US4919939A
Expired / Lapsed
US
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Periodontal disease treatment system
Assignee: TECHNICAL CHEMICALS AND PRODUCTS INC
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Filing: 1988-07-08
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Granted: 1990-04-24
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Expires: 2008-07-08
Abstract
Abstract A controlled release drug delivery system for placement in the periodontal pocket, gingival sulcus, tooth socket, wound or other cavity within the mouth. The system incorporates drug-containing microparticles in a fluid carrier medium, and is effective in the environment of use for up to 30 days.
Inventors
- 👤 Richard W. Baker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:58
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063; A61K6/00; A61K6/30; A61K6/60; A61K6/69; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/1652; C; C08; C08L; C08L1/00; C08L1/08; C08L1/26; C08L1/28; C08L1/286
Claims Analysis
Total Claims: 50
Claim 1
Independent Claim
97 words
A controlled drug delivery system for placement in a periodontal pocket, comprising: (a) a plurality of discrete microparticles, between 10 and 500 microns in diameter, comprising a drug and a polymer containing said drug, wherein when said microparticles are placed in an environment of use, said drug is released at a controlled rate by a combination of diffusion of said drug through said polymer and erosion of said polymer; and (b) a fluid suspending medium for said microparticles; said drug delivery system remaining active in the periodontal pocket for a period of between one and thirty days.
Claim 2
Dependent Claim
97 words
A controlled drug delivery system for placement in a periodontal pocket, comprising: (a) a plurality of discrete microparticles, between 10 and 500 microns in diameter, comprising a drug and a polymer containing said drug, wherein when said microparticles are placed in an environment of use, said drug is released at a controlled rate by a combination of diffusion of said drug through said polymer and erosion of said polymer; and (b) a fluid suspending medium for said microparticles; said drug delivery system remaining active in the periodontal pocket for a period of between one and thirty days.
Claim 3
Dependent Claim
23 words
The drug delivery system of claim 1, wherein said drug is a prophylactic agent chosen from the group consisting of calcium and fluoride.
Claim 4
Dependent Claim
23 words
The drug delivery system of claim 1, wherein said drug is an antiseptic chosen from the group consisting of chlorhexidine and tibezonium iodide.
Claim 5
Dependent Claim
13 words
The drug delivery system of claim 1, wherein said drug is an antibiotic.
Claim 6
Dependent Claim
22 words
The drug delivery system of claim 4, wherein said antibiotic is chosen from the group consisting of aminoglycosides, macrolides, penicillins and cephalosporins.
Claim 7
Dependent Claim
21 words
The drug delivery system of claim 4, wherein said antibiotic is chosen from the group consisting of tetracycline and tetracycline hydrochloride.
Claim 8
Dependent Claim
14 words
The drug delivery system of claim 1, wherein said drug is a local anaesthetic.
Claim 9
Dependent Claim
15 words
The drug delivery system of claim 7, wherein said local anaesthetic is lidocaine or procaine.
Claim 10
Dependent Claim
13 words
The drug delivery system of claim 1, wherein said drug is an anti-inflammatory.
Claim 11
Dependent Claim
23 words
The drug delivery system of claim 9, wherein said anti-inflammatory is chosen from the group consisting of ketorolac, naproxen, diclofenac sodium and flurbiprofen.
Claim 12
Dependent Claim
15 words
The drug delivery system of claim 1, wherein said drug possesses activity against collagen-destructive enzymes.
Claim 13
Dependent Claim
24 words
The drug delivery system of claim 11, wherein said drug is chosen from the group consisting of tetracyclines and sanguinarine, its compounds and derivatives.
Claim 14
Dependent Claim
26 words
A method for controlled delivery of a drug to a cavity within the mouth, comprising inserting into said cavity the drug delivery system of claim 1.
Claim 15
Dependent Claim
11 words
The method of claim 13, wherein said cavity is a wound.
Claim 16
Dependent Claim
15 words
The method of claim 13, wherein said cavity is a socket created by tooth extraction.
Claim 17
Dependent Claim
12 words
The method of claim 13, wherein said cavity is a periodontal pocket.
Claim 18
Dependent Claim
12 words
The method of claim 13, wherein said cavity is a gingival sulcus.
Claim 19
Dependent Claim
94 words
A controlled drug delivery system for placement in a periodontal pocket, comprising: (a) a plurality of discrete microparticles, between 10 and 500 microns in diameter, comprising a drug and a polymer containing said drug, said drug being essentially insoluble in said polymer, wherein when said microparticles are placed in an environment of use, said drug is released at a controlled rate by erosion of said polymer; and (b) a fluid suspending medium for said microparticles; said drug delivery system remaining active in the periodontal pocket for a period of between one and thirty days.
Claim 20
Dependent Claim
94 words
A controlled drug delivery system for placement in a periodontal pocket, comprising: (a) a plurality of discrete microparticles, between 10 and 500 microns in diameter, comprising a drug and a polymer containing said drug, said drug being essentially insoluble in said polymer, wherein when said microparticles are placed in an environment of use, said drug is released at a controlled rate by erosion of said polymer; and (b) a fluid suspending medium for said microparticles; said drug delivery system remaining active in the periodontal pocket for a period of between one and thirty days.
Claim 21
Dependent Claim
23 words
The drug delivery system of claim 18, wherein said drug is a prophylactic agent chosen from the group consisting of calcium and fluoride.
Claim 22
Dependent Claim
23 words
The drug delivery system of claim 18, wherein said drug is an antiseptic chosen from the group consisting of chlorhexidine and tibezonium iodide.
Claim 23
Dependent Claim
13 words
The drug delivery system of claim 18, wherein said drug is an antibiotic.
