US5013553A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Drug delivery devices
Assignee: Vipont Pharmaceutical Inc
•
Filing: 1989-08-29
•
Granted: 1991-05-07
•
Expires: 2009-08-29
Abstract
Abstract Drug delivery devices and techniques are described for use in treatment of periodontal disease and the like. The delivery device includes benzo (c) phenanthridine alkaloid in a bioerodable and biocompatible material. The alkaloid is slowly released from the bioerodable material in the oral cavity. The bioerodable material may be polymeric and may be natural or synthetic. The delivery device may be inserted subgingivally (e.g., in a periodontal pocket) where the alkaloid is released slowly over a period of days.
Inventors
- 👤 G. Lee Southard
- 👤 Ronald J. Harkrader
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 13:17
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K6/00; A61K6/30; A61K6/80; A61K6/884; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
125 words
A bioerodable composition suitable for placement subgingivally in a periodontal pocket, said composition comprising: (a) bioerodable, biocompatible, sustained release, polymeric material; and (b) an active agent consisting essentially of a benzophenanthridine alkaloid; wherein said alkaloid is releasably contained in said material in a manner such that said alkaloid is slowly released from said composition so as to maintain an effective concentration of said alkaloid for a period of several days in said pocket; wherein said alkaloid is present in said composition in an amount of at least 1% by weight; and wherein an aliquot of said composition suitably sized for the periodontal pocket and containing 500 micrograms of said alkaloid has a release rate in the range of about 30 to 100 micrograms per day.
Claim 2
Dependent Claim
125 words
A bioerodable composition suitable for placement subgingivally in a periodontal pocket, said composition comprising: (a) bioerodable, biocompatible, sustained release, polymeric material; and (b) an active agent consisting essentially of a benzophenanthridine alkaloid; wherein said alkaloid is releasably contained in said material in a manner such that said alkaloid is slowly released from said composition so as to maintain an effective concentration of said alkaloid for a period of several days in said pocket; wherein said alkaloid is present in said composition in an amount of at least 1% by weight; and wherein an aliquot of said composition suitably sized for the periodontal pocket and containing 500 micrograms of said alkaloid has a release rate in the range of about 30 to 100 micrograms per day.
Claim 3
Dependent Claim
38 words
A composition in accordance with claim 1, wherein said alkaloid is present in an amount of about 1 to 80% by weight and, correspondingly, said material is present in an amount of about 99 to 20% by weight.
Claim 4
Dependent Claim
13 words
A composition in accordance with claim 1, wherein said biocompatible material is bioabsorbable.
Claim 5
Dependent Claim
25 words
A composition in accordance with claim 1, wherein said biocompatible material is selected from the group consisting of polylactides, polyglycolides, polycaprolactones, polyanhydrides, and mixtures thereof.
Claim 6
Dependent Claim
24 words
A composition in accordance with claim 1, wherein said alkaloid is selected from the group consisting of sanguinarine, sanguirubine, sanguilutine, chelirubine, chelerythrine, and chelilutine.
Claim 7
Dependent Claim
16 words
A composition in accordance with claim 5, wherein said alkaloid is in the iminium ion form.
Claim 8
Dependent Claim
27 words
A composition in accordance with claim 5, wherein said alkaloid is selected from the group consisting of alkanolamine, alcoholate, hydroxylate, sulfate, nitrate, chloride, acetate, citrate, and tartrate.
Claim 9
Independent Claim
134 words
A method for treating periodontal disease in a subject comprising applying to said subject, subgingivally in a periodontal pocket, a bioerodable composition comprising: (a) bioerodable, biocompatible, sustained release, polymeric material; and (b) an active agent consisting essentially of a benzophenanthridine alkaloid; wherein said alkaloid is releasably contained in said material in a manner such that said alkaloid is slowly released from said composition so as to maintain an effective concentration of said alkaloid for a period of several days in said pocket; wherein said alkaloid is present in said composition in an amount of at least 1% by weight; and wherein an aliquot of said composition suitably sized for the periodontal pocket and containing 500 micrograms of said alkaloid has a release rate in the range of about 30 to 100 micrograms per day.
Claim 10
Independent Claim
134 words
A method for treating periodontal disease in a subject comprising applying to said subject, subgingivally in a periodontal pocket, a bioerodable composition comprising: (a) bioerodable, biocompatible, sustained release, polymeric material; and (b) an active agent consisting essentially of a benzophenanthridine alkaloid; wherein said alkaloid is releasably contained in said material in a manner such that said alkaloid is slowly released from said composition so as to maintain an effective concentration of said alkaloid for a period of several days in said pocket; wherein said alkaloid is present in said composition in an amount of at least 1% by weight; and wherein an aliquot of said composition suitably sized for the periodontal pocket and containing 500 micrograms of said alkaloid has a release rate in the range of about 30 to 100 micrograms per day.
Claim 11
Dependent Claim
38 words
A method in accordance with claim 8, wherein said alkaloid is present in an amount of about 1 to 80% by weight and, correspondingly, said material is present in an amount of about 99 to 20% by weight.
Claim 12
Dependent Claim
13 words
A method in accordance with claim 8, wherein said biocompatible material is bioabsorbable.
Claim 13
Dependent Claim
25 words
A method in accordance with claim 8, wherein said biocompatible material is selected from the group consisting of polylactides, polyglycolides, polycaprolactones, polyanhydrides, and mixtures thereof.
Claim 14
Dependent Claim
24 words
A method in accordance with claim 8, wherein said alkaloid is selected from the group consisting of sanguinarine, sanguirubine, sanguilutine, chelirubine, chelerythrine, and chelilutine.
