US6136029A
Expired / Lapsed
US
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Bone substitute materials
Assignee: Wright Medical Technology Inc
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Filing: 1997-10-01
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Granted: 2000-10-24
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Expires: 2017-10-01
Abstract
Abstract A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume and having open interconnecting interstices extending throughout said volume and opening through said surface. The article comprises a continuous strong framework structure having interstices which interconnect throughout the bulk volume and a second continuous material occupying at least a portion of the same bulk volume as the framework structure. The second material comprises an osteoinductive and/or osteoconductive composition. This composition may be present in one of several forms. One of these is as a coating on the surface of the framework structure. A second form is in the form of a composite, intimately mixed with the framework material within the framework struts. The third form is as a porous mass within the interstices of the framework structure, having pores which are interconnecting with themselves, and with the interstices of the framework structure. Desirably, the porous osteoinductive or osteoconductive composition extends throughout said bulk volume. In a preferred embodiment, the framework structure is formed of a ceramic material. In a further embodiment, the framework structure may be further structurally reinforced with a dense material component integrally affixed thereto.
Inventors
- 👤 Wesley D. Johnson
- 👤 James R. Johnson
- 👤 Jeffrey G. Marx
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:14
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2/30; A61F2/30767; A61L; A61L27/00; A61L27/40; A61L27/42; A61L27/425; A61L27/427; A61L27/50; A61L27/56; A61F2/32; A61F2/36; A61F2/3662; A61F2/367; A61F2/38; A61F2/389; A61F2002/2817; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30092; A61F2/30771; A61F2002/30878; A61F2002/30884; A61F2/3094; A61F2002/30968; A61F2210/00; A61F2210/0014; A61F2310/00; A61F2310/00005; A61F2310/00011; A61F2310/00017; A61F2310/00023; A61F2310/00029; A61F2310/00035; A61F2310/00131; A61F2310/00179; A61F2310/00185; A61F2310/00203; A61F2310/00239; A61F2310/00293; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
78 words
A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume, the article comprising a continuous strong supportive sintered, load-bearing framework having struts defining a plurality of interconnecting interstices throughout the bulk volume, and a porous osteoconductive composition carried by said supporting framework, said article having interconnecting openings extending throughout said volume and opening through said surface with said osteoconductive composition being exposed to said interconnected openings.
Claim 2
Dependent Claim
78 words
A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume, the article comprising a continuous strong supportive sintered, load-bearing framework having struts defining a plurality of interconnecting interstices throughout the bulk volume, and a porous osteoconductive composition carried by said supporting framework, said article having interconnecting openings extending throughout said volume and opening through said surface with said osteoconductive composition being exposed to said interconnected openings.
Claim 3
Dependent Claim
14 words
The article of claim 1 wherein said osteoconductive composition extends throughout said bulk volume.
Claim 4
Dependent Claim
41 words
The article of claim 1 wherein interconnecting interstices of said supportive framework terminate in said outer surface and wherein the osteoconductive composition extends from said outer surface inwardly of said shape but not throughout the entire bulk volume of the shape.
Claim 5
Dependent Claim
18 words
The article of claim 1 wherein said osteoconductive composition is carried as a continuous coating on said struts.
Claim 6
Dependent Claim
24 words
The article of claim 1 wherein said osteoconductive composition includes pores that communicate with but are not coextensive with interstices of the supportive framework.
Claim 7
Dependent Claim
25 words
The article of claim 1 wherein said supportive framework has a void volume that is at least 50% of the bulk volume of the article.
Claim 8
Dependent Claim
17 words
The article of claim 1 wherein said supportive framework includes said osteoconductive composition incorporated in said struts.
Claim 9
Dependent Claim
14 words
The article of claim 1 including in said openings a calcium phosphate bone cement.
Claim 10
Dependent Claim
32 words
The article of any one of claims 1 through 6 including a comparatively dense structural element attached to a surface of said bulk volume and having a porosity not greater than 10%.
Claim 11
Dependent Claim
25 words
The article of claim 9 wherein said structural element comprises a rod useful as a stem receivable in the intramedullary canal of a long bone.
Claim 12
Dependent Claim
21 words
The article of claim 9 wherein said structural element comprises a plate useful as the tibial tray of a knee prosthesis.
