US5366733A
Expired / Lapsed
US
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Method for the treatment of periodontal disease by sustained delivery of a therapeutic agent to the periodontal pocket, and composition of matter therefor
Assignee: Wyeth Holdings LLC
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Filing: 1991-05-28
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Granted: 1994-11-22
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Expires: 2011-05-28
Abstract
Abstract Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer. Apparatus and methods are also provided for the dispensing of the dry microparticles to the periodontal pocket whereby they become tacky and adhere to the involved tissue so as to induce long term therapeutic benefits.
Inventors
- 👤 Nancy S. Brizzolara
- 👤 Michael G. Lanzilotti
- 👤 James R. Lawter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 11:36
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61C; A61C19/00; A61C19/06; A61C19/063; A61K9/0012; A61K9/0053; A61K9/0063; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1641; A61K9/1647; A61K9/5005; A61K9/5021; A61K9/5031
Claims Analysis
Total Claims: 38
Claim 1
Independent Claim
77 words
An oral composition adapted for the local administration of a therapeutic agent to the periodontal pocket over an extended period of time, said composition adapted to be administered as a plurality of dry, discrete microparticles, the composition comprising dry microcapsules comprised of: (i) an effective amount of at least one therapeutic agent (ii) said microcapsule being prepared by a phase separation process, said composition having a residual hardening agent content of less than about 3% by weight.
Claim 2
Dependent Claim
77 words
An oral composition adapted for the local administration of a therapeutic agent to the periodontal pocket over an extended period of time, said composition adapted to be administered as a plurality of dry, discrete microparticles, the composition comprising dry microcapsules comprised of: (i) an effective amount of at least one therapeutic agent (ii) said microcapsule being prepared by a phase separation process, said composition having a residual hardening agent content of less than about 3% by weight.
Claim 3
Dependent Claim
68 words
An oral composition as defined in claim 1 wherein said therapeutic agent is selected from an antibacterial, an antibiotic, an antifungal agent, an anti-inflammatory agent, an immunosuppressive agent, an immunostimulatory agent, a dentinal desensitizer, an odor masking agent, an immune reagent, an anesthetic, an antiseptic, a nutritional agent, an antioxidant, a lipopolysaccharide complexing agent, a peroxide, a tissue growth factor, or a mixture of any of the foregoing.
Claim 4
Dependent Claim
16 words
An oral composition as defined in claim 1 wherein the said therapeutic agent has antibiotic activity.
Claim 5
Dependent Claim
23 words
An oral composition as defined in claim 3 wherein said therapeutic agent comprises a tetracycline or a pharmaceutically acceptable salt or hydrate thereof.
Claim 6
Dependent Claim
22 words
An oral composition as defined in claim 4 wherein said therapeutic agent comprises doxycycline or a pharmaceutically acceptable salt or hydrate thereof.
Claim 7
Dependent Claim
22 words
An oral composition as defined in claim 4 wherein said therapeutic agent comprises minocycline or a pharmaceutically acceptable salt or hydrate thereof.
Claim 8
Dependent Claim
52 words
An oral composition as defined in claim 1 wherein said polymer comprises a polymer selected from the group consisting of polyglycolide, poly (1-lactide), poly (dl-lactide), polyglycolide-co-dl-lactide), poly(glycolide-1-lactide), poly (alphahydroxybutyric acid), poly (orthoesters), poly (p-dioxanone) and block copolymers of polyglycolide, trimethylene carbonate and polyethylene oxide or a mixture of any of the foregoing.
Claim 9
Dependent Claim
17 words
An oral composition as defined in claim 1 wherein said polymer becomes tacky upon contact with water.
Claim 10
Dependent Claim
13 words
An oral composition as defined in claim 7 wherein said polymer comprises poly(glycolide-co-dl-lactide).
Claim 11
Dependent Claim
22 words
An oral composition as defined in claim 7 wherein said polymer comprises a block copolymer of polyglycolide, trimethylene carbonate and polyethylene oxide.
Claim 12
Dependent Claim
22 words
An oral composition as defined in claim 1 wherein said microparticles have a diameter of from about 0.1 to about 1000 microns.
Claim 13
Dependent Claim
22 words
An oral composition as defined in claim 11 wherein said microparticles have a diameter of from about 10 to about 200 microns.
Claim 14
Dependent Claim
22 words
An oral composition as defined in claim 12 wherein said microparticles have a diameter of from about 30 to about 120 microns.
Claim 15
Dependent Claim
18 words
An oral composition as defined in claim 1, wherein the phase separation agent is a volatile silicone fluid.
Claim 16
Dependent Claim
23 words
An oral composition as defined in claim 1 wherein said residual hardening agent comprises less than about 1% by weight of said microparticles.
Claim 17
Dependent Claim
30 words
An oral composition as defined in claim 1 wherein said therapeutic agent comprises from about 0.00001 to about 50 parts by weight per 100 parts by weight of said microparticles.
Claim 18
Dependent Claim
30 words
An oral composition as defined in claim 16 wherein said therapeutic agent comprises from about 5 to about 40 parts by weight per 100 parts by weight of said microparticles.
Claim 19
Dependent Claim
30 words
An oral composition as defined in claim 4 wherein said therapeutic agent comprises from about 5 to about 40 parts by weight per 100 parts by weight of said microparticles.
