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US4637931A
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Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
Assignee: United States Department of the Army
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Filing: 1984-10-09
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Granted: 1987-01-20
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Expires: 2004-10-09
Abstract
Abstract A novel bone repair material consisting essential of decalcified freeze-dd bone and biodegradable, biocompatible copolymer has been developed for improving and accelerating the healing of osseous tissue. The bone repair material was prepared by combining decalcified bone with a copolymer consisting essentially of a 50:50 poly(L)(-)lactide co-glycolide.
Inventors
- 👤 John P. Schmitz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:50
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3641; A61L27/3645; A61L27/365; A61L27/14; A61L27/18; A61L27/3604; A61L27/3608; A61L27/3683
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
43 words
A method for promoting the healing of osseous tissue which comprises implanting at the site of the broken osseous tissue a therapeutically-effective amount of a composition comprising decalcified freeze-dried bone incorporated into a biodegradable polymeric matrix comprised of a copolymer of poly(L)(-)lactide co-glycolide.
Claim 2
Independent Claim
43 words
A method for promoting the healing of osseous tissue which comprises implanting at the site of the broken osseous tissue a therapeutically-effective amount of a composition comprising decalcified freeze-dried bone incorporated into a biodegradable polymeric matrix comprised of a copolymer of poly(L)(-)lactide co-glycolide.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein said bone is cortical bone which was decalcified in 0.6 normal hydrochloric acid.
Claim 4
Dependent Claim
25 words
The method of claim 1 wherein the amount of the decalcified freeze-dried bone is about 40 to 60 percent by weight of said polymeric matrix.
Claim 5
Dependent Claim
25 words
The method of claim 3 wherein the amount of the decalcified freeze-dried bone is about 45 to 55 percent by weight of said polymeric matrix.
Claim 6
Dependent Claim
20 words
The method of claim 4 wherein the amount of decalcified freeze-dried bone is about 50 percent of said polymeric matrix.
Claim 7
Dependent Claim
12 words
The method of claim 1 wherein the copolymer is 50:50 poly(L)(-)lactide co-glycolide.
Claim 8
Dependent Claim
19 words
The method of claim 6 wherein the amount of decalcified freeze-dried bone is about 50 percent of said copolymer.
Claim 9
Dependent Claim
22 words
The method of claim 7 wherein the decalcified freeze-dried bone has a particle size in the range of 149 to 590 μm.
Claim 10
Dependent Claim
21 words
The method of claim 8 wherein the decalcified freeze-dried bone has a particle size in the range of 200 to 400μm.
Claim 11
Dependent Claim
37 words
The method of claim 2 wherein the amount of decalcified freeze-dried bone, having a particle size in the range of 200 to 400 μm, is about 50 percent by weight and the copolymer is 50:50 poly(L)(-)lactide co-glycolide.
Claim 12
Dependent Claim
29 words
A pharmaceutical composition useful in promoting the healing of broken osseous tissue comprising decalcified freeze-dried bone incorporated into a biodegradable polymeric matrix comprised of a copolymer of poly(L)(-)lactide co-glycolide.
Claim 13
Dependent Claim
29 words
A pharmaceutical composition useful in promoting the healing of broken osseous tissue comprising decalcified freeze-dried bone incorporated into a biodegradable polymeric matrix comprised of a copolymer of poly(L)(-)lactide co-glycolide.
Claim 14
Dependent Claim
19 words
The composition of claim 11 wherein said bone is cortical bone which was decalcified in 0.6 normal hydrochloric acid.
Claim 15
Dependent Claim
24 words
The composition of claim 12 wherein the amount of decalcified freeze-dried bone is about 40 to 60 percent by weight of said polymeric matrix.
Claim 16
Dependent Claim
24 words
The composition of claim 13 wherein the amount of decalcified freeze-dried bone is about 45 to 55 percent by weight of said polymeric matrix.
Claim 17
Dependent Claim
22 words
The composition of claim 14 wherein the amount of decalcified freeze-dried bone is about 50 percent by weight of said polymeric matrix.
Claim 18
Dependent Claim
12 words
The composition of claim 15 wherein the copolymer is 50:50 poly(L)(-)lactide co-glycolide.
Claim 19
Dependent Claim
22 words
The composition of claim 16 wherein the decalcified freeze-dried bone has a particle size in the range of 149 to 590 μm.
Claim 20
Dependent Claim
22 words
The composition of claim 16 wherein the decalcified freeze-dried bone has a particle size in the range of 200 to 400 μm.
Claim 21
Dependent Claim
32 words
The composition of claim 18 wherein said bone is cortical bone which was decalcified in 0.6 normal hydrochloric acid, and incorporated into said copolymer in the amount of 50 percent by weight.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-01-19 | 1990-07-21 | 1991-01-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-01-19 | 1994-07-21 | 1995-01-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-01-19 | 1998-07-21 | 1999-01-20 | $7700.00 | Window Closed / Lapsed |