US5340849A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biodegradable in-situ forming implants and methods for producing the same
Assignee: Tolmar Therapeutics Inc
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Filing: 1991-12-23
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Granted: 1994-08-23
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Expires: 2011-12-23
Abstract
Abstract A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.
Inventors
- 👤 Richard L. Dunn
- 👤 James P. English
- 👤 Donald R. Cowsar
- 👤 David D. Vanderbilt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:13
CPC Classifications
A; A61; A61F; A61F2/00; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K47/00; A61K47/30; A61K47/34; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/44; A61L15/62; A61L24/00; A61L24/001; A61L24/0015; A61L24/0026; A61L24/0042; A61L24/04; A61L24/046; A61L24/06; A61L26/00; A61L26/0009; A61L26/0019; A61L26/0061; A61L26/0066; A61L26/0076; A61L26/009; A61L27/00; A61L27/14; A61L27/16; A61L27/18; A61L27/26; A61L27/28; A61L27/34; A61L27/50; A61L27/54; A61L27/58; A61F2/02; A61F2/30; A61F2002/30001; A61F2002/30003; A61F2002/3006; A61F2002/30062; A61F2002/30316; A61F2002/30535; A61F2002/30581; A61F2002/30583; A61F2210/00; A61F2210/0004; A61F2210/0085; A61L2300/00; A61L2300/20; A61L2300/25; A61L2300/252; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/41; A61L2300/60; A61L2300/602; A61L2300/604; Y; Y10; Y10S; Y10S525/00; Y10S525/937
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
88 words
A method of forming a solid implant in-situ within a living body, comprising the steps of: a) mixing together effective amounts of a liquid acrylic-ester-terminated, biodegradable prepolymer of terminal acryloyl groups and a residue of an oligomer having terminal functional groups which react with acryloyl acylating groups and a curing agent to form a mixture in a liquid form; and b) delivering said mixture within said body while said mixture is in a liquid form so as to allow said prepolymer to cure to form said solid implant.
Claim 2
Independent Claim
88 words
A method of forming a solid implant in-situ within a living body, comprising the steps of: a) mixing together effective amounts of a liquid acrylic-ester-terminated, biodegradable prepolymer of terminal acryloyl groups and a residue of an oligomer having terminal functional groups which react with acryloyl acylating groups and a curing agent to form a mixture in a liquid form; and b) delivering said mixture within said body while said mixture is in a liquid form so as to allow said prepolymer to cure to form said solid implant.
Claim 3
Dependent Claim
23 words
The method of claim 1, and further comprising the step of forming said liquid acrylic-ester-terminated biodegradable prepolymer by converting a polyol-terminated biodegradable prepolymer.
Claim 4
Dependent Claim
26 words
The method of claim 2, and further comprising the step of forming said polyol-terminated biodegradable prepolymer by copolymerization of DL-lactide and ε-caprolactone with a polyol initiator.
Claim 5
Dependent Claim
18 words
The method of claim 3, and further comprising the step of adding a catalyst to said copolymerization step.
Claim 6
Dependent Claim
11 words
The method of claim 4, wherein said catalyst is stannous octcate.
Claim 7
Dependent Claim
11 words
The method of claim 4, wherein said catalyst is stannous chloride.
Claim 8
Dependent Claim
26 words
The method of claim 2, and further comprising the step of forming said polyol-terminated biodegradable prepolymer by copolymerization of L-lactide and ε-caprolactone with a polyol initiator.
Claim 9
Dependent Claim
18 words
The method of claim 7, and further comprising the step of adding a catalyst to said copolymerization step.
Claim 10
Dependent Claim
11 words
The method of claim 8, wherein said catalyst is stannous octoate.
Claim 11
Dependent Claim
11 words
The method of claim 8, wherein said catalyst is stannous chloride.
Claim 12
Dependent Claim
11 words
The method of claim 1, wherein said curing agent is azobisisobutyronitrile.
Claim 13
Dependent Claim
12 words
The method of claim 1, wherein said curing agent is benzoyl peroxide.
Claim 14
Dependent Claim
45 words
The method of claim 1, and further comprising the step of adding a biologically active agent to said biodegradable prepolymer and curing agent mixture to provide, upon curing, a biodegradable implant which releases said biologically active agent by diffusion or erosion as said implant biodegrades.
Claim 15
Dependent Claim
23 words
The method of claim 1, wherein said delivering step comprises injecting said mixture into said body by means of a syringe and needle.
Claim 16
Dependent Claim
14 words
A biodegradable implant for a body produced according to the method of claim 1.
Claim 17
Independent Claim
58 words
A method of forming a solid biodegradable implant in-situ in a living body, comprising the step of injecting mixture within said body, wherein said liquid comprises effective amounts of a liquid acrylic-ester-terminated biodegradable prepolymer of terminal acryloyl groups and a residue of an oligomer having terminal functional groups which react with acryloyl acylating groups and a curing agent.
Claim 18
Independent Claim
58 words
A method of forming a solid biodegradable implant in-situ in a living body, comprising the step of injecting mixture within said body, wherein said liquid comprises effective amounts of a liquid acrylic-ester-terminated biodegradable prepolymer of terminal acryloyl groups and a residue of an oligomer having terminal functional groups which react with acryloyl acylating groups and a curing agent.
References Cited (Backward Citations)
US4408023A
Cited
US5077049A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-08-22 | 1998-02-21 | 1998-08-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-08-22 | 2002-02-21 | 2002-08-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-08-22 | 2006-02-21 | 2006-08-23 | $7700.00 | Window Closed / Lapsed |