US5972368A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Bone graft composites and spacers
Assignee: Warsaw Orthopedic Inc
•
Filing: 1997-06-11
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Granted: 1999-10-26
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Expires: 2017-06-11
Abstract
Abstract A bone graft substitute including a composition of natural selectively deactivated bone material which has been processed to remove associated non-collagenous bone proteins, said bone material containing native collagen materials and naturally associated bone minerals and substantially free from native non-collagenous protein, and a therapeutically effective amount to stimulate bone growth of a bone growth factor in a pharmaceutically acceptable carrier in synergistic combination with said bone material. Spacers composed of the bone graft substitute composition methods for using the spacers are also provided.
Inventors
- 👤 William F. McKay
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:39
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3695; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L2430/00; A61L2430/02; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/84; Y10S606/00; Y10S606/907; Y10S606/908; Y10S606/909; Y10S606/912
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
64 words
A bone graft substitute composition, comprising: natural selectively deactivated bone material which has been processed to remove associated non-collagenous bone proteins, said bone material containing native collagen materials and naturally associated bone minerals and substantially free from native non-collagenous protein; and a therapeutically effective amount to stimulate bone growth of a bone growth factor in a pharmaceutically acceptable carrier dispersed within said bone material.
Claim 2
Dependent Claim
64 words
A bone graft substitute composition, comprising: natural selectively deactivated bone material which has been processed to remove associated non-collagenous bone proteins, said bone material containing native collagen materials and naturally associated bone minerals and substantially free from native non-collagenous protein; and a therapeutically effective amount to stimulate bone growth of a bone growth factor in a pharmaceutically acceptable carrier dispersed within said bone material.
Claim 3
Dependent Claim
21 words
The bone graft substitute of claim 1 wherein said deactivated bone is processed at temperatures no higher than about 250° C.
Claim 4
Dependent Claim
17 words
The bone graft substitute of claim 1 wherein said deactivated bone is substantially free from free collagen.
Claim 5
Dependent Claim
15 words
The bone graft substitute of claim 1 wherein said bone growth factor is recombinant BMP-2.
Claim 6
Dependent Claim
15 words
The bone graft substitute of claim 2 wherein said bone growth factor is recombinant BMP-2.
Claim 7
Dependent Claim
91 words
A spacer for maintaining a space between a pair of adjacent vertebrae in a spine, comprising: a body sized and shaped to fit within the space, said body composed of a natural selectively deactivated bone material which has been processed to remove associated non-collagenous bone proteins, said bone material containing native collagen materials and naturally associated bone minerals and substantially free from native non-collagenous protein; and a therapeutically effective amount to stimulate bone growth of a bone growth factor in a pharmaceutically acceptable carrier in synergistic combination with said bone material.
Claim 8
Dependent Claim
91 words
A spacer for maintaining a space between a pair of adjacent vertebrae in a spine, comprising: a body sized and shaped to fit within the space, said body composed of a natural selectively deactivated bone material which has been processed to remove associated non-collagenous bone proteins, said bone material containing native collagen materials and naturally associated bone minerals and substantially free from native non-collagenous protein; and a therapeutically effective amount to stimulate bone growth of a bone growth factor in a pharmaceutically acceptable carrier in synergistic combination with said bone material.
Claim 9
Dependent Claim
47 words
The spacer of claim 6 wherein said body defines a superior wall for contacting one of the vertebrae, an inferior wall for contacting the other vertebra and a lateral wall adjacent and between said superior wall and said inferior wall, said lateral wall defining a thru hole.
Claim 10
Dependent Claim
14 words
The spacer of claim 6 wherein said body is derived from a femoral ring.
Claim 11
Dependent Claim
14 words
The spacer of claim 6 wherein said body is derived from a bone dowel.
Claim 12
Dependent Claim
19 words
The spacer of claim 6 wherein said walls define a chamber and said carrier is packed within said chamber.
Claim 13
Dependent Claim
13 words
The spacer of claim 6 wherein said carrier is dispersed within said material.
Claim 14
Dependent Claim
19 words
The spacer of claim 6 wherein said body is fully resorbable after implantation no later than about five months.
Claim 15
Dependent Claim
20 words
The spacer of claim 6 wherein said body has approximately the radiopacity, after implantation, of the bones of the vertebrate.
Claim 16
Dependent Claim
12 words
The spacer of claim 6 wherein said bone graft is bovine bone.
Claim 17
Dependent Claim
54 words
A composition, comprising: processed bone material composed of bone minerals having a natural crystalline structure of bone and native collagen materials, said processed bone material substantially free of non-collagenous bone proteins; and a therapeutically effective amount to stimulate bone growth of a bone growth factor in a pharmaceutically acceptable carrier dispersed within said material.
Claim 18
Dependent Claim
54 words
A composition, comprising: processed bone material composed of bone minerals having a natural crystalline structure of bone and native collagen materials, said processed bone material substantially free of non-collagenous bone proteins; and a therapeutically effective amount to stimulate bone growth of a bone growth factor in a pharmaceutically acceptable carrier dispersed within said material.
Claim 19
Dependent Claim
26 words
An elastic body consisting essentially of selectively deactivated bone in synergistic combination with a therapeutically effective amount to stimulate bone growth of a bone growth factor.
Claim 20
Dependent Claim
26 words
An elastic body consisting essentially of selectively deactivated bone in synergistic combination with a therapeutically effective amount to stimulate bone growth of a bone growth factor.
Claim 21
Dependent Claim
12 words
The elastic body of claim 16 wherein said bone includes native collagen.
Claim 22
Dependent Claim
89 words
A surgical procedure for stabilizing a spine, comprising the steps of: exposing a portion of each of adjacent vertebrae requiring stabilization; and placing a processed bone material within an area between the portions of the adjacent vertebrae, the material composed of bone minerals having a natural crystalline structure of bone and native collagen materials, the processed bone material substantially free of non-collagenous bone proteins, and a therapeutically effective amount to stimulate bone growth of a bone growth factor in a pharmaceutically acceptable carrier in synergistic combination with the material.
Claim 23
Dependent Claim
89 words
A surgical procedure for stabilizing a spine, comprising the steps of: exposing a portion of each of adjacent vertebrae requiring stabilization; and placing a processed bone material within an area between the portions of the adjacent vertebrae, the material composed of bone minerals having a natural crystalline structure of bone and native collagen materials, the processed bone material substantially free of non-collagenous bone proteins, and a therapeutically effective amount to stimulate bone growth of a bone growth factor in a pharmaceutically acceptable carrier in synergistic combination with the material.
Claim 24
Dependent Claim
26 words
The procedure of claim 18 wherein the bone material is formed into an elastic body defining a chamber and the carrier is packed into the chamber.
Claim 25
Dependent Claim
13 words
The procedure of claim 18 wherein the carrier is dispersed within the material.
Claim 26
Dependent Claim
19 words
The procedure of claim 18 wherein the portions of the spine are at the posterolateral aspect of the spine.
Claim 27
Dependent Claim
13 words
The procedure of claim 21 wherein said processed bone material includes bone chips.
Claim 28
Dependent Claim
13 words
The composition of claim 15 wherein said processed bone material is bone chips.
Claim 29
Dependent Claim
16 words
The composition of claim 23 further comprising a binding matrix, said chips disposed within said matrix.
Claim 30
Dependent Claim
10 words
The composition of claim 24 wherein said matrix includes collagen.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-10-25 | 2003-04-26 | 2003-10-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-10-25 | 2007-04-26 | 2007-10-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-10-25 | 2011-04-26 | 2011-10-26 | $7700.00 | Window Closed / Lapsed |