Claim 20
Dependent Claim
47 words
An oral composition as defined in claim 1 wherein said microparticles comprise from about 20 to about 30 parts by weight of minocycline HCl or doxycycline hyclate and from about 70 to about 80 parts by weight of poly(glycolide-co-dl-lactide) per 100 parts by weight of said microparticles.
Claim 21
Independent Claim
113 words
A method of alleviating dental diseases comprising administering between the gum and teeth of a patient in need of such treatment, an effective amount of a plurality of dry discrete microparticles which comprise: (i) an effective amount of at least one therapeutic agent dispersed in (ii) a matrix comprising a biocompatible and biodegradable polymer said composition being adapted to be administered as a plurality of dry, discrete microcapsules comprised of an effective amount of at least one therapeutic agent said microcapsule being prepared by a phase separation process wherein the phase separation agent is a volatile silicone fluid, said composition having a residual hardening agent content of less than about 3% by weight.
Claim 22
Independent Claim
113 words
A method of alleviating dental diseases comprising administering between the gum and teeth of a patient in need of such treatment, an effective amount of a plurality of dry discrete microparticles which comprise: (i) an effective amount of at least one therapeutic agent dispersed in (ii) a matrix comprising a biocompatible and biodegradable polymer said composition being adapted to be administered as a plurality of dry, discrete microcapsules comprised of an effective amount of at least one therapeutic agent said microcapsule being prepared by a phase separation process wherein the phase separation agent is a volatile silicone fluid, said composition having a residual hardening agent content of less than about 3% by weight.
Claim 23
Dependent Claim
17 words
A method as defined in claim 20 wherein the dental diseases to be treated are periodontal diseases.
Claim 24
Dependent Claim
67 words
A method as defined in claim 20 wherein said therapeutic agent is selected from an antibacterial, an antibiotic, an antifungal agent, an anti-inflammatory agent, an immunosuppressive agent, an immunostimulatory agent, a dentinal desensitizer, an odor masking agent, an immune reagent, an anesthetic, an antiseptic, a nutritional agent, an antioxidant, a lipopolysaccharide complexing agent, a peroxide, a tissue growth factor or a mixture of any of the foregoing.
Claim 25
Dependent Claim
14 words
A method as defined in claim 20 wherein said therapeutic agent has antibiotic activity.
Claim 26
Dependent Claim
22 words
A method as defined in claim 23 wherein said therapeutic agent comprises a tetracycline or a pharmaceutically acceptable salt or hydrate thereof.
Claim 27
Dependent Claim
21 words
A method as defined in claim 24 wherein said therapeutic agent comprises doxycycline or a pharmaceutically acceptable salt or hydrate thereof.
Claim 28
Dependent Claim
21 words
A method as defined in claim 24 wherein said therapeutic agent comprises minocycline or a pharmaceutically acceptable salt or hydrate thereof.
Claim 29
Dependent Claim
36 words
A method as defined in claim 20 wherein said polymer is selected from polyglycolide, poly (1-lactide), poly (dl-lactide), poly (glycolide-co-dl-lactide), poly (glycolide-co-dl-1-lactide), poly(alphahyroxybutyric acid), poly (orthoesters), and poly (p-dioxanone) and mixtures of any of the foregoing.
Claim 30
Dependent Claim
17 words
A method as defined in claim 20 wherein said polymeric material becomes tacky upon contact with water.
Claim 31
Dependent Claim
14 words
A method as defined in claim 27 wherein said polymeric material comprises poly (glycolide-co-dllactide).
Claim 32
Dependent Claim
22 words
A method as defined in claim 27 wherein said polymeric material comprises a block copolymer of polyglycolide, trimethylene carbonate and polyethylene oxide.
Claim 33
Dependent Claim
21 words
A method as defined in claim 20 wherein said microparticles have a diameter of from about 0.1 to about 1000 microns.
Claim 34
Dependent Claim
21 words
A method as defined in claim 31 wherein said microparticles have a diameter of from about 10 to about 200 microns.
Claim 35
Dependent Claim
21 words
A method as defined in claim 32 wherein said microparticles have a diameter of from about 30 to about 120 microns.
Claim 36
Dependent Claim
15 words
An oral composition as defined in claim 1, wherein the phase separation agent is octamethyltetrasiloxane.
Claim 37
Dependent Claim
80 words
An oral composition adapted for the local administration of a therapeutic agent to the periodontal pocket over an extended period of time, said composition adapted to be administered as a plurality of dry, discrete microcapsules comprised of an effective amount of at least one therapeutic agent said microcapsule being prepared by a phase separation process wherein the phase separation agent is a volatile silicone fluid, said composition having a residual hardening agent content of less than about 3% by weight.
Claim 38
Dependent Claim
80 words
An oral composition adapted for the local administration of a therapeutic agent to the periodontal pocket over an extended period of time, said composition adapted to be administered as a plurality of dry, discrete microcapsules comprised of an effective amount of at least one therapeutic agent said microcapsule being prepared by a phase separation process wherein the phase separation agent is a volatile silicone fluid, said composition having a residual hardening agent content of less than about 3% by weight.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-11-21 | 1998-05-23 | 1998-11-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-11-21 | 2002-05-23 | 2002-11-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-11-21 | 2006-05-23 | 2006-11-22 | $7700.00 | Window Closed / Lapsed |