US4485097A
Expired / Lapsed
US
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Bone-equivalent and method for preparation thereof
Assignee: Massachusetts Institute of Technology
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Filing: 1983-05-25
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Granted: 1984-11-27
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Expires: 2003-05-25
Abstract
Abstract A bone-equivalent, useful in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by fibroblast cells and containing demineralized bone powder.
Inventors
- 👤 Eugene Bell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:28
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61F; A61F2/00; A61L27/3641; A61L27/3645; A61L27/365; A61L27/40; A61L27/44; A61F2/02; A61F2/10; A61F2/105; A61F2/28; A61F2002/2835; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2430/00; A61L2430/02; Y; Y10; Y10S; Y10S623/00; Y10S623/915; Y10S623/916; Y10S623/917; Y10S623/919
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
16 words
A bone-equivalent comprising a hydrated collagen lattice containing deminerlized bone powder and contracted with fibroblast cells.
Claim 2
Dependent Claim
16 words
A bone-equivalent comprising a hydrated collagen lattice containing deminerlized bone powder and contracted with fibroblast cells.
Claim 3
Independent Claim
61 words
A method of forming a bone-equivalent, comprising: a. combining a collagen solution with demineralized bone powder and fibroblast cells under conditions to form a gel mixture having demineralized bone powder and fibroblast cells dispersed within said gel mixture; b. maintaining the gel mixture prepared in step (a) under conditions which permit the contraction of said gel mixture to form a bone-equivalent.
Claim 4
Independent Claim
61 words
A method of forming a bone-equivalent, comprising: a. combining a collagen solution with demineralized bone powder and fibroblast cells under conditions to form a gel mixture having demineralized bone powder and fibroblast cells dispersed within said gel mixture; b. maintaining the gel mixture prepared in step (a) under conditions which permit the contraction of said gel mixture to form a bone-equivalent.
Claim 5
Dependent Claim
9 words
A bone-equivalent prepared by the method of claim 2.
References Cited (Backward Citations)
US4314380A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-11-27 | 1988-05-28 | 1988-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-11-27 | 1992-05-28 | 1992-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-11-27 | 1996-05-28 | 1996-11-27 | $7700.00 | Window Closed / Lapsed |