Patent US5714159A successfully refreshed from Google Patents.
US5714159A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
Assignee: Poly Med Inc
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Filing: 1996-10-31
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Granted: 1998-02-03
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Expires: 2016-10-31
Abstract
Abstract The present invention provides novel hydrogel-forming, self-solvating, absorbable polyester copolymers capable of selective, segmental association into compliant hydrogels upon contacting an aqueous environment. Methods of using the novel polyester copolymers of the invention in humans are also disclosed for providing a protective barrier to prevent post-surgical adhesion, treatment of defects in conduits such as blood vessels, and controlled release of a biologically active agent for modulating cellular events such as wound healing and tissue regeneration or therapeutic treatment of diseases such as infection of the periodontium, dry socket, bone, skin, vaginal, and nail infections
Inventors
- 👤 Shalaby W. Shalaby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 01:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K47/00; A61K47/30; A61K47/34; A61L; A61L31/00; A61L31/04; A61L31/06; A61L31/14; A61L31/145; C; C08; C08G; C08G63/00; C08G63/66; C08G63/664
Claims Analysis
Total Claims: 37
Claim 1
Independent Claim
64 words
A composition comprising: a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment, wherein said copolymer is an extrudable liquid which is injectable into a biological site and is obtained by combining a high molecular weight sample of said copolymer with a plasticizer; and a biologically active agent associated with said copolymer.
Claim 2
Dependent Claim
64 words
A composition comprising: a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment, wherein said copolymer is an extrudable liquid which is injectable into a biological site and is obtained by combining a high molecular weight sample of said copolymer with a plasticizer; and a biologically active agent associated with said copolymer.
Claim 3
Dependent Claim
10 words
The copolymer of claim 1, wherein said copolymer is carboxy-terminated.
Claim 4
Dependent Claim
16 words
The copolymer of claim 1, wherein said agent is deposited on an absorbable, microparticulate solid carrier.
Claim 5
Dependent Claim
12 words
The copolymer of claim 3, wherein said carrier is a microporous carrier.
Claim 6
Dependent Claim
44 words
A composition comprising: a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment; and an absorbable, microparticulate, solid carrier associated with said copolymer, said carrier having a biologically active agent deposited thereon.
Claim 7
Dependent Claim
44 words
A composition comprising: a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment; and an absorbable, microparticulate, solid carrier associated with said copolymer, said carrier having a biologically active agent deposited thereon.
Claim 8
Dependent Claim
21 words
The composition of claim 5, wherein said copolymer comprises a hydrophobic polyester block X covalently bonded to a hydrophilic block Y.
Claim 9
Dependent Claim
12 words
The composition of claim 5, wherein said agent is a therapeutic agent.
Claim 10
Dependent Claim
12 words
The composition of claim 5, wherein said carrier is a microporous carrier.
Claim 11
Dependent Claim
56 words
A composition comprising: a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment; a low molecular weight component associated with said copolymer; and an absorbable, microparticulate solid carrier associated with said copolymer and said component, said carrier having a biologically active agent deposited thereon.
Claim 12
Dependent Claim
56 words
A composition comprising: a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment; a low molecular weight component associated with said copolymer; and an absorbable, microparticulate solid carrier associated with said copolymer and said component, said carrier having a biologically active agent deposited thereon.
Claim 13
Dependent Claim
21 words
The composition of claim 9, wherein said copolymer comprises a hydrophobic polyester block X covalently bonded to a hydrophilic block Y.
Claim 14
Dependent Claim
12 words
The composition of claim 9, wherein said agent is a therapeutic agent.
Claim 15
Dependent Claim
14 words
The composition of claim 9, wherein said low molecular weight component is a plasticizer.
Claim 16
Dependent Claim
25 words
The composition of claim 12, wherein said plasticizer comprises said polymer wherein the hydrophilic block Y to hydrophobic block X ratio is greater than 1.
Claim 17
Dependent Claim
31 words
A pharmaceutical formulation comprising a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment and a pharmaceutically acceptable carrier.
Claim 18
Dependent Claim
31 words
A pharmaceutical formulation comprising a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment and a pharmaceutically acceptable carrier.