Claim 15
Dependent Claim
12 words
A method in accordance with claim 8, wherein said subject is human.
Claim 16
Dependent Claim
13 words
A method in accordance with claim 8, wherein said subject is an animal.
Claim 17
Independent Claim
129 words
A method for treating bacterial infections in periodontal tissues comprising applying to said tissues, subgingivally, a composition comprising: (a) bioerodable, biocompatible, sustained release, polymeric material; and (b) an active agent consisting essentially of a benzophenanthridine alkaloid; wherein said alkaloid is releasably contained in said material in a manner such that said alkaloid is slowly released from said composition so as to maintain an effective concentration of said alkaloid for a period of several days in said tissues; wherein said alkaloid is present in said composition in an amount of at least 1% by weight; and wherein an aliquot of said composition suitably sized for a periodontal pocket and containing 500 micrograms of said alkaloid has a release rate in the range of about 30 to 100 micrograms per day.
Claim 18
Independent Claim
129 words
A method for treating bacterial infections in periodontal tissues comprising applying to said tissues, subgingivally, a composition comprising: (a) bioerodable, biocompatible, sustained release, polymeric material; and (b) an active agent consisting essentially of a benzophenanthridine alkaloid; wherein said alkaloid is releasably contained in said material in a manner such that said alkaloid is slowly released from said composition so as to maintain an effective concentration of said alkaloid for a period of several days in said tissues; wherein said alkaloid is present in said composition in an amount of at least 1% by weight; and wherein an aliquot of said composition suitably sized for a periodontal pocket and containing 500 micrograms of said alkaloid has a release rate in the range of about 30 to 100 micrograms per day.
Claim 19
Dependent Claim
38 words
A method in accordance with claim 15, wherein said alkaloid is present in an amount of about 1 to 80% by weight and, correspondingly, said material is present in an amount of about 99 to 20% by weight.
Claim 20
Dependent Claim
25 words
A method in accordance with claim 15, wherein said biocompatible material is selected from the group consisting of polylactides, polyglycolides, polycaprolactones, polyanhydrides, and mixtures thereof.
Claim 21
Dependent Claim
24 words
A method in accordance with claim 15, wherein said alkaloid is selected from the group consisting of sanguinarine, sanguirubine, sanguilutine, chelirubine, chelerythrine, and chelilutine.
Claim 22
Dependent Claim
13 words
A method in accordance with claim 15, wherein said alkaloid comprises sanguinarine ethanolate.
Claim 23
Dependent Claim
16 words
A method in accordance with claim 15, wherein said alkaloid is in the iminium ion form.
Claim 24
Dependent Claim
27 words
A method in accordance with claim 15, wherein said alkaloid is selected from the group consisting of alkanolamine, alcoholate, hydroxylate, sulfate, nitrate, chloride, acetate, citrate, and tartrate.
Claim 25
Independent Claim
132 words
A method for treating inflammatory infections in periodontal tissues in a subject comprising applying to said subject, subgingivally, a composition comprising: (a) bioerodable, biocompatible, sustained release material; and (b) an active agent consisting essentially of a benzophenanthridine alkaloid; wherein said alkaloid is releasably contained in said material in a manner such that said alkaloid is slowly released from said composition so as to maintain an effective concentration of said alkaloid for a period of several days adjacent to said tissues; wherein said alkaloid is present in said composition in an amount of at least 1% by weight; and wherein an aliquot of said composition suitably sized for a periodontal pocket and containing 500 micrograms of said alkaloid has a release rate in the range of about 30 to 100 micrograms per day.
Claim 26
Independent Claim
132 words
A method for treating inflammatory infections in periodontal tissues in a subject comprising applying to said subject, subgingivally, a composition comprising: (a) bioerodable, biocompatible, sustained release material; and (b) an active agent consisting essentially of a benzophenanthridine alkaloid; wherein said alkaloid is releasably contained in said material in a manner such that said alkaloid is slowly released from said composition so as to maintain an effective concentration of said alkaloid for a period of several days adjacent to said tissues; wherein said alkaloid is present in said composition in an amount of at least 1% by weight; and wherein an aliquot of said composition suitably sized for a periodontal pocket and containing 500 micrograms of said alkaloid has a release rate in the range of about 30 to 100 micrograms per day.
Claim 27
Dependent Claim
23 words
A composition according to claim 1 wherein an effective concentration of the alkaloid is maintained for a period of 7 to 14 days.
Claim 28
Dependent Claim
14 words
A composition according to claim 4 wherein the bioerodable, biocompatible material comprises a polylactide.
Claim 29
Dependent Claim
27 words
A method for treating periodontal disease according to claim 8 wherein an effective concentration of the alkaloid is maintained for a period of 7 to 14 days.
Claim 30
Dependent Claim
18 words
A method for treating periodontal disease according to claim 11 wherein the bioerodable, biocompatible material comprises a polylactide.
Claim 31
Dependent Claim
30 words
A method for treating bacterial infections in periodontal tissue according to claim 15 wherein an effective concentration of the alkaloid is maintained for a period of 7 to 14 days.
Claim 32
Dependent Claim
21 words
A method for treating bacterial infections in periodontal tissue according to claim 17 wherein the bioerodable, biocompatible material comprises a polylactide.
References Cited (Backward Citations)
US4406881A
Cited
US4599228A
Cited
US4568535A
Cited
US4515771A
Cited
US4685883A
Cited
US4764377A
Cited
US4722948A
Cited
US4780320A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-05-06 | 1994-11-05 | 1995-05-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-05-06 | 1998-11-05 | 1999-05-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-05-06 | 2002-11-05 | 2003-05-07 | $7700.00 | Window Closed / Lapsed |