Claim 24
Dependent Claim
22 words
The drug delivery system of claim 21, wherein said antibiotic is chosen from the group consisting of aminoglycosides, macrolides, penicillins and cephalosporins.
Claim 25
Dependent Claim
21 words
The drug delivery system of claim 21, wherein said antibiotic is chosen from the group consisting of tetracycline and tetracycline hydrochloride.
Claim 26
Dependent Claim
14 words
The drug delivery system of claim 18, wherein said drug is a local anaesthetic.
Claim 27
Dependent Claim
15 words
The drug delivery system of claim 24, wherein said local anaesthetic is lidocaine or procaine.
Claim 28
Dependent Claim
13 words
The drug delivery system of claim 18, wherein said drug is an anti-inflammatory.
Claim 29
Dependent Claim
23 words
The drug delivery system of claim 26, wherein said anti-inflammatory is chosen from the group consisting of ketorolac, naproxen, diclofenac sodium and flurbiprofen.
Claim 30
Dependent Claim
15 words
The drug delivery system of claim 18, wherein said drug possesses activity against collagen-destructive enzymes.
Claim 31
Dependent Claim
24 words
The drug delivery system of claim 28, wherein said drug is chosen from the group consisting of tetracyclines and sanguinarine, its compounds and derivatives.
Claim 32
Dependent Claim
15 words
The drug delivery system of claim 18, wherein said drug is a tissue growth factor.
Claim 33
Dependent Claim
47 words
The drug delivery system of claim 30, wherein said tissue growth factor is chosen from the group consisting of epidermal growth factors (EGF), human platelet derived TGF-B, endothelial cell growth factors (ECGF), thymocyte-activating factors (TAF), platelet derived growth factors (PDGF), fibroblast growth factor (FGF), fibronectin and laminin.
Claim 34
Dependent Claim
26 words
A method for controlled delivery of a drug to a cavity within the mouth, comprising inserting into said cavity the drug delivery system of claim 18.
Claim 35
Dependent Claim
99 words
A controlled drug delivery system for placement in a periodontal pocket, comprising: (a) a plurality of discrete microparticles, between 10 and 500 microns in diameter, comprising at least 15 vol % drug dispersed in a polymer, said drug being essentially insoluble in said polymer, wherein when said microparticles are placed in an environment of use, said drug is released at a controlled rate by leaching of said drug from said polymer; and (b) a fluid suspending medium for said microparticles; said drug delivery system remaining active in the periodontal pocket for a period of between one and thirty days.
Claim 36
Dependent Claim
99 words
A controlled drug delivery system for placement in a periodontal pocket, comprising: (a) a plurality of discrete microparticles, between 10 and 500 microns in diameter, comprising at least 15 vol % drug dispersed in a polymer, said drug being essentially insoluble in said polymer, wherein when said microparticles are placed in an environment of use, said drug is released at a controlled rate by leaching of said drug from said polymer; and (b) a fluid suspending medium for said microparticles; said drug delivery system remaining active in the periodontal pocket for a period of between one and thirty days.
Claim 37
Dependent Claim
23 words
The drug delivery system of claim 33, wherein said drug is a prophylactic agent chosen from the group consisting of calcium and fluoride.
Claim 38
Dependent Claim
23 words
The drug delivery system of claim 33, wherein said drug is an antiseptic chosen from the group consisting of chlorhexidine and tibezonium iodide.
Claim 39
Dependent Claim
13 words
The drug delivery system of claim 33, wherein said drug is an antibiotic.
Claim 40
Dependent Claim
22 words
The drug delivery system of claim 36, wherein said antibiotic is chosen from the group consisting of aminoglycosides, macrolides, penicillins and cephalosporins.
Claim 41
Dependent Claim
21 words
The drug delivery system of claim 36, wherein said antibiotic is chosen from the group consisting of tetracycline and tetracycline hydrochloride.
Claim 42
Dependent Claim
14 words
The drug delivery system of claim 33, wherein said drug is a local anaesthetic.
Claim 43
Dependent Claim
15 words
The drug delivery system of claim 33, wherein said local anaesthetic is lidocaine or procaine.
Claim 44
Dependent Claim
13 words
The drug delivery system of claim 33, wherein said drug is an anti-inflammatory.
Claim 45
Dependent Claim
23 words
The drug delivery system of claim 41, wherein said anti-inflammatory is chosen from the group consisting of ketorolac, naproxen, diclofenac sodium and flurbiprofen.
Claim 46
Dependent Claim
15 words
The drug delivery system of claim 33, wherein said drug possesses activity against collagen-destructive enzymes.
Claim 47
Dependent Claim
24 words
The drug delivery system of claim 43, wherein said drug is chosen from the group consisting of tetracyclines and sanguinarine, its compounds and derivatives.
Claim 48
Dependent Claim
15 words
The drug delivery system of claim 33, wherein said drug is a tissue growth factor.
Claim 49
Dependent Claim
47 words
The drug delivery system of claim 45, wherein said tissue growth factor is chosen from the group consisting of epidermal growth factors (EGF), human platelet derived TGF-B, endothelial cell growth factors (ECGF), thymocyte-activating factors (TAF), platelet derived growth factors (PDGF), fibroblast growth factor (FGF), fibronectin and laminin.
Claim 50
Dependent Claim
26 words
A method for controlled delivery of a drug to a cavity within the mouth, comprising inserting into said cavity the drug delivery system of claim 33.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-04-23 | 1993-10-23 | 1994-04-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-04-23 | 1997-10-23 | 1998-04-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-04-23 | 2001-10-23 | 2002-04-24 | $7700.00 | Window Closed / Lapsed |