Claim 19
Dependent Claim
15 words
A vaccine formulation comprising the pharmaceutical formulation of claim 14 and a pharmaceutically acceptable carrier.
Claim 20
Independent Claim
51 words
A method of treating diseases of the oral cavity in a person suffering from such diseases comprising placing into the periodontal pocket or around said pocket of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 21
Independent Claim
51 words
A method of treating diseases of the oral cavity in a person suffering from such diseases comprising placing into the periodontal pocket or around said pocket of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 22
Independent Claim
62 words
A method of treating post-surgical adhesion in a person suffering from post-surgical adhesion comprising placing at the site of post-surgical adhesion of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment, thereby generating a barrier film or membrane at said site for treatment of said post-surgical adhesion.
Claim 23
Independent Claim
62 words
A method of treating post-surgical adhesion in a person suffering from post-surgical adhesion comprising placing at the site of post-surgical adhesion of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment, thereby generating a barrier film or membrane at said site for treatment of said post-surgical adhesion.
Claim 24
Independent Claim
60 words
A method of treating traumatized tissues in a person having traumatized tissues comprising placing at said traumatized tissue site of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment, thereby generating a barrier film or membrane at said site for treatment of the traumatized tissue.
Claim 25
Independent Claim
60 words
A method of treating traumatized tissues in a person having traumatized tissues comprising placing at said traumatized tissue site of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment, thereby generating a barrier film or membrane at said site for treatment of the traumatized tissue.
Claim 26
Independent Claim
60 words
A method of treating compromised wounds in a person having compromised wounds comprising placing at said compromised wound site of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment, thereby generating a barrier film or membrane at said site for treatment of the compromised wound.
Claim 27
Independent Claim
60 words
A method of treating compromised wounds in a person having compromised wounds comprising placing at said compromised wound site of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment, thereby generating a barrier film or membrane at said site for treatment of the compromised wound.
Claim 28
Independent Claim
46 words
A method of treating mucus membrane infections in a person suffering from mucus membrane infections comprising placing at the infection site of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 29
Independent Claim
46 words
A method of treating mucus membrane infections in a person suffering from mucus membrane infections comprising placing at the infection site of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 30
Independent Claim
52 words
A method of, coating, sealing, plugging, or filling percutaneous, intracutaneous, ophthalmic, vascular, oral, orthopedic, or abdominal sites comprising placing at the percutaneous, intracutaneous, ophthalmic, vascular, oral, orthopedic, or abdominal site a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 31
Independent Claim
52 words
A method of, coating, sealing, plugging, or filling percutaneous, intracutaneous, ophthalmic, vascular, oral, orthopedic, or abdominal sites comprising placing at the percutaneous, intracutaneous, ophthalmic, vascular, oral, orthopedic, or abdominal site a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 32
Independent Claim
56 words
A method of treating cutaneous, transcutaneous, intracutaneous, or percutaneous diseases or infections in a person suffering from such diseases or infections comprising placing at the site of the disease or infection of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 33
Independent Claim
56 words
A method of treating cutaneous, transcutaneous, intracutaneous, or percutaneous diseases or infections in a person suffering from such diseases or infections comprising placing at the site of the disease or infection of said person a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 34
Dependent Claim
26 words
A biomedical barrier comprising a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 35
Dependent Claim
26 words
A biomedical barrier comprising a hydrogel-forming, self-solvating absorbable polyester copolymer capable of selective, segmental association into a compliant hydrogel mass on contact with an aqueous environment.
Claim 36
Dependent Claim
13 words
The biomedical barrier of claim 23, wherein said barrier is a sterilized barrier.
Claim 37
Dependent Claim
43 words
The biomedical barrier of claim 23 for use in treating a person suffering from a condition selected from the group consisting of post-surgical adhesion, defects in conduits, tissue wounds, tissue regeneration and diseases of the periodontium, dry socket, bone, skin, and vaginal infections.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-02-02 | 2001-08-04 | 2002-02-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-02-02 | 2005-08-04 | 2006-02-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-02-02 | 2009-08-04 | 2010-02-03 | $7700.00 | Window Closed / Lapsed |