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US3968567A
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Endodontic composition and method
Assignee: Individual
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Filing: 1975-04-21
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Granted: 1976-07-13
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Expires: 1995-04-21
Abstract
Abstract A composition useful in forming a physiologic root end closure, a method of making the composition and a method utilizing the composition. The composition comprises a buffered solution of colloidal collagen, a calcium salt, a phosphate salt, and optionally, Lugol's solution.
Inventors
- 👤 Alan J. Nevins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:18
CPC Classifications
A; A61; A61C; A61C5/00; A61C5/50; A61K; A61K6/00; A61K6/80; A61K6/849; A61K6/876
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
61 words
A method for causing formation of a physiologic seal across the opening of a rigid, cavity-containing tubular member adjacent capsular connective tissue within a mammalian body comprising a. filling the tube with a gelable composition comprising collagen, a calcium salt, and a phosphate salt, b. allowing the composition to gel, and c. permitting the ingrowth of connective tissue into the cavity.
Claim 2
Independent Claim
61 words
A method for causing formation of a physiologic seal across the opening of a rigid, cavity-containing tubular member adjacent capsular connective tissue within a mammalian body comprising a. filling the tube with a gelable composition comprising collagen, a calcium salt, and a phosphate salt, b. allowing the composition to gel, and c. permitting the ingrowth of connective tissue into the cavity.
Claim 3
Dependent Claim
20 words
The method of claim 1, wherein the gelable composition comprises collagen, CaCl 2 , and K 2 HPO 4 .
Claim 4
Dependent Claim
22 words
The method of claim 1, wherein the gelable composition comprises collagen, CaCl 2 , K 2 HPO 4 , and Lugol's solution.
Claim 5
Dependent Claim
95 words
The method of claim 1, wherein the gelable composition has a pH in the range of about 7.4 - 7.6 and comprises the following materials in the indicated respective proportions by volume: a. 1.0 - 1.5 ml. of a collagen solution containing from 10 mg. to 60 mg. of collagen in 1 ml. of aqueous buffered solution, b. 0.05 ml. of an aqueous CaCl 2 solution having a concentration ranging from 40.5 mM to 2.0 M, and c. 0.05 ml. of aqueous K 2 HPO 4 ranging in concentration from 36.1 mM to 1.8 M.
Claim 6
Dependent Claim
25 words
The method of claim 4, wherein the composition additionally contains Lugol's solution in an amount sufficient to substantially decrease the gelling time of the composition.
Claim 7
Dependent Claim
15 words
The method of claim 5, wherein 0.05 ml. of aqueous 5% Lugol's solution is used.
Claim 8
Independent Claim
51 words
A method for closing the root canal of a tooth comprising the steps of a. excising and removing dead and devitalized tissue from the canal, b. filling the canal with a composition comprising a buffered aqueous preparation of collagen, a calcium salt and a phosphate salt, and c. sealing the canal.
Claim 9
Independent Claim
51 words
A method for closing the root canal of a tooth comprising the steps of a. excising and removing dead and devitalized tissue from the canal, b. filling the canal with a composition comprising a buffered aqueous preparation of collagen, a calcium salt and a phosphate salt, and c. sealing the canal.
Claim 10
Independent Claim
82 words
A method for inducing physiologic closure of a debrided open root canal of a tooth comprising the steps of a. opening the apical foramen thereof, b. filling the canal and adjacent opening in periapical tissue, if any, with a gelable composition comprising a buffered aqueous preparation of collagen, a calcium salt and a phosphate salt, c. sealing the canal, and d. permitting the ingrowth of connective tissue into the canal of the tooth, followed by mineralization to form a permanent physiologic closure.
Claim 11
Independent Claim
82 words
A method for inducing physiologic closure of a debrided open root canal of a tooth comprising the steps of a. opening the apical foramen thereof, b. filling the canal and adjacent opening in periapical tissue, if any, with a gelable composition comprising a buffered aqueous preparation of collagen, a calcium salt and a phosphate salt, c. sealing the canal, and d. permitting the ingrowth of connective tissue into the canal of the tooth, followed by mineralization to form a permanent physiologic closure.
Claim 12
Dependent Claim
24 words
The method of claim 8, wherein the composition is a high viscosity solution of collagen, calcium chloride and potassium phosphate, adjusted to pH 7.4.
Claim 13
Dependent Claim
94 words
The method of claim 9, wherein the composition has a pH in the range of about 7.4 - 7.6 and comprises the following materials in the indicated respective proportions by volume: a. 1.0 - 1.5 ml. of a collagen solution containing from 10 mg. to 60 mg. of collagen in 1 ml. of aqueous buffered solution, b. 0.05 ml. of an aqueous CaCl 2 solution having a concentration ranging from 40.5 mM to 2.0 M, and c. 0.05 ml. of aqueous K 2 HPO 4 ranging in concentration from 36.1 mM to 1.8 M.
Claim 14
Dependent Claim
17 words
The method of claim 10, wherein the composition additionally contains 0.05 ml. of aqueous 5% Lugol's solution.
