7
Dependent Claim
23 words
The process of claim 1 , wherein the synthetic crystalline apatite ceramic coating has a thickness in the range of about 0.005-50 μm.
Claim 8
Dependent Claim
21 words
The process of claim 1 , wherein the substrate is selected from the group consisting of metals, ceramics, silicon, and polymers.
Claim 9
Dependent Claim
22 words
The process of claim 1 wherein the apatite ceramic is a dense coating, having a crystal size less than about 1 μm.
Claim 10
Dependent Claim
22 words
The process of claim 1 , wherein a surface texture of the substrate and a surface geometry of the substrate are preserved.
Claim 11
Dependent Claim
34 words
The process of claim 1 wherein the apatite ceramic coating includes a carbonated crystalline apatite that is substantially devoid of hydroxyl groups in its crystal structure, the carbonated crystalline apatite containing chemically adsorbed water.
Claim 12
Dependent Claim
39 words
The process of claim 1 wherein the pH of the aqueous solution is in the range of about 6.7 to 7.4 and the temperature of the aqueous solution is in the range of about 30° C. to 50° C.
Claim 13
Dependent Claim
195 words
A process for growing a synthetic bone mineral carbonated crystalline apatite coating on a substrate, comprising the steps of: providing a substrate; preparing an aqueous solution comprising calcium ions, phosphate ions, carbonate ions and magnesium ions, the aqueous solution being transparent and having an initial pH level in the range of about 6.0 to 7.5 and a temperature in the range of about 20° C. to 60° C.; and contacting the substrate with the aqueous solution by soaking at least a portion of the substrate in the aqueous solution and allowing the aqueous solution to react with the substrate, wherein the initial pH level of the aqueous solution increases to an increased pH level less than pH 8.0 as the aqueous solution begins to react with the substrate and the increased pH level decreases as a film of synthetic carbonated crystalline apatite coating begins to grow on at least the portion of the substrate in contact with the aqueous solution to yield a synthetic carbonated crystalline apatite coating formed on the substrate that is substantially devoid of hydroxyl groups, includes chemically adsorbed water, and is chemically bonded to at least a portion of the substrate.
Claim 14
Dependent Claim
195 words
A process for growing a synthetic bone mineral carbonated crystalline apatite coating on a substrate, comprising the steps of: providing a substrate; preparing an aqueous solution comprising calcium ions, phosphate ions, carbonate ions and magnesium ions, the aqueous solution being transparent and having an initial pH level in the range of about 6.0 to 7.5 and a temperature in the range of about 20° C. to 60° C.; and contacting the substrate with the aqueous solution by soaking at least a portion of the substrate in the aqueous solution and allowing the aqueous solution to react with the substrate, wherein the initial pH level of the aqueous solution increases to an increased pH level less than pH 8.0 as the aqueous solution begins to react with the substrate and the increased pH level decreases as a film of synthetic carbonated crystalline apatite coating begins to grow on at least the portion of the substrate in contact with the aqueous solution to yield a synthetic carbonated crystalline apatite coating formed on the substrate that is substantially devoid of hydroxyl groups, includes chemically adsorbed water, and is chemically bonded to at least a portion of the substrate.
Claim 15
Dependent Claim
68 words
The process of claim 12 , wherein the aqueous solution further comprises a buffering component selected from the group consisting of tris(hydroxymethyl)aminomethane, hydrochloric acid, and combinations thereof, the buffering component being effective to maintain the pH level of the aqueous solution at or below 7.5 and to control a rate at which the pH level of the aqueous solution changes as the aqueous solution reacts with the substrate.
Claim 16
Dependent Claim
45 words
The process of claim 13 , wherein the tris(hydroxymethyl)aminomethane is present in the aqueous solution at a concentration in the range of about 5-100 mM and the hydrochloric acid is present in the aqueous solution at a concentration in the range of about 5-90 mM.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-05-26 | 2006-11-25 | 2007-05-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-05-26 | 2010-11-25 | 2011-05-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-05-26 | 2014-11-25 | 2015-05-27 | $7700.00 | Window Closed / Lapsed |