US6136369A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device for incorporation and release of biologically active agents
Assignee: Chienna BV
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Filing: 1999-04-23
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Granted: 2000-10-24
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Expires: 2019-04-23
Abstract
Abstract The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprepitation of the biologically active substance.
Inventors
- 👤 Eugenia Ribeiro de Sousa Fidalgo Leitao
- 👤 Joost Dick De Bruijn
- 👤 Hai-Bo Wen
- 👤 Klaas de Groot
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 21:55
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/54; A61F; A61F2/00; A61F2/02; A61F2/30; A61F2/30767; A61L27/28; A61L27/30; A61L27/32; A61F2002/30001; A61F2002/30667; A61F2002/30677; A61F2002/30906; A61F2310/00; A61F2310/00005; A61F2310/00011; A61F2310/00023; A61F2310/00179; A61F2310/00389; A61F2310/00592; A61F2310/00796; A61F2310/0097; A61F2310/00976; A61L2300/00; A61L2300/20; A61L2300/22; A61L2300/23; A61L2300/232; A61L2300/252; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414; A61L2300/416; A61L2300/43; A61L2300/60; A61L2300/606
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
69 words
A process for producing a calcium phosphate coated implantable device, comprising subjecting a porous or non-porous material to a surface treatment until a precipitate enhancing roughened surface with an average peak distance between 10 nm and about 1,000 nm is obtained, and subsequently subjecting the surface to precipitation from a solution to form a coating, with the coating comprising calcium ions, phosphate ions, and an organic biologically active agent.
Claim 2
Dependent Claim
69 words
A process for producing a calcium phosphate coated implantable device, comprising subjecting a porous or non-porous material to a surface treatment until a precipitate enhancing roughened surface with an average peak distance between 10 nm and about 1,000 nm is obtained, and subsequently subjecting the surface to precipitation from a solution to form a coating, with the coating comprising calcium ions, phosphate ions, and an organic biologically active agent.
Claim 3
Dependent Claim
15 words
The process according to claim 1, wherein the solution has a pH of about 4-10.
Claim 4
Dependent Claim
30 words
The process according to claim 1, wherein the biologically active agent is selected from the group consisting of growth factors, lipids, (lipo)polysaccaharides, hormones, cytostatic agents, antibiotics, proteins, and mixtures thereof.
Claim 5
Dependent Claim
19 words
The process according to claim 1, wherein said subjecting the surface to precipitation is carried out in two stages.
Claim 6
Dependent Claim
24 words
A process according to claim 1 comprising treating titanium or a titanium alloy with an acid solution followed by immersion in an alkaline solution.
Claim 7
Dependent Claim
21 words
A process according to claim 1 comprising treating porous tantalum with an acid solution followed by immersion in an oxidizing solution.
Claim 8
Dependent Claim
15 words
A process according to claim 2 wherein the pH is about 6 to about 8.
Claim 9
Dependent Claim
25 words
A process according to claim 1, wherein the biologically active agents in the implantable device comprise up to 60 percent by weight of the coating.
Claim 10
Dependent Claim
17 words
A process according to claim 1, wherein the coating is degradable due to a solution mediated process.
Claim 11
Dependent Claim
17 words
A process according to claim 1, wherein the coating is degradable due to a cell mediated process.
Claim 12
Dependent Claim
15 words
A process according to claim 1, wherein the biologically active agent comprises an osteoinductive protein.
References Cited (Backward Citations)
US4330891A
Cited
US4746532A
Cited
US4847163A
Cited
US5205921A
Cited
US5478237A
Cited
US5947893A
Cited
US5603338A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-10-24 | 2004-04-24 | 2004-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-10-24 | 2008-04-24 | 2008-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-10-24 | 2012-04-24 | 2012-10-24 | $7700.00 | Window Closed / Lapsed |