US5899939A
Expired / Lapsed
US
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Bone-derived implant for load-supporting applications
Assignee: Warsaw Orthopedic Inc
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Filing: 1998-01-21
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Granted: 1999-05-04
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Expires: 2018-01-21
Abstract
Abstract A bone-derived implant is provided which is made up of one or more layers of fully mineralized or partially demineralized cortical bone and, optionally, one or more layers of some other material. The layers constituting the implant are assembled into a unitary structure to provide an implant exhibiting good overall load-supporting properties.
Inventors
- 👤 Todd M. Boyce
- 👤 Albert Manrique
- 👤 Nelson L. Scarborough
- 👤 James L. Russell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:59
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3683; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61F2/30; A61F2/3094; A61F2/44; A61F2/442; A61F2/4455; A61F2002/2817; A61F2002/2835; A61F2002/2839; A61F2/2875; A61F2002/2882; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30059; A61F2002/30108; A61F2002/3011; A61F2002/30112; A61F2002/30113; A61F2002/30125; A61F2002/30138; A61F2002/30153; A61F2002/30154; A61F2002/30199; A61F2002/30224; A61F2002/30261; A61F2002/30316; A61F2002/30329; A61F2002/30448; A61F2002/30535; A61F2002/30599; A61F2/30767; A61F2/30771; A61F2002/30772; A61F2002/30784; A61F2002/30785; A61F2002/30789; A61F2002/30971; A61F2002/448; A61F2220/00; A61F2220/0025; A61F2220/005; A61F2230/00; A61F2230/0002; A61F2230/0004; A61F2230/0006; A61F2230/0008; A61F2230/0017; A61F2230/0019; A61F2230/0021; A61F2230/0063; A61F2230/0069; A61F2230/0082; A61F2250/00; A61F2250/0058; A61F2250/006; A61F2250/0063; A61F2310/00; A61F2310/00005; A61F2310/00179; A61F2310/00293; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
40 words
A bone-derived implant which comprises a plurality of superimposed layers assembled with an adhesive into a unitary structure, at least one layer in the structure being a compression strength-imparting layer fabricated from nondemineralized cortical bone or partially demineralized cortical bone.
Claim 2
Dependent Claim
40 words
A bone-derived implant which comprises a plurality of superimposed layers assembled with an adhesive into a unitary structure, at least one layer in the structure being a compression strength-imparting layer fabricated from nondemineralized cortical bone or partially demineralized cortical bone.
Claim 3
Dependent Claim
30 words
The bone-derived implant of claim 1 wherein the partially demineralized bone exhibits not less than about 40 percent of the compression strength of a comparable layer of fully mineralized bone.
Claim 4
Dependent Claim
30 words
The bone-derived implant of claim 1 wherein the partially demineralized bone exhibits not less than about 50 percent of the compression strength of a comparable layer of fully mineralized bone.
Claim 5
Dependent Claim
30 words
The bone-derived implant of claim 1 wherein the partially demineralized bone exhibits not less than about 60 percent of the compression strength of a comparable layer of fully mineralized bone.
Claim 6
Dependent Claim
13 words
The bone-derived implant of claim 1 possessing at least two compression strength-imparting layers.
Claim 7
Dependent Claim
16 words
The bone-derived implant of claim 1 possessing a total thickness of at least about 5 mm.
Claim 8
Dependent Claim
16 words
The bone-derived implant of claim 1 possessing a total thickness of at least about 10 mm.
Claim 9
Dependent Claim
41 words
The bone-derived implant of claim 1 possessing a cross section for at least a portion of its length which is, or approximates, a circle, oval or polygon, the implant optionally possessing a cavity for at least a portion of its length.
Claim 10
Dependent Claim
23 words
The bone-derived implant of claim 8 wherein pores, apertures, perforations or channels provide communication between the cavity and the surface of the bone.
Claim 11
Dependent Claim
35 words
The bone-derived implant of claim 1 wherein at least one compression strength-imparting layer is provided as a multi-sectional bone section wherein subsections of bone constituting the section are joined to each other in edge-to-edge fashion.
Claim 12
Dependent Claim
35 words
The bone-derived implant of claim 1 wherein at least one compression strength-imparting later is provided as a multi-sectional bone section wherein subsections of bone constituting the section are joined to each other in edge-to-edge fashion.
Claim 13
Dependent Claim
21 words
The bone-derived implant of claim 1 possessing upper and lower major exposed surfaces, said surfaces being those of compression strength-imparting layers.
Claim 14
Dependent Claim
35 words
The bone-derived implant of claim 1 possessing at least one layer fabricated from a material selected from the group consisting of fully demineralized bone, graphite, pyrolytic carbon, hydroxyapatite, tricalcium phosphate, bioabsorbable material and nonbioabsorbable material.
