US5135752A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Buccal dosage form
Assignee: Actavis Laboratories UT Inc
•
Filing: 1988-10-14
•
Granted: 1992-08-04
•
Expires: 2008-10-14
Abstract
Abstract A matrix for a buccal dosage form which melts in the oral cavity at body temperature but will not spontaneously deform at higher temperatures encountered in shipment and storage comprises: ______________________________________ Low MW Polyethylene glycol 75-90% (M.P. about 37° C.) Medium to high MW polyethylene glycol 0-4% Long chain saturated carboxylic acid 0-4% Polyethylene oxide 0.1-4% (MW 100,000-5,000,000) Colloidal silica 10-20%. ______________________________________
Inventors
- 👤 Wallace C. Snipes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:32
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/02; A61K9/0012; A61K9/0053; A61K9/006; A61K9/20; A61K9/2004; A61K9/2009; A61K9/2013; A61K9/2022; A61K9/2031
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
68 words
A matrix composition for a buccal dosage form comprising ______________________________________
Low MW Polyethylene glycol
70-90% by weight
having a molecular weight
of about 1000
(M.P. about 37° C.)
Medium to high MW Polyethylene glycol
0-4% by weight
having a molecular weight
of about 3350 to about 8000
Long chain saturated carboxylic acid
0-4% by weight
Polyethylene oxide 0.1-4% by weight
(MW 100,000-5,000,000)
Colloidal silica 10-20% by weight
______________________________________
Claim 2
Dependent Claim
68 words
A matrix composition for a buccal dosage form comprising ______________________________________
Low MW Polyethylene glycol
70-90% by weight
having a molecular weight
of about 1000
(M.P. about 37° C.)
Medium to high MW Polyethylene glycol
0-4% by weight
having a molecular weight
of about 3350 to about 8000
Long chain saturated carboxylic acid
0-4% by weight
Polyethylene oxide 0.1-4% by weight
(MW 100,000-5,000,000)
Colloidal silica 10-20% by weight
______________________________________
Claim 3
Dependent Claim
14 words
The composition of claim 1 wherein said low MW polyethylene glycol is PEG 1000.
Claim 4
Dependent Claim
16 words
The composition of claim 1 wherein said medium to high MW polyethylene glycol is PEG 8000.
Claim 5
Dependent Claim
21 words
The composition of claim 1 wherein said long chain saturated carboxylic acid has 12 to 18 carbon atoms in the chain.
Claim 6
Dependent Claim
14 words
The composition of claim 3 wherein said long chain carboxylic acid is myristic acid.
Claim 7
Dependent Claim
15 words
The composition of claim 1 wherein said polyethylene oxide has a MW of about 5,000,000.
Claim 8
Dependent Claim
22 words
The composition of claim 1 wherein said low molecular weight polyethylene glycol is present in a proportion of about 82.5% by weight.
Claim 9
Dependent Claim
15 words
The composition of claim 7 wherein said low molecular weight polyethylene glycol is PEG 1000.
Claim 10
Dependent Claim
23 words
The composition of claim 1 wherein said medium to high molecular weight PEG is present in a proportion of about 0.5% by weight.
Claim 11
Dependent Claim
16 words
The composition of claim 9 wherein said medium to high molecular weight PEG is PEG 8000.
Claim 12
Dependent Claim
22 words
The composition of claim 1 wherein said long chain saturated carboxylic acid is present in a proportion of about 0.5% by weight.
Claim 13
Dependent Claim
21 words
The composition of claim 11 wherein said long chain saturated carboxylic acid has 12 to 18 carbon atoms in the chain.
Claim 14
Dependent Claim
14 words
The composition of claim 12 wherein said long chain carboxylic acid is myristic acid.
Claim 15
Dependent Claim
19 words
The composition of claim 1 wherein said polyethylene oxide is present in a proportion of about 0.5% by weight.
Claim 16
Dependent Claim
16 words
The composition of claim 1 wherein said polyethylene oxide has a molecular weight of about 5,000,000.
Claim 17
Dependent Claim
22 words
The composition of claim 15 wherein said colloidal silica is present in a proportion of about 12% to about 18% by weight.
Claim 18
Dependent Claim
19 words
The composition of claim 16 wherein said colloidal silica is present in a proportion of about 16% by weight.
Claim 19
Dependent Claim
40 words
A matrix composition for a buccal dosage form comprising ______________________________________
Polyethylene glycol (MW 1000)
82.5% by weight
Polyethylene glycol (MW 8,000)
0.5% by weight
Myristic acid 0.5% by weight
Polyethylene oxide 0.5% by weight
Colloidal silica 16.0% by weight
______________________________________
Claim 20
Dependent Claim
40 words
A matrix composition for a buccal dosage form comprising ______________________________________
Polyethylene glycol (MW 1000)
82.5% by weight
Polyethylene glycol (MW 8,000)
0.5% by weight
Myristic acid 0.5% by weight
Polyethylene oxide 0.5% by weight
Colloidal silica 16.0% by weight
______________________________________
References Cited (Backward Citations)
US3932613A
Cited
EP0001822A2
Cited
US4450877A
Cited
DE3217071A1
Cited
US4629621A
Cited
US4744976A
Cited
US4774074A
Cited
US4806337A
Cited
EP0215635A2
Cited
US4764378A
Cited
USRE33093E
Cited
US4837025A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-08-04 | 1996-02-03 | 1996-08-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-08-04 | 2000-02-03 | 2000-08-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-08-04 | 2004-02-03 | 2004-08-04 | $7700.00 | Window Closed / Lapsed |