Patent US3938507A successfully refreshed from Google Patents.
US5455231A
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Mineralized collagen
Assignee: KNC NOR Acquisition Sub Inc
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Filing: 1992-11-23
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Granted: 1995-10-03
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Expires: 2012-11-23
Abstract
Abstract Mineralized collagen is prepared by forming calcium phosphate mineral under mild agitation in situ in the presence of dispersed collagen fibrils. A stable composition is obtained with desirable physical characteristics mimicking the characteristics of bone.
Inventors
- 👤 Brent R. Constantz
- 👤 Subramanian Gunasekaran
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 07:31
CPC Classifications
C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
120 words
A calcium phosphate mineralized collagen prepared according to the method comprising: preparing a calcium phosphate mineral in the presence of a dispersion of solubilized or dispersed collagen fibrils in basic pH aqueous medium, wherein the amount of collagen present will result in a product having from about 30-80 wt. % of collagen and said pH is in the range of about 10-13, combining with agitation over at least one hour a source of soluble calcium and soluble phosphate in the correct ratio sufficient to produce said calcium phosphate mineral; and collecting the mineralized collagen; said mineralized collagen characterized by having calcium phosphate stably and uniformly distributed with the fibrils to form a substantially uniform composition of calcium phosphate and collagen.
Claim 2
Dependent Claim
120 words
A calcium phosphate mineralized collagen prepared according to the method comprising: preparing a calcium phosphate mineral in the presence of a dispersion of solubilized or dispersed collagen fibrils in basic pH aqueous medium, wherein the amount of collagen present will result in a product having from about 30-80 wt. % of collagen and said pH is in the range of about 10-13, combining with agitation over at least one hour a source of soluble calcium and soluble phosphate in the correct ratio sufficient to produce said calcium phosphate mineral; and collecting the mineralized collagen; said mineralized collagen characterized by having calcium phosphate stably and uniformly distributed with the fibrils to form a substantially uniform composition of calcium phosphate and collagen.
Claim 3
Dependent Claim
28 words
A mineralized collagen prepared according to the method of claim 1, wherein the method further comprises a non-collagenous protein moiety added to said dispersion prior to said adding.
Claim 4
Dependent Claim
129 words
A formed object composed at least in part of a calcium phosphate mineralized collagen prepared according to the method of: preparing a calcium phosphate mineral in the presence of a dispersion of solubilized or dispersed collagen fibrils in basic pH aqueous medium, wherein the amount of collagen present will result in a product having from about 30-80 wt. % of collagen and said pH is in the range of about 10-13, combining with agitation over at least one hour a source of soluble calcium and soluble phosphate in the correct ratio sufficient to produce said calcium phosphate mineral; and collecting the mineralized collagen; said mineralized collagen characterized by having calcium phosphate stably and uniformly distributed with the fibrils to form a substantially uniform composition of calcium phosphate and collagen.
Claim 5
Dependent Claim
129 words
A formed object composed at least in part of a calcium phosphate mineralized collagen prepared according to the method of: preparing a calcium phosphate mineral in the presence of a dispersion of solubilized or dispersed collagen fibrils in basic pH aqueous medium, wherein the amount of collagen present will result in a product having from about 30-80 wt. % of collagen and said pH is in the range of about 10-13, combining with agitation over at least one hour a source of soluble calcium and soluble phosphate in the correct ratio sufficient to produce said calcium phosphate mineral; and collecting the mineralized collagen; said mineralized collagen characterized by having calcium phosphate stably and uniformly distributed with the fibrils to form a substantially uniform composition of calcium phosphate and collagen.
Claim 6
Dependent Claim
140 words
A carbonate-containing calcium phosphate mineralized collagen prepared according to the method of: preparing a carbonate-containing calcium phosphate mineral in the presence of a dispersion of solubilized or dispersed collagen fibrils in basic pH aqueous medium and said pH is in the range of about 10-13, combining with agitation over at least one hour a source of soluble calcium, soluble phosphate and carbonate in the correct stoichiometry for said carbonate-containing calcium phosphate mineral, wherein said carbonate is present in said mineral in an amount up to 10% and the amount of collagen present will result in a mineralized collagen having from 30 to 80 wt. % of collagen; and collecting the mineralized collagen; said mineralized collagen characterized by having carbonate-containing calcium phosphate stably and uniformly distributed with the fibrils to form a substantially uniform composition of carbonate-containing calcium phosphate and collagen.
Claim 7
Dependent Claim
140 words
A carbonate-containing calcium phosphate mineralized collagen prepared according to the method of: preparing a carbonate-containing calcium phosphate mineral in the presence of a dispersion of solubilized or dispersed collagen fibrils in basic pH aqueous medium and said pH is in the range of about 10-13, combining with agitation over at least one hour a source of soluble calcium, soluble phosphate and carbonate in the correct stoichiometry for said carbonate-containing calcium phosphate mineral, wherein said carbonate is present in said mineral in an amount up to 10% and the amount of collagen present will result in a mineralized collagen having from 30 to 80 wt. % of collagen; and collecting the mineralized collagen; said mineralized collagen characterized by having carbonate-containing calcium phosphate stably and uniformly distributed with the fibrils to form a substantially uniform composition of carbonate-containing calcium phosphate and collagen.
References Cited (Backward Citations)
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