US5053049A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Flexible prostheses of predetermined shapes and process for making same
Assignee: Baxter International Inc
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Filing: 1985-05-29
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Granted: 1991-10-01
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Expires: 2005-05-29
Abstract
Abstract Flexible prostheses of predetermined shapes are derived from bone. The process includes machining of a bone segment into the desired shape, demineralization to impart the desired degree of flexibility, and tanning to render the material non-antigenic, biocompatible, and stabilized.
Inventors
- 👤 Todd D. Campbell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 09:44
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61F; A61F2/00; A61F2/02; A61F2/18; A61F2/28; A61F2/2803; A61K; A61K35/00; A61K35/12; A61K35/32; A61L2/00; A61L2/16; A61L2/18; A61L2/26; A61L2/28; A61L27/3683; A61F2002/183; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/30004; A61F2002/30059; A61F2310/00; A61F2310/00005; A61F2310/00359
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
72 words
A method of producing a flexible, biocompatible, and non-antigenic prosthesis of a precise, intricate shape, for the replacement of a cartilaginous body part, the method comprising: a) machining a bone segment into a desired precise, intricate shape which substantially corresponds to the shape of the cartilaginous body part which the prosthesis is to replace, b) selectively demineralizing said bone segment to achieve the desired degree of flexibility, c) tanning said bone segment.
Claim 2
Independent Claim
72 words
A method of producing a flexible, biocompatible, and non-antigenic prosthesis of a precise, intricate shape, for the replacement of a cartilaginous body part, the method comprising: a) machining a bone segment into a desired precise, intricate shape which substantially corresponds to the shape of the cartilaginous body part which the prosthesis is to replace, b) selectively demineralizing said bone segment to achieve the desired degree of flexibility, c) tanning said bone segment.
Claim 3
Dependent Claim
13 words
The method of claim 1 wherein the bone segment is tanned with glutaraldehyde.
Claim 4
Dependent Claim
20 words
The method of claim 1 additionally comprising extracting the bone segment with an organic solvent to increase the matrix porosity.
Claim 5
Independent Claim
21 words
The method of claims 1 or 3 additionally comprising treating the bone segment with a protease to increase the matrix porosity.
Claim 6
Independent Claim
13 words
The method of claims 1, 2, or 3 additionally comprising sterilizing the prosthesis.
Claim 7
Dependent Claim
38 words
The method of claim 2, wherein the bone segment is treated with glutaraldehyde under tanning conditions effective in cross-linking available proteins to a degree sufficient to stabilize and strengthen the bone and to render it biocompatible and non-antigenic.
Claim 8
Dependent Claim
24 words
The method of claim 6 wherein tanning is accomplished by submerging the bone segment in a buffered solution comprising 0.2% to 0.8% (w/v) glutaraldehyde.
Claim 9
Dependent Claim
20 words
The method of claim 7 wherein the bone segment is submerged in a buffered solution comprising about 0.6% (w/v) glutaraldehyde.
Claim 10
Independent Claim
22 words
The method of claims 6, 7 or 8 wherein the bone is tanned with glutaraldehyde for a minimum of about one month.
Claim 11
Dependent Claim
22 words
The method of claim 1 wherein the bone segment is derived from the condylar region of an allogenic or xenogenic long bone.
Claim 12
Dependent Claim
20 words
The method of claim 1 wherein demineralizing the bone segment is accomplished by submersion in a solution comprising an acid.
Claim 13
Dependent Claim
10 words
The method of claim 11 wherein the acid is HCl.
Claim 14
Dependent Claim
14 words
The method of claim 11 wherein said solution additionally comprises up to 1% EDTA.
Claim 15
Dependent Claim
23 words
The method of claim 1 additionally comprising submerging the bone segment in ethanol to defat it and to remove machine oils and debris.
Claim 16
Dependent Claim
9 words
A prosthesis produced by the method of claim 1.
Claim 17
Dependent Claim
22 words
The method of claim 1, wherein, in step (a) the bone segment is machined to the shape of a natural outer ear.
Claim 18
Dependent Claim
24 words
The method of claim 1, wherein , in step (a), the bone segment is machined to the shape of a natural chin augmentation implant.
Claim 19
Dependent Claim
22 words
The method of claim 1, wherein, in step (a), the bone segment is machined to the shape of a natural nose tip.
Claim 20
Dependent Claim
22 words
The method of claim 1, wherein, in step (a) the bone segment is machined to the shape of a natural spinal disc.
Claim 21
Dependent Claim
9 words
A prosthesis produced by the method of claim 16.
Claim 22
Dependent Claim
9 words
A prosthesis produced by the method of claim 17.
Claim 23
Dependent Claim
9 words
A prosthesis produced by the method of claim 18.
Claim 24
Dependent Claim
9 words
A prosthesis produced by the method of claim 19.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-09-30 | 1995-04-01 | 1995-10-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-09-30 | 1999-04-01 | 1999-10-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-09-30 | 2003-04-01 | 2003-10-01 | $7700.00 | Window Closed / Lapsed |