US4882149A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical depot preparation
Assignee: OSTEOMEDICAL Ltd UK
•
Filing: 1988-09-21
•
Granted: 1989-11-21
•
Expires: 2008-09-21
Abstract
Abstract Pharmaceutical depot preparation for implantation into base tissue comprising natural bone mineral from which the naturally associated fat and bone-proteins have been removed whereby said bone is sterile and non-allergenic, said bone mineral having absorbed thereon and/or adsorbed therein one or more physiologically active substances. The physiologically active substance is advantageously an antibiotic or taurolidine or tauraltam or a protein or polypeptide assisting bone regeneration.
Inventors
- 👤 Myron Spector
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:35
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61F; A61F2/00; A61F2/02; A61F2/28; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2009; A61L27/14; A61L27/22; A61L27/227; A61L27/3641; A61L27/3645; A61L27/365; A61L27/50; A61L27/54; A61F2/30; A61F2002/30001; A61F2002/30667; A61F2002/30677; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/20; A61L2300/204; A61L2300/252; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/60; A61L2300/62; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/919
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
45 words
Pharmaceutical depot preparations for implantation into bone tissue comprising natural bone mineral from which the naturally associated fat and bone-proteins have been removed whereby said bone is sterile and non-allergenic, said bone mineral having adsorbed thereon and/or absorbed therein one or more physiologically active substances.
Claim 2
Dependent Claim
45 words
Pharmaceutical depot preparations for implantation into bone tissue comprising natural bone mineral from which the naturally associated fat and bone-proteins have been removed whereby said bone is sterile and non-allergenic, said bone mineral having adsorbed thereon and/or absorbed therein one or more physiologically active substances.
Claim 3
Dependent Claim
18 words
Preparations as claimed in claim 1 in the form of particles of average diameter 0.1 to 3 mm.
Claim 4
Dependent Claim
31 words
Preparations as claimed in claim 1 or claim 2 in which the physiologically active substance is an antibiotic or a condensation product of formaldehyde with taurinamide or an N-C 1-4 alkyl-taurinamide.
Claim 5
Dependent Claim
16 words
Preparations as claimed in claim 3 in which the physiologically active substance is taurolidine or taurultam.
Claim 6
Dependent Claim
24 words
Preparations as claimed in claim 1 or 2 in which the physiologically active substance is a protein or polypeptide capable of assisting bone regeneration.
Claim 7
Independent Claim
46 words
A method of preparing a pharmaceutical depot preparation for implantation into bone tissue wherein natural bone is subjected to extraction of fat and bone protein therefrom whereby said bone is sterile and non-allergenic whereafter one or more physiologically active substances is adsorbed thereon or absorbed therein.
Claim 8
Independent Claim
46 words
A method of preparing a pharmaceutical depot preparation for implantation into bone tissue wherein natural bone is subjected to extraction of fat and bone protein therefrom whereby said bone is sterile and non-allergenic whereafter one or more physiologically active substances is adsorbed thereon or absorbed therein.
Claim 9
Dependent Claim
24 words
A method of filling congenital, surgical or traumatic defects in bone whereby said defect is filled with a preparation as claimed in claim 1.
Claim 10
Dependent Claim
45 words
A method as claimed in claim 1 for filling osteitis cavities, defects arising from surgical removal of cysts and tumours, maxillo-facial or cranio-facial surgery or dental or oral surgery, for formation of cementless prostheses in joint replacement or for grouting bone fragments in complex features.
Claim 11
Dependent Claim
23 words
A bone material from which fat and bone-protein have been removed for use in the formation of preparations as claimed in claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-20 | 1993-05-22 | 1993-11-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-20 | 1997-05-22 | 1997-11-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-20 | 2001-05-22 | 2001-11-21 | $7700.00 | Window Closed / Lapsed |