Claim 13
Dependent Claim
16 words
The article of any one of claims 1 through 8 wherein said supportive framework is ceramic.
Claim 14
Dependent Claim
23 words
The article of any one of claims 1 through 8 including an osteoinductive material carried by said structure and exposed to said interstices.
Claim 15
Dependent Claim
82 words
A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume, the article comprising a continuous strong supportive sintered, load-bearing framework comprising zirconia, the framework having struts defining a plurality of interconnecting interstices throughout the bulk volume, and a porous osteoconductive composition carried by said supporting framework, said article having interconnecting openings extending throughout said volume and opening through said surface with said osteoconductive composition being exposed to said interconnecting openings.
Claim 16
Dependent Claim
82 words
A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume, the article comprising a continuous strong supportive sintered, load-bearing framework comprising zirconia, the framework having struts defining a plurality of interconnecting interstices throughout the bulk volume, and a porous osteoconductive composition carried by said supporting framework, said article having interconnecting openings extending throughout said volume and opening through said surface with said osteoconductive composition being exposed to said interconnecting openings.
Claim 17
Dependent Claim
27 words
The article of claim 14 wherein said supporting framework includes a ceramic osteoconductive composition carried at discrete locations along said struts and exposed to said interconnecting openings.
Claim 18
Dependent Claim
32 words
The article of claim 14 wherein said osteoconductive composition is carried as a substantially continuous coating formed on said struts, and wherein said supporting framework and said osteoconductive composition have 3--3 connectivity.
Claim 19
Dependent Claim
18 words
The article of claim 15 or claim 16 wherein said ceramic osteoconductive composition comprises a calcium phosphate compound.
Claim 20
Dependent Claim
86 words
A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume and having interconnecting openings extending throughout said volume and opening through said surface, the article comprising a continuous strong supportive sintered, load-bearing framework having struts defining a plurality of interconnecting interstices throughout the bulk volume, a first porous osteoconductive composition carried by said supporting framework, and a second porous osteoconductive composition carried by said first porous osteoconductive composition and exposed to said interconnected openings.
Claim 21
Dependent Claim
86 words
A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume and having interconnecting openings extending throughout said volume and opening through said surface, the article comprising a continuous strong supportive sintered, load-bearing framework having struts defining a plurality of interconnecting interstices throughout the bulk volume, a first porous osteoconductive composition carried by said supporting framework, and a second porous osteoconductive composition carried by said first porous osteoconductive composition and exposed to said interconnected openings.
Claim 22
Dependent Claim
36 words
The article of claim 18 wherein said first and second porous osteoconductive compositions each include an osteoconductive material with the concentration of osteoconductive material in the second composition being greater than that of the first composition.
Claim 23
Dependent Claim
105 words
A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume and having interconnecting openings extending throughout said volume and opening through said surface, the article comprising a continuous strong supportive sintered, load-bearing framework comprising zirconia, the struts defining a plurality of interconnecting interstices throughout the bulk volume, a first porous osteoconductive composition including hydroxy appetite carried by the supportive framework, and a second porous osteoconductive composition carried by said first composition and exposed to said interconnecting openings, said second composition containing hydroxy appetite in a concentration greater than that of the first composition.
Claim 24
Dependent Claim
105 words
A strong, porous article useful as a bone substitute material and having an outer surface defining a shape having a bulk volume and having interconnecting openings extending throughout said volume and opening through said surface, the article comprising a continuous strong supportive sintered, load-bearing framework comprising zirconia, the struts defining a plurality of interconnecting interstices throughout the bulk volume, a first porous osteoconductive composition including hydroxy appetite carried by the supportive framework, and a second porous osteoconductive composition carried by said first composition and exposed to said interconnecting openings, said second composition containing hydroxy appetite in a concentration greater than that of the first composition.
Claim 25
Dependent Claim
15 words
The composition of claim 20 wherein said first and second porous osteoconductive compositions include zirconia.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-10-24 | 2004-04-24 | 2004-10-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-10-24 | 2008-04-24 | 2008-10-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-10-24 | 2012-04-24 | 2012-10-24 | $7700.00 | Window Closed / Lapsed |