Patent US5792478A successfully refreshed from Google Patents.
US5792478A
Expired / Lapsed
US
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Tissue injectable composition and method of use
Assignee: Carbon Medical Technologies Inc
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Filing: 1996-07-08
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Granted: 1998-08-11
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Expires: 2016-07-08
Abstract
Abstract An improved biocompatible composition consisting of physiologically stable beads or particles carried in a lubricative suspension, solution, other fluid or gel. The composition is intended to be delivered into the body through a small-bored needle, cannula, or other catheter into a tissue site for the purpose of augmenting the tissue. In particular, the composition is useful for augmenting tissue in the area of the cardiac orifice of the stomach to reduce gastric reflux, in the area of the internal or external sphincter of the anal canal to reduce fecal incontinence or in the area of urethral tissue for the purpose of treating urinary incontinence.
Inventors
- 👤 Timothy P. Lawin
- 👤 Dean Klein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:47
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/501; A61F; A61F2/00; A61F2/0059; A61L; A61L27/00; A61L27/02; A61L27/08; A61L27/10; A61L27/105; A61L27/28; A61L27/30; A61L27/303; A61L27/50; A61F2/0004; A61F2310/00; A61F2310/00389; A61F2310/00574
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
85 words
An injectable, biocompatible composition for tissue augmentation comprising: a plurality of discrete particles in a carrier, wherein each particle includes a substrate particle with a carbon coating over the surface thereof, each of said substrate particles manufactured from a compound selected from the group consisting of aluminum oxide and carbon, and have an average transverse cross sectional dimension of between 100 and 1,000 microns, further, wherein the carrier is a biocompatible medium having sufficient fluidity to carry and deliver the particles, and has lubricative qualities.
Claim 2
Dependent Claim
85 words
An injectable, biocompatible composition for tissue augmentation comprising: a plurality of discrete particles in a carrier, wherein each particle includes a substrate particle with a carbon coating over the surface thereof, each of said substrate particles manufactured from a compound selected from the group consisting of aluminum oxide and carbon, and have an average transverse cross sectional dimension of between 100 and 1,000 microns, further, wherein the carrier is a biocompatible medium having sufficient fluidity to carry and deliver the particles, and has lubricative qualities.
Claim 3
Dependent Claim
12 words
The composition of claim 1 wherein said carbon coating is isotropic carbon.
Claim 4
Dependent Claim
13 words
The composition of claim 1 wherein said carbon coating is pyrolytic, isotropic carbon.
Claim 5
Dependent Claim
14 words
The composition of claim 1 wherein said carbon coating is a smooth surface film.
Claim 6
Dependent Claim
23 words
The composition of claim 1 wherein said substrate particles are of rounded shape and said dimension is between 200 microns and 500 microns.
Claim 7
Dependent Claim
23 words
The composition of claim 1 wherein said substrate particles are of rounded shape and said dimension is between 251 microns and 300 microns.
Claim 8
Dependent Claim
19 words
The composition of claim 1 wherein said average transverse cross section dimension is between 251 microns and 300 microns.
Claim 9
Dependent Claim
53 words
An injectable, biocompatible composition for tissue augmentation comprising: a plurality of discrete particles of pyrolytic carbon in a carrier, and having an average transverse cross sectional dimension of between 100 and 1,000 microns and the carrier is a biocompatible medium having sufficient fluidity to carry and deliver the particles, and has lubricative qualities.
Claim 10
Dependent Claim
53 words
An injectable, biocompatible composition for tissue augmentation comprising: a plurality of discrete particles of pyrolytic carbon in a carrier, and having an average transverse cross sectional dimension of between 100 and 1,000 microns and the carrier is a biocompatible medium having sufficient fluidity to carry and deliver the particles, and has lubricative qualities.
Claim 11
Dependent Claim
74 words
An injectable, biocompatible composition for tissue augmentation comprising: a plurality of discrete particles in a carrier, wherein each of the particles includes a substrate particle with a carbon coating over the surface thereof and have an average transverse cross sectional dimension of between 100 and 1,000 microns and the carrier is a biocompatible medium having sufficient fluidity to carry and deliver the particles, wherein said carrier is a solution, suspension, or gel of polysaccharides.
