US4938763A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biodegradable in-situ forming implants and methods of producing the same
Assignee: Tolmar Therapeutics Inc
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Filing: 1988-10-03
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Granted: 1990-07-03
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Expires: 2008-10-03
Abstract
Abstract A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
Inventors
- 👤 Richard L. Dunn
- 👤 James P. English
- 👤 Donald R. Cowsar
- 👤 David P. Vanderbilt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:11
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61F; A61F2/00; A61K47/00; A61K47/30; A61K47/34; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/44; A61L15/62; A61L24/00; A61L24/001; A61L24/0015; A61L24/0026; A61L24/0042; A61L24/04; A61L24/046; A61L24/06; A61L26/00; A61L26/0009; A61L26/0019; A61L26/0061; A61L26/0066; A61L26/0076; A61L26/009; A61L27/00; A61L27/14; A61L27/16; A61L27/18; A61L27/26; A61L27/28; A61L27/34; A61L27/50; A61L27/54; A61L27/58; A61F2/02; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30316; A61F2002/30535; A61F2002/30581; A61F2002/30583; A61F2210/00; A61F2210/0004; A61F2210/0085; A61L2300/00; A61L2300/20; A61L2300/25; A61L2300/252; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/41; A61L2300/60; A61L2300/602; A61L2300/604; Y; Y10; Y10S; Y10S525/00; Y10S525/937
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
49 words
A method of forming an implant in-situ, in a living body, comprising the steps of: (a) dissolving a non-reactive, water-insoluble polymer in a biocompatible, water-soluble solvent to form a liquid; (b) placing said liquid within said body; and (c) allowing said solvent to dissipate to produce a solid implant.
Claim 2
Independent Claim
49 words
A method of forming an implant in-situ, in a living body, comprising the steps of: (a) dissolving a non-reactive, water-insoluble polymer in a biocompatible, water-soluble solvent to form a liquid; (b) placing said liquid within said body; and (c) allowing said solvent to dissipate to produce a solid implant.
Claim 3
Dependent Claim
87 words
The method of claim 1, wherein said solvent is comprised of a binary solvent mixture having a first solvent capable of dissolving said polymer and a second solvent incapable of dissolving said polymer, said first and second solvents being present in said mixture at a ratio ouch that said polymer is soluble therein, so that said polymer is precipitated from said liquid upon the placing of said liquid within said animal, thereby resulting in an increase in said ratio of said second solvent to said first solvent.
Claim 4
Dependent Claim
15 words
The method of claim 1, and further comprising delivering said liquid in-situ through a needle.
Claim 5
Dependent Claim
28 words
The method of claim 3, wherein said polymer is a lactide polymer and said second solvent is selected from the group consisting of water, ethanol and propylene glycol.
Claim 6
Dependent Claim
44 words
The method of claim 1, and further comprising the step of adding an effective amount of biologically active agent to said liquid to provide an implant which releases said agent by diffusion, erosion or a combination of diffusion and erosion as said plant biodegrades.
Claim 7
Dependent Claim
17 words
The method of claim 5, wherein said implant is formed in a periodontal pocket in said body.
Claim 8
Dependent Claim
20 words
The method of claim 6, wherein said biologically-active agent is selected from the group consisting of benzophenanthridine alkaloid and tetracycline.
Claim 9
Dependent Claim
13 words
The method of claim 5, wherein said biologically-active agent comprises a benzophenanthridine alkaloid.
Claim 10
Dependent Claim
11 words
The method of claim 8, wherein said alkaloid comprises sanguinarine chloride.
Claim 11
Dependent Claim
10 words
The method of claim 8, wherein said alkaloid comprises ethoxydihydrosanguinarine.
Claim 12
Dependent Claim
12 words
The method of claim 5, wherein said biologically-active agent comprises tetracycline base.
Claim 13
Dependent Claim
12 words
The method of claim 5, wherein said biologically-active agent comprises tetracycline hydrochloride.
Claim 14
Dependent Claim
16 words
A biodegradable drug delivery implant for a body produced according to the method of claim 5.
Claim 15
Dependent Claim
10 words
The method of claim 1, wherein said polymer is biodegradable.
Claim 16
Dependent Claim
50 words
The method of claim 1, wherein said polymer is selected from the group consisting of polylactides, polyglycolides, polycaprolactones, polydioxanones, polycarbonates, polyhydroxybutyrates, polyalkylene oxalates, polyanhydrides, polyamides, polyesteramides, polyurethanes, polyacetals, polyketals, polyorthocarbonates, polyphosphazenes, polyhydroxyvalerates, polyalkylene succinates, poly(malic acid), poly(amino acids), chitin, chitosan, and polyorthoesters, and copolymers, terpolymers and combinations and mixtures thereof.
Claim 17
Dependent Claim
22 words
The method of claim 1, wherein said polymer is selected from the group consisting of polylactides, polycaprolactones and copolymers thereof with glycolide.
Claim 18
Dependent Claim
43 words
The method of claim 1, wherein said solvent is selected from the group consisting of N-methyl-2-pyrrolidone, 2-pyrrolidone, ethanol, propylene glycol, acetone, ethyl acetate, methyl acetate, methyl ethyl ketone, dimethylformamide, dimethyl sulfoxide, tetrahydrofuran, caprolactam, decylmethylsulfoxide, oleic acid and 1-dodecylazacycloheptan-2-one and combinations and mixtures thereof.
Claim 19
Dependent Claim
27 words
The method of claim 1, wherein said solvent is selected from the group consisting of N-methyl-2-pyrrolidone, 2-pyrrolidone, dimethyl sulfoxide and acetone, and a combination or mixture thereof.
Claim 20
Dependent Claim
14 words
A biodegradable implant for a body produced according to the method of claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-07-02 | 1994-01-01 | 1994-07-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-07-02 | 1998-01-01 | 1998-07-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-07-02 | 2002-01-01 | 2002-07-03 | $7700.00 | Window Closed / Lapsed |