US5612049A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bioactive coatings and their preparation and use
Assignee: Vivoxid Oy
•
Filing: 1993-04-21
•
Granted: 1997-03-18
•
Expires: 2013-04-21
Abstract
Abstract Novel coating materials for biomedical applications, particularly for use on biomedical implants, the coating material containing gel-derived titania where the material is capable of inducing calcium phosphate formation onto its surface under in vitro conditions, e.g. in a simulated body fluid and/or under in vivo conditions, processes for the preparation of the coating materials as well as their use in biomedical implant technology.
Inventors
- 👤 Panjian Li
- 👤 Ilkka Kangasniemi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 21:42
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/30; A61L27/32; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61L27/02; A61L27/04; A61L27/06; A61L27/306; A61L27/50; A61L27/54; A61F2310/00; A61F2310/00389; A61F2310/00592; A61F2310/00796; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/60; A61L2300/606; A61L2430/00; A61L2430/12; A61L2430/24
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
68 words
A process for the preparation of a coating material for the use on biomedical implants wherein a gel-derived titania-based coating is formed according to a sol-gel method and then treated at an elevated temperature of at least 350° C., such that said coating material induces calcium phosphate formation onto its surface under at least one condition of the group consisting of in vitro conditions and in vivo conditions.
Claim 2
Dependent Claim
68 words
A process for the preparation of a coating material for the use on biomedical implants wherein a gel-derived titania-based coating is formed according to a sol-gel method and then treated at an elevated temperature of at least 350° C., such that said coating material induces calcium phosphate formation onto its surface under at least one condition of the group consisting of in vitro conditions and in vivo conditions.
Claim 3
Dependent Claim
67 words
A process for the preparation of a coating material for use on biomedical implants wherein a gel-derived titania-based coating is formed according to a galvanic method and then treated at an elevated temperature of at least 350° C., such that said coating material induces calcium phosphate formation onto its surface under at least one condition of the group consisting of in vitro conditions and in vivo conditions.
Claim 4
Dependent Claim
67 words
A process for the preparation of a coating material for use on biomedical implants wherein a gel-derived titania-based coating is formed according to a galvanic method and then treated at an elevated temperature of at least 350° C., such that said coating material induces calcium phosphate formation onto its surface under at least one condition of the group consisting of in vitro conditions and in vivo conditions.
Claim 5
Dependent Claim
29 words
A process according to claim 2 wherein the process is carried out in a hydroxide solution where titanium is used as the positive as well as the negative pole.
Claim 6
Dependent Claim
46 words
A process according to claim 1 wherein one or more of the following oxides are added to the process: CaO, P 2 O 5 , Na 2 O, SiO 2 , K 2 O, Al 2 O 3 , MgO or B 2 O 3 .
Claim 7
Dependent Claim
56 words
A coating composition for biomedical implants comprising mainly a gel-derived titania-based material that has been treated at elevated temperature wherein said material induces calcium phosphate formation onto its surface under at least one condition of the group consisting of in vitro conditions and in vivo conditions, and wherein said elevated temperature is at least 350° C.
Claim 8
Dependent Claim
56 words
A coating composition for biomedical implants comprising mainly a gel-derived titania-based material that has been treated at elevated temperature wherein said material induces calcium phosphate formation onto its surface under at least one condition of the group consisting of in vitro conditions and in vivo conditions, and wherein said elevated temperature is at least 350° C.
Claim 9
Dependent Claim
70 words
A coating composition consisting essentially of a gel-derived titania-based material that has been treated at elevated temperature wherein said material induces calcium phosphate formation onto its surface under at least one condition of the group consisting of in vitro conditions and in vivo conditions further comprising as an additive one or more of the following elements either as ions or oxides: Ca, P, Si, Na, K, B, Mg or Al.
Claim 10
Dependent Claim
70 words
A coating composition consisting essentially of a gel-derived titania-based material that has been treated at elevated temperature wherein said material induces calcium phosphate formation onto its surface under at least one condition of the group consisting of in vitro conditions and in vivo conditions further comprising as an additive one or more of the following elements either as ions or oxides: Ca, P, Si, Na, K, B, Mg or Al.
Claim 11
Dependent Claim
43 words
An implant for biomedical use comprising a substrate and a bone-bonding coating composition thereon wherein said coating composition consists essentially of a gel-derived titania-based coating material that has been treated at an elevated temperature, wherein said elevated temperature is at least 350° C.
Claim 12
Dependent Claim
43 words
An implant for biomedical use comprising a substrate and a bone-bonding coating composition thereon wherein said coating composition consists essentially of a gel-derived titania-based coating material that has been treated at an elevated temperature, wherein said elevated temperature is at least 350° C.
Claim 13
Dependent Claim
22 words
An implant according to claim 7 wherein the substrate is a tooth, hip or other joint implant or another biomedical implant substrate.
Claim 14
Dependent Claim
39 words
An implant according to claim 7 wherein the substrate is at least one substrate selected from the group consisting of polymeric substrates, metallic substrates, ceramic substrates, carbon substrates and a composite substrate comprising at least two of said substrates.
Claim 15
Dependent Claim
15 words
An implant according to claim 9 wherein the substrate is titanium or a titanium alloy.
Claim 16
Dependent Claim
34 words
An implant according to claim 7 wherein the coating composition further comprises one or more of the following elements either as ions or as oxides: Ca, P, Si, Na, K, B, Mg or Al.
Claim 17
Dependent Claim
53 words
An implant for biomedical use comprising a substrate and a bone-bonding apatite layer thereon wherein the apatite layer has been grown on a gel-derived titania coating in an in vitro solution, wherein said gel-derived titania coating was treated, prior to immersion in said solution, at an elevated temperature of at least 350° C.
Claim 18
Dependent Claim
53 words
An implant for biomedical use comprising a substrate and a bone-bonding apatite layer thereon wherein the apatite layer has been grown on a gel-derived titania coating in an in vitro solution, wherein said gel-derived titania coating was treated, prior to immersion in said solution, at an elevated temperature of at least 350° C.
Claim 19
Dependent Claim
13 words
An implant according to claim 12 wherein the solution is an SBF solution.
Claim 20
Dependent Claim
64 words
An implant for biomedical use comprising a substrate and a bone-bonding layer thereon wherein the bone-bonding layer is essentially a mixture of gel-derived titania and apatite, said apatite component having been grown on a gel-derived titania coating in an in vitro solution, wherein said gel-derived titania coating was treated, prior to immersion in said solution, at an elevated temperature of at least 350° C.
Claim 21
Dependent Claim
64 words
An implant for biomedical use comprising a substrate and a bone-bonding layer thereon wherein the bone-bonding layer is essentially a mixture of gel-derived titania and apatite, said apatite component having been grown on a gel-derived titania coating in an in vitro solution, wherein said gel-derived titania coating was treated, prior to immersion in said solution, at an elevated temperature of at least 350° C.
Claim 22
Dependent Claim
13 words
An implant according to claim 14 wherein the solution is an SBF solution.
Claim 23
Dependent Claim
46 words
A process according to claim 2 wherein one or more of the following oxides are added to the process: CaO, P 2 O 5 , Na 2 O, SiO 2 , K 2 O, Al 2 O 3 , MgO or B 2 O 3 .
References Cited (Backward Citations)
US5211661A
Cited
US4737411A
Cited
US5045318A
Cited
US5152993A
Cited
US5032552A
Cited
EP0409810A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-03-17 | 2000-09-16 | 2001-03-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-03-17 | 2004-09-16 | 2005-03-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-03-17 | 2008-09-16 | 2009-03-18 | $7700.00 | Window Closed / Lapsed |