US5707647A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Adjunctive polymer system for use with medical device
Assignee: Tolmar Therapeutics Inc
•
Filing: 1996-11-14
•
Granted: 1998-01-13
•
Expires: 2016-11-14
Abstract
Abstract A medical device which is a surgically implantable device coated with an adjunctive polymer system. The adjunctive polymer system forms a solid matrix when introduced into a human or animal body. The adjunctive polymer system can contain a drug or a medicament which is released over time from the solid matrix. The adjunctive polymer system contacts body tissue into which the surgically implantable device is implanted.
Inventors
- 👤 Richard L. Dunn
- 👤 Gerald L. Yewey
- 👤 Jeffrey L. Southard
- 👤 John E. Urheim
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 15:12
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/44; A61L15/62; A61L15/64; A61L17/00; A61L17/06; A61L24/00; A61L24/001; A61L24/0042; A61L26/00; A61L26/0061; A61L26/0066; A61L26/0076; A61L26/009; A61L27/00; A61L27/50; A61L27/54; A61L27/58; A61L29/00; A61L29/14; A61L29/148; A61L29/16; A61L31/00; A61L31/14; A61L31/148; A61L31/16; A61L2300/00; A61L2300/40; A61L2300/43; A61L2300/60; A61L2300/602; A61L2300/606; A61L2300/62; Y; Y10; Y10S; Y10S528/00; Y10S528/905; Y10S602/00; Y10S602/904
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
143 words
A method for sealing a wound in an internal tissue or organ, comprising: (a) applying an adjunctive polymer system to a fibrous wound dressing to form a coated wound dressing, wherein the adjunctive polymer system comprises a mixture of a pharmaceutically acceptable, biodegradable thermoplastic polymer that is insoluble in water or body fluids, and a biocompatible organic solvent which solubilizes the polymer and is miscible to dispersible in water or body fluids, the polymer having such a molecular weight and such a proportion in the solvent that the solvent is capable of dissipating or dispersing from the polymer system into surrounding tissue fluid whereupon the thermoplastic polymer forms a solid matrix; (b) applying the coated wound dressing to the wound in the internal tissue or organ; and (c) allowing the adjunctive polymer system to coagulate to a solid matrix to seal the wound.
Claim 2
Independent Claim
143 words
A method for sealing a wound in an internal tissue or organ, comprising: (a) applying an adjunctive polymer system to a fibrous wound dressing to form a coated wound dressing, wherein the adjunctive polymer system comprises a mixture of a pharmaceutically acceptable, biodegradable thermoplastic polymer that is insoluble in water or body fluids, and a biocompatible organic solvent which solubilizes the polymer and is miscible to dispersible in water or body fluids, the polymer having such a molecular weight and such a proportion in the solvent that the solvent is capable of dissipating or dispersing from the polymer system into surrounding tissue fluid whereupon the thermoplastic polymer forms a solid matrix; (b) applying the coated wound dressing to the wound in the internal tissue or organ; and (c) allowing the adjunctive polymer system to coagulate to a solid matrix to seal the wound.
Claim 3
Dependent Claim
22 words
The method according to claim 1, wherein a biologically active agent is incorporated into the dressing, the adjunctive polymer system, or both.
Claim 4
Dependent Claim
20 words
The method according to claim 1, further comprising prior to step (b), applying the adjunctive polymer system to the wound.
Claim 5
Dependent Claim
26 words
The method according to claim 3, wherein the adjunctive polymer system is applied to the wound by brushing, spraying, dipping, extruding, injecting, or a combination thereof.
Claim 6
Dependent Claim
22 words
The method according to claim 1, further comprising prior to step (b), applying to the wound, a device for holding tissue together.
Claim 7
Dependent Claim
26 words
The method according to claim 5, wherein the adjunctive polymer system is applied to the device to seal an opening made by the wound closing means.
Claim 8
Dependent Claim
46 words
The method according to claim 5, further comprising applying the adjunctive system to the wound before or after applying the wound closing means to enhance adhesion of the wound healing means to the wound, administering a biologically active agent to the wound, or a combination thereof.
Claim 9
Independent Claim
141 words
A method for sealing a wound in an internal tissue or organ, comprising: (a) applying an adjunctive polymer system to the wound, wherein the adjunctive polymer system comprises a mixture of a pharmaceutically acceptable, biodegradable thermoplastic polymer that is insoluble in water or body fluids, and a biocompatible organic solvent which solubilizes the polymer and is miscible to dispersible in water or body fluids, the polymer having such a molecular weight and such a proportion in the solvent that the solvent is capable of dissipating or dispersing from the polymer system into surrounding tissue fluid whereupon the thermoplastic polymer forms a solid matrix; (b) applying a fibrous wound dressing onto the adjunctive polymer system on the wound; and (c) allowing the adjunctive polymer system to coagulate to a solid matrix to seal the wound in conjunction with the fibrous wound dressing.
Claim 10
Independent Claim
141 words
A method for sealing a wound in an internal tissue or organ, comprising: (a) applying an adjunctive polymer system to the wound, wherein the adjunctive polymer system comprises a mixture of a pharmaceutically acceptable, biodegradable thermoplastic polymer that is insoluble in water or body fluids, and a biocompatible organic solvent which solubilizes the polymer and is miscible to dispersible in water or body fluids, the polymer having such a molecular weight and such a proportion in the solvent that the solvent is capable of dissipating or dispersing from the polymer system into surrounding tissue fluid whereupon the thermoplastic polymer forms a solid matrix; (b) applying a fibrous wound dressing onto the adjunctive polymer system on the wound; and (c) allowing the adjunctive polymer system to coagulate to a solid matrix to seal the wound in conjunction with the fibrous wound dressing.
Claim 11
Dependent Claim
20 words
The method of claim 8, further comprising before or after step (b), applying the adjunctive polymer system to the dressing.
Claim 12
Dependent Claim
26 words
The method according to claim 1, wherein the fibrous wound dressing is selected from the group consisting of fabric, mesh, webbing, cloth, netting or combinations thereof.
Claim 13
Dependent Claim
25 words
The method according to claim 1, wherein the internal tissue or organ is selected from the group consisting of an artery, vein, liver or pancreas.
References Cited (Backward Citations)
US2155658A
Cited
US3463158A
Cited
US3887699A
Cited
US3773919A
Cited
US3991766A
Cited
US4076798A
Cited
US4122129A
Cited
US4105034A
Cited
US4181983A
Cited
US4793336A
Cited
US4631188A
Cited
EP0159293A1
Cited
DD281908A7
Cited
US4780320A
Cited
US4981696A
Cited
US4913903A
Cited
US5013553A
Cited
US5278201A
Cited
US4938763A
Cited
US4938763B1
Cited
US5340849A
Cited
WO1990003768A1
Cited
US5278202A
Cited
US5324520A
Cited
US5486547A
Cited
US5077049A
Cited
WO1991001126A1
Cited
US5368859A
Cited
US5324519A
Cited
WO1992000718A1
Cited
US5173301A
Cited
US5266359A
Cited
EP0537559A1
Cited
EP0539751A1
Cited
EP0560014A1
Cited
US5461124A
Cited
EP0649662A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-01-12 | 2001-07-14 | 2002-01-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-01-12 | 2005-07-14 | 2006-01-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-01-12 | 2009-07-14 | 2010-01-13 | $7700.00 | Window Closed / Lapsed |