US4976736A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Coated biomaterials and methods for making same
Assignee: Biomet Manufacturing LLC
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Filing: 1989-04-28
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Granted: 1990-12-11
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Expires: 2009-04-28
Abstract
Abstract Biomaterials useful for onthopedicanel dental applications is disclosed. These materials have a base portion of calcium carbonate and a surface layer of a synthetic phosphate such as hydroxyapatite. The base portion may be a calcium carbonate structure having three-dimensional interconnected porosity such as may be found in porous skeletal carbonate of marine life, e.g. coral porites skeletal aragonite, or it may be porous or non-porous granules of calcium carbonate. A method for making the biomaterials is also disclosed. The synthetic phosphate surface is made using a hydroconversion reaction with a soluble or solubilized phosphate such as ammonium dibasic phosphate ((NH4) 2 HPO4).
Inventors
- 👤 Eugene W. White
- 👤 Edwin C. Shors
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:30
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/28; A61L27/30; A61L27/32; A61L27/34; A61L27/50; A61L27/54; A61L27/56; A61F; A61F2310/00; A61F2310/00389; A61F2310/00592; A61F2310/00796; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/412; A61L2300/414
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
19 words
A biomaterial comprising a base portion consisting essentially of calcium carbonate and having a surface layer of synthetic phosphate.
Claim 2
Dependent Claim
19 words
A biomaterial comprising a base portion consisting essentially of calcium carbonate and having a surface layer of synthetic phosphate.
Claim 3
Dependent Claim
26 words
A biomaterial as recited in claim 1 having a three dimensional porous microstructure corresponding to the microstructure of porous carbonate echinoderm or schleractinian coral skeletal material.
Claim 4
Dependent Claim
19 words
A biomaterial as recited in claim 1 wherein said surface layer has a thickness less than about 25 microns.
Claim 5
Dependent Claim
18 words
A biomaterial as recited in claim 2 wherein said base portion is porous calcium carbonate derived from coral.
Claim 6
Dependent Claim
25 words
A biomaterial as recited in claim 4 wherein said surface layer is made by converting the surface of said calcium carbonate base portion to hydroxyapatite.
Claim 7
Dependent Claim
22 words
A biomaterial as recited in claim 2 wherein said base portion is Porites coral and said surface layer consists essentially of hydroxyapatite.
Claim 8
Dependent Claim
24 words
A biomaterial as recited in claim 2 wherein said base portion is Goniopora or Alveolopora coral and said surface layer consists essentially of hydroxyapatite.
Claim 9
Dependent Claim
15 words
A biomaterial as recited in claim 1 wherein said base portion is solid calcium carbonate.
Claim 10
Dependent Claim
16 words
A biomaterial as recited in claim 6 having an average pore diameter of about 200 microns.
Claim 11
Dependent Claim
15 words
A biomaterial as recited in claim 7 having an averagepore diameter of about 500 microns.
Claim 12
Dependent Claim
17 words
A biomaterial as recited in claim 2 having pore sizes in the range of about 5-1000 microns.
Claim 13
Dependent Claim
29 words
A biomaterial as recited in claim 2 wherein said base portion is Porites or Goniopora coral and said surface layer is made by converting calcium carbonate to calcium phosphate.
Claim 14
Dependent Claim
25 words
A biomaterial in accordance with claim 2 having substantially uniform pore connections or openings in the range from about 5 microns to about 1000 microns.
Claim 15
Dependent Claim
15 words
A biomaterial in accordance with claim 1 wherein the synthetic phosphate is hydroxyapatite or whitlockite.
Claim 16
Dependent Claim
23 words
A biomaterial in accordance with claim 2 wherein said base portion is coral skeletal aragonite and said surface layer consists essentially of hydroxyapatite.
Claim 17
Dependent Claim
16 words
A biomaterial in accordance with claim 15 wherein said coral skeletal aragonite is Porites skeletal aragonite.
Claim 18
Dependent Claim
16 words
A biomaterial in accordance with claim 1 wherein said base portion is a calcium carbonate granule.
