Patent US7113917B2 successfully refreshed from Google Patents.
US6207218B1
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Method for coating medical implants
Assignee: Isotis BV
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Filing: 1999-07-12
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Granted: 2001-03-27
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Expires: 2019-07-12
Abstract
Abstract The present invention relates to a method for coating a medical implant, wherein the implant is submersed in an aqueous solution of magnesium, calcium and phosphate ions through which a gaseous weak acid is passed, the solution is degassed, and the coating is allowed to precipitate onto the implant. The invention further relates to a medical implant coated in said method and to a device for use in said method.
Inventors
- 👤 Pierre Jean François Layrolle
- 👤 Klaas de Groot
- 👤 Joost Dick De Bruijn
- 👤 Clemens A. van Blitterswijk
- 👤 Yuan Huipin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 03:19
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/30; A61L27/32; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30767; A61L31/00; A61L31/08; A61L31/082; A61L31/086; A61F2/3094; Y; Y10; Y10S; Y10S977/00; Y10S977/84; Y10S977/849; Y10S977/855; Y10S977/857
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
66 words
A method for coating an implant comprising the steps of (a) contacting the implant with an aqueous solution of magnesium, calcium, and phosphate ions; (b) passing a gaseous weak acid through the aqueous solution to maintain a concentrated solution of the ions; then (c) degassing the aqueous solution to cause the magnesium, calcium, and phosphate ions to precipitate onto the implant to form a coated implant.
Claim 2
Independent Claim
66 words
A method for coating an implant comprising the steps of (a) contacting the implant with an aqueous solution of magnesium, calcium, and phosphate ions; (b) passing a gaseous weak acid through the aqueous solution to maintain a concentrated solution of the ions; then (c) degassing the aqueous solution to cause the magnesium, calcium, and phosphate ions to precipitate onto the implant to form a coated implant.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein the gaseous weak acid is carbon dioxide.
Claim 4
Dependent Claim
21 words
The method of claim 1 wherein the implant is formed from one or more of metal, organic material, polymer or ceramic.
Claim 5
Dependent Claim
29 words
The method according to claim 1 wherein the calcium and phosphate ions are present in the aqueous solution in a molar ratio of between about 1 to about 3.
Claim 6
Dependent Claim
29 words
The method according to claim 1 wherein the calcium and phosphate ions are present in the aqueous solution in a molar ratio of between about 1.5 to about 2.5.
Claim 7
Dependent Claim
28 words
The method according to claim 1 wherein the aqueous solution comprises about 0.5 to about 50 mM calcium ions and about 0.5 to about 20 mM phosphate ions.
Claim 8
Dependent Claim
28 words
The method according to claim 1 wherein the aqueous solution comprises about 2.5 to about 25 mM calcium ions and about 1.0 to about 10 mM phosphate ions.
Claim 9
Dependent Claim
19 words
The method according to claim 1 wherein the aqueous solution comprises about 0.1 to about 20 mM magnesium ions.
Claim 10
Dependent Claim
19 words
The method according to claim 1 wherein the aqueous solution comprises about 1.5 to about 10 mM magnesium ions.
Claim 11
Dependent Claim
22 words
The method according to claim 1 wherein the aqueous solution comprises no carbonate ions or less than about 50 mM carbonate ions.
Claim 12
Dependent Claim
23 words
The method according to claim 1 wherein the aqueous solution comprises no carbon ate ions or less than about 42 mM carbonate ions.
Claim 13
Dependent Claim
24 words
The method according to claim 1 wherein the aqueous solution comprises an ionic strength in the range of about 0.1 to about 2 M.
Claim 14
Dependent Claim
24 words
The method according to claim 1 wherein the aqueous solution comprises an ionic strength in the range of about 0.15 to about 1.5 M.
Claim 15
Dependent Claim
27 words
The method according to claim 1 wherein the gaseous weak acid is passed through the aqueous solution at a pressure of about 0.1 to about 10 bar.
Claim 16
Dependent Claim
27 words
The method according to claim 1 wherein the gaseous weak acid is passed through the aqueous solution at a pressure of about 0.5 to about 1.5 bar.
Claim 17
Dependent Claim
25 words
The method according to claim 1 wherein the aqueous solution has a temperature in the range of between about 5° C. to about 80° C.
Claim 18
Dependent Claim
25 words
The method according to claim 1 wherein the aqueous solution has a temperature in the range of between about 5° C. to about 50° C.
Claim 19
Dependent Claim
27 words
The method according to claim 1 wherein the implant is treated by a mechanical or chemical surface treatment prior to contacting the implant with the aqueous solution.
Claim 20
Dependent Claim
16 words
The method of claim 18 wherein the implant is treated by sand-blasting, scoring, polishing or grounding.
Claim 21
Dependent Claim
27 words
The method of claim 18 wherein the implant is treated by contacting with strong mineral acid or an oxidizing agent in a manner to etch the implant.
Claim 22
Dependent Claim
33 words
The method of claim 1 wherein the coating comprises magnesium ions, calcium ions and phosphate ions and one or more ions selected from the group consisting of hydroxide, carbonate, chloride, sodium and potassium.
Claim 23
Dependent Claim
32 words
The method of claim 1 wherein the coating comprises one or more of amorphous carbonate calcium phosphate, hydroxyapatite, calcium deficient and hydroxyl carbonate apatite, oroctacalcium phosphate, dicalcium phosphate dihydrate or calcium carbonate.
Claim 24
Dependent Claim
18 words
The method of claim 1 wherein the coating has a thickness of about 0.5 to about 100 microns.
Claim 25
Dependent Claim
18 words
The method of claim 1 wherein the coating has a thickness of about 0.5 to about 50 microns.
Claim 26
Dependent Claim
39 words
The method of claim 1 further comprising the step of contacting the coated implant with a calcifying solution comprising calcium and phosphate ions, and allowing a precipitate layer of calcium and phosphate ions to form on the coated implant.
References Cited (Backward Citations)
US5141576A
Cited
EP0389713B1
Cited
US5068122A
Cited
US5164187A
Cited
US5188670A
Cited
EP0450939A2
Cited
US5338772A
Cited
WO1993007912A1
Cited
WO1995013101A1
Cited
EP0678300A1
Cited
JPH0840711A
Cited
CA2205107A1
Cited
EP0806212A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2004-03-26 | 2004-09-25 | 2005-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2008-03-26 | 2008-09-25 | 2009-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2012-03-26 | 2012-09-25 | 2013-03-27 | $7700.00 | Window Closed / Lapsed |