Claim 15
Dependent Claim
69 words
A composition for use in causing formation of a physiologic closure across the opening of a rigid tubular member adjacent capsular connective tissue within a mammalian body comprising an aqueous solution of collagen, a calcium salt, and a phosphate salt, the solution being buffered to a pH within the range of 7.4 - 7.6 and the solution forming a gel upon standing within about 30 minutes at about 37°C.
Claim 16
Dependent Claim
69 words
A composition for use in causing formation of a physiologic closure across the opening of a rigid tubular member adjacent capsular connective tissue within a mammalian body comprising an aqueous solution of collagen, a calcium salt, and a phosphate salt, the solution being buffered to a pH within the range of 7.4 - 7.6 and the solution forming a gel upon standing within about 30 minutes at about 37°C.
Claim 17
Dependent Claim
20 words
The composition according to claim 12, wherein the collagen is reconstituted lyophilized, highly purified calf skin collagen, which is non-antigenic.
Claim 18
Dependent Claim
23 words
The composition of claim 12, wherein the calcium salt is calcium chloride and wherein the phosphate salt is K 2 HPO 4 .
Claim 19
Independent Claim
91 words
The method of making an endodontic composition comprising mixing at a pH range of about 7.4 - 7.6, the following materials in the indicated respective proportions by volume: a. 1.0 - 1.5 ml. of a collagen solution containing from 10 mg. to 60 mg. of collagen in 1 ml. of aqueous buffered solution, b. 0.05 ml. of an aqueous CaCl 2 solution having a concentration ranging from 40.5 mM to 2.0 M, and c. 0.05 ml. of aqueous K 2 HPO 4 ranging in concentration from 36.1 mM to 1.8 M.
Claim 20
Independent Claim
91 words
The method of making an endodontic composition comprising mixing at a pH range of about 7.4 - 7.6, the following materials in the indicated respective proportions by volume: a. 1.0 - 1.5 ml. of a collagen solution containing from 10 mg. to 60 mg. of collagen in 1 ml. of aqueous buffered solution, b. 0.05 ml. of an aqueous CaCl 2 solution having a concentration ranging from 40.5 mM to 2.0 M, and c. 0.05 ml. of aqueous K 2 HPO 4 ranging in concentration from 36.1 mM to 1.8 M.
Claim 21
Dependent Claim
21 words
The method of claim 15, wherein the materials, after mixing, are placed within an applicator syringe and permitted to gel therein.
Claim 22
Dependent Claim
78 words
A gelable endodontic composition comprising the following materials in the indicated respective proportions by volume: a. 1.0 - 1.5 ml. of a collagen solution containing from 10 mg. to 60 mg. of collagen in 1 ml. of aqueous buffered solution, b. 0.05 ml. of an aqueous CaCl 2 solution having a concentration ranging from 40.5 mM to 2.0 M, and c. 0.05 ml. of aqueous K 2 HPO 4 ranging in concentration from 36.1 mM to 1.8 M.
Claim 23
Dependent Claim
78 words
A gelable endodontic composition comprising the following materials in the indicated respective proportions by volume: a. 1.0 - 1.5 ml. of a collagen solution containing from 10 mg. to 60 mg. of collagen in 1 ml. of aqueous buffered solution, b. 0.05 ml. of an aqueous CaCl 2 solution having a concentration ranging from 40.5 mM to 2.0 M, and c. 0.05 ml. of aqueous K 2 HPO 4 ranging in concentration from 36.1 mM to 1.8 M.
Claim 24
Dependent Claim
23 words
The endodontic composition in claim 17, wherein the composition additionally comprises sufficient Lugol's solution to substantially decrease the gelling time of the composition.
Claim 25
Dependent Claim
15 words
The composition of claim 17, which additionally comprises 0.05 ml. of aqueous 5% Lugol's solution.
Claim 26
Dependent Claim
61 words
An endodontic composition comprising 1.5 ml. of collagen solution containing 10 mg. collagen per ml. of water and having a pH of 7.6, 0.05 ml. of 2.0 M aqueous CaCl 2 solution buffered to pH 7.4, 0.05 ml. of 1.8 M aqueous K 2 HPO 4 solution buffered to a pH of 7.4 and 0.05 ml. of aqueous 5% Lugol's solution.
Claim 27
Dependent Claim
61 words
An endodontic composition comprising 1.5 ml. of collagen solution containing 10 mg. collagen per ml. of water and having a pH of 7.6, 0.05 ml. of 2.0 M aqueous CaCl 2 solution buffered to pH 7.4, 0.05 ml. of 1.8 M aqueous K 2 HPO 4 solution buffered to a pH of 7.4 and 0.05 ml. of aqueous 5% Lugol's solution.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-13 | 1980-01-12 | 1980-07-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-13 | 1984-01-12 | 1984-07-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-13 | 1988-01-12 | 1988-07-13 | $7700.00 | Window Closed / Lapsed |