Claim 19
Dependent Claim
13 words
A biomaterial in accordance with claim 17 wherein said base portion is solid.
Claim 20
Dependent Claim
19 words
A biomaterial in accordance with claim 17 wherein said calcium carbonate granule is porous and is derived from coral.
Claim 21
Dependent Claim
22 words
A biomaterial in accordance with claim 17 wherein the diameter of said granule ranges from about 425 microns to about 5 millimeters.
Claim 22
Dependent Claim
23 words
A biomaterial in accordance with claim 20 wherein the average diameter of said granule ranges from about 425 microns to about 600 microns.
Claim 23
Dependent Claim
26 words
A biomaterial as recited in claim 2 wherein said base portion is derived from porous echinoderm skeletal material and said surface layer consists essentially of whitlockite.
Claim 24
Dependent Claim
121 words
A synthetic biomaterial characterized by a substantially uniform pore volume in the range from about 10% to about 90% and having a microstructure characterized by a pronounced three dimensional fenestrate structure corresponding to the microstructure of the porous carbonate echinoderm or schleractinian coral skeletal material of marine life and providing a periodic minimal surface, said periodic minimal surface dividing the volume of said material into two interpenetrating regions, each of which is a single, multiply connected domain, said material having a substantially uniform pore size diameter and substantially uniform pore connection or openings in the range from about 5 microns to about 1000 microns, said synthetic material comprising a base portion of calcium carbonate and a surface layer of calcium phosphate.
Claim 25
Dependent Claim
121 words
A synthetic biomaterial characterized by a substantially uniform pore volume in the range from about 10% to about 90% and having a microstructure characterized by a pronounced three dimensional fenestrate structure corresponding to the microstructure of the porous carbonate echinoderm or schleractinian coral skeletal material of marine life and providing a periodic minimal surface, said periodic minimal surface dividing the volume of said material into two interpenetrating regions, each of which is a single, multiply connected domain, said material having a substantially uniform pore size diameter and substantially uniform pore connection or openings in the range from about 5 microns to about 1000 microns, said synthetic material comprising a base portion of calcium carbonate and a surface layer of calcium phosphate.
Claim 26
Dependent Claim
24 words
A biomaterial in accordance with claim 23, wherein said biomaterial has the microstructure of echinoderm skeletal calcite and surface layer consists essentially of whitlockite.
Claim 27
Dependent Claim
22 words
A biomaterial in accordance with claim 23 having the microstructure of coral skeletal aragonite and said surface layer consists essentially of hydroxyapatite.
Claim 28
Dependent Claim
16 words
A biomaterial in accordance with claim 25 wherein said coral skeletal aragonite is Porites skeletal aragonite.
Claim 29
Dependent Claim
25 words
A biomaterial in accordance with claim 23 having the microstructure of Alveolopora or Goniopora skeletal aragonite and wherein said surface layer consists essentially of hydroxyapatite.
Claim 30
Dependent Claim
50 words
A biomaterial in accordance with claim 23 wherein the microstructure has the ratio of pore volume to the volume of solid of approximately 1 and has a cross-sectional diameter of both the pore and solid phase of about the same dimension ranging from about 5 microns to about 1000 microns.
Claim 31
Dependent Claim
20 words
A biomaterial in accordance with claim 23 having pore sizes in the range from about 40 to about 250 microns.
Claim 32
Dependent Claim
25 words
A biomaterial in accordance with claim 23 wherein said biomaterial is shaped or formed into a shape commensurate with a bone repair or replacement function.
Claim 33
Dependent Claim
19 words
A biomaterial in accordance with claim 30 wherein said phosphate surfaced calcium carbonate biomaterial is hydroxyapatite surfaced calcium carbonate.
Claim 34
Dependent Claim
16 words
A biomaterial in accordance with claim 23 having an average pore size of about 500 microns.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-12-10 | 1994-06-11 | 1994-12-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-12-10 | 1998-06-11 | 1998-12-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-12-10 | 2002-06-11 | 2002-12-11 | $7700.00 | Window Closed / Lapsed |