Claim 12
Dependent Claim
74 words
An injectable, biocompatible composition for tissue augmentation comprising: a plurality of discrete particles in a carrier, wherein each of the particles includes a substrate particle with a carbon coating over the surface thereof and have an average transverse cross sectional dimension of between 100 and 1,000 microns and the carrier is a biocompatible medium having sufficient fluidity to carry and deliver the particles, wherein said carrier is a solution, suspension, or gel of polysaccharides.
Claim 13
Dependent Claim
12 words
The composition of claim 9 wherein said polysaccharides are linear, unbranched polysaccharides.
Claim 14
Dependent Claim
17 words
The composition of claim 9 wherein said carrier is a solution, suspension, or gel of methyl cellulose.
Claim 15
Dependent Claim
10 words
The method of claim 9 wherein said carrier is β-glucan.
Claim 16
Independent Claim
69 words
A method for augmenting tissue in a human patient comprising injecting into a tissue site in the patient a composition comprising a plurality of discrete, carbon or carbon-coated particles having an average, transverse, cross-sectional dimension of between 100 and 1,000 microns in a biocompatible carrier having sufficient fluidity to carry and deliver the particles and has lubricative qualities, wherein the tissue site is the coronary orifice to the stomach.
Claim 17
Independent Claim
69 words
A method for augmenting tissue in a human patient comprising injecting into a tissue site in the patient a composition comprising a plurality of discrete, carbon or carbon-coated particles having an average, transverse, cross-sectional dimension of between 100 and 1,000 microns in a biocompatible carrier having sufficient fluidity to carry and deliver the particles and has lubricative qualities, wherein the tissue site is the coronary orifice to the stomach.
Claim 18
Dependent Claim
10 words
The method of claim 13 wherein said carrier is β-glucan.
Claim 19
Independent Claim
66 words
A method for augmenting tissue in a human patient comprising injecting into a tissue site in the patient a composition comprising a plurality of discrete, carbon or carbon-coated particles having an average, transverse, cross-sectional dimension of between 100 and 1,000 microns in a biocompatible carrier having sufficient fluidity to carry and deliver the particles and has lubricative qualities, wherein the tissue site is the anal canal.
Claim 20
Independent Claim
66 words
A method for augmenting tissue in a human patient comprising injecting into a tissue site in the patient a composition comprising a plurality of discrete, carbon or carbon-coated particles having an average, transverse, cross-sectional dimension of between 100 and 1,000 microns in a biocompatible carrier having sufficient fluidity to carry and deliver the particles and has lubricative qualities, wherein the tissue site is the anal canal.
Claim 21
Dependent Claim
18 words
The method of claim 15 wherein the tissue site is the internal sphincter muscle of the anal canal.
Claim 22
Dependent Claim
18 words
The method of claim 15 wherein the tissue site is the external sphincter muscle of the anal canal.
Claim 23
Dependent Claim
23 words
The method of claim 15 wherein said substrate particles are of rounded shape and said dimension is between 200 microns and 500 microns.
Claim 24
Dependent Claim
23 words
The method of claim 15 wherein said substrate particles are of rounded shape and said dimension is between 251 microns and 300 microns.
References Cited (Backward Citations)
US3638649A
Cited
US3657744A
Cited
US3783868A
Cited
US3977896A
Cited
US4197846A
Cited
US4129470A
Cited
US4239492A
Cited
US4240794A
Cited
US4424208A
Cited
US4527293A
Cited
US4469676A
Cited
US4703108A
Cited
US4563350A
Cited
US5001169A
Cited
US4795467A
Cited
US4992226A
Cited
US4776890A
Cited
US4803075A
Cited
US4773393A
Cited
US4865602A
Cited
US4902511A
Cited
US4863732A
Cited
US5011494A
Cited
US5376375A
Cited
US5328955A
Cited
US5306500A
Cited
US5258028A
Cited
US5116387A
Cited
US5158573A
Cited
US5007940A
Cited
US5256418A
Cited
US5399351A
Cited
US5204382A
Cited
US5352715A
Cited
US5480644A
Cited
US5336263A
Cited
US5407445A
Cited
US5451406A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-08-10 | 2002-02-09 | 2002-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-08-10 | 2006-02-09 | 2006-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-08-10 | 2010-02-09 | 2010-08-11 | $7700.00 | Window Closed / Lapsed |