Claim 15
Dependent Claim
29 words
The bone-derived implant of claim 1 wherein each strength-imparting layer possesses the same or different average thickness in the range of from about 0.5 mm to about 20 mm.
Claim 16
Dependent Claim
28 words
The bone-derived implant of claim 1 wherein each layer possesses the same or different average thickness in the range of from about 1.5 mm to about 15 mm.
Claim 17
Dependent Claim
21 words
The bone-derived implant of claim 5 wherein the at least two consecutive compression strength-imparting layers each possess a compression strength axis.
Claim 18
Dependent Claim
26 words
The bone-derived implant of claim 16 wherein the compression strength axis of the at least two consecutive compression strength-imparting layers are offset relative to each other.
Claim 19
Dependent Claim
50 words
The bone-derived implant of claim 17 wherein the at least two consecutive compression strength-imparting layers are each made up of spaced-apart sections with the compression strength axis of each of the layers being offset relative to each other in an arrangement defining an array of channels in all three dimensions.
Claim 20
Dependent Claim
18 words
The bone-derived implant of claim 1 having a compression strength of from about 25 to about 250 MPa.
Claim 21
Dependent Claim
18 words
The bone-derived implant of claim 1 having a compression strength of from about 100 to about 200 MPa.
Claim 22
Dependent Claim
13 words
The bone-derived implant of claim 1 possessing from 2 to about 200 layers.
Claim 23
Dependent Claim
15 words
The bone-derived implant of claim 13 possessing means for facilitating diffusion of bone healing material.
Claim 24
Dependent Claim
24 words
The bone-derived implant of claim 22 wherein the means for facilitating diffusion of bone healing material constitutes channels defined within one or more layers.
Claim 25
Dependent Claim
24 words
The bone-derived implant of claim 1 fabricated in whole or in part from cortical bone selected from the group consisting of allogenic and xenogenic.
Claim 26
Dependent Claim
11 words
The bone-derived implant of claim 1 containing at least one cavity.
Claim 27
Dependent Claim
29 words
The bone-derived implant of claim 25 wherein the cavity contains a material selected from the group consisting of collagen, antiviral agent, antimicrobial, antibiotic, angiogenic, antigenic agent and cytoskeletal agent.
Claim 28
Dependent Claim
38 words
The bone-derived implant of claim 1 wherein the adhesive is selected from the group consisting of cyanoacrylate, epoxy-based compound, dental resin sealant, dental resin cement, polymethylmethacrylate, gelatin-resorcinol-formaldehyde-glue, collagen-based glue, zinc phosphate, magnesium phosphate, zinc carboxylate and fibrin glue.
Claim 29
Independent Claim
61 words
A method for treating a bone defect site which comprises: providing a bone-derived implant which comprises a plurality of superimposed layers assembled with an adhesive into a unitary structure, at least one layer in the structure being a compression strength-imparting layer fabricated from nondemineralized cortical bone or partially demineralized cortical bone, and implanting the bone-derived implant at the bone defect site.
Claim 30
Independent Claim
61 words
A method for treating a bone defect site which comprises: providing a bone-derived implant which comprises a plurality of superimposed layers assembled with an adhesive into a unitary structure, at least one layer in the structure being a compression strength-imparting layer fabricated from nondemineralized cortical bone or partially demineralized cortical bone, and implanting the bone-derived implant at the bone defect site.
Claim 31
Dependent Claim
29 words
The method of claim 28 wherein the partially demineralized bone exhibits not less than about 40 percent of the compression strength of a comparable layer of fully mineralized bone.
Claim 32
Dependent Claim
29 words
The method of claim 29 wherein the partially demineralized bone exhibits not less than about 60 percent of the compression strength of a comparable layer of fully mineralized bone.
Claim 33
Dependent Claim
24 words
The method of claim 28 wherein the step of providing the bone-derived implant further comprises machining the bone-derived implant into a suitable bone configuration.
Claim 34
Dependent Claim
56 words
The method of claim 31 wherein the bone configuration is selected from the group consisting of ethmoid, frontal, nasal, occipital, parietal, temporal, mandible, maxilla, zygomatic, cervical vertebra, thoracic vertebra, lumbar vertebra, sacrum, rib, sternum, clavicle, scapula, humerus, radius, ulna, carpal bones, metacarpal bones, phalanges, ilium, ischium, pubis, femur, tibia, fibula, patella, calcaneus, tarsal and metatarsal bones.
Claim 35
Dependent Claim
15 words
The bone-derived implant of claim 1 wherein the superimposed layers are assembled with mechanical fasteners.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-05-03 | 2002-11-02 | 2003-05-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-05-03 | 2006-11-02 | 2007-05-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-05-03 | 2010-11-02 | 2011-05-04 | $7700.00 | Window Closed / Lapsed |