US5665063A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods for application of intraluminal photopolymerized gels
Assignee: Genzyme Corp
•
Filing: 1994-06-24
•
Granted: 1997-09-09
•
Expires: 2014-06-24
Abstract
Abstract Devices for providing polymeric layers on the interior surface of body lumens and spaces are disclosed. The devices can include proximal and distal occlusion elements to define the treatment space and an optical emitter to provide light for a photopolymerization procedure. The devices may include a molding member for providing a thick polymeric gel. Alternatively, devices without a molding member may be used to carry out an interfacial polymerization procedure.
Inventors
- 👤 Laurence A. Roth
- 👤 Stephen J. Herman
- 👤 Farhad Khosravi
- 👤 David Melanson
- 👤 Michael Dumont
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:11
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61M; A61M25/00; A61M25/10; A61M25/1011; A61B; A61B17/00; A61B17/00491; A61F2250/00; A61F2250/0058; A61F2250/0067; A61M25/0067; A61M25/0074; A61M25/0075; A61M2025/0076; A61M2025/1043; A61M2025/1052
Claims Analysis
Total Claims: 44
Claim 1
Independent Claim
181 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: i) an elongated shaft including at least one occlusion element for occluding the body lumen and an injection lumen for injecting a fluent prepolymer material into a space defined at least at one end by the occlusion element; and ii) an optical emitter positioned in the space defined at least at one end by the occlusion element; b) positioning said at least one occlusion element at a desired location in the body lumen; c) positioning the optical emitter at a treatment site; d) actuating said at least one occlusion element to define a treatment space; e) injecting a fluent prepolymer into the treatment space; f) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer; g) deactuating said at least one occlusion element; and, h) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 2
Independent Claim
181 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: i) an elongated shaft including at least one occlusion element for occluding the body lumen and an injection lumen for injecting a fluent prepolymer material into a space defined at least at one end by the occlusion element; and ii) an optical emitter positioned in the space defined at least at one end by the occlusion element; b) positioning said at least one occlusion element at a desired location in the body lumen; c) positioning the optical emitter at a treatment site; d) actuating said at least one occlusion element to define a treatment space; e) injecting a fluent prepolymer into the treatment space; f) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer; g) deactuating said at least one occlusion element; and, h) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein at least one occlusion element comprises an inflatable balloon.
Claim 4
Dependent Claim
26 words
The method of claim 1 wherein the treatment space is flushed with at least one fluid prior to injecting the fluent prepolymer into the treatment space.
Claim 5
Dependent Claim
47 words
The method of claim 1 wherein the device further includes a molding member positioned in the treatment space, and the method further includes the step of using the molding member to form the fluent prepolymer solution into an annular or partially annular layer on the body lumen.
Claim 6
Dependent Claim
13 words
The method of claim 4 wherein the molding member comprises an inflatable balloon.
Claim 7
Dependent Claim
15 words
The method of claim 1 wherein at least one occlusion element comprises a valve-occlusion balloon.
Claim 8
Independent Claim
189 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: I) an elongated shaft including at least one occlusion element for occluding the body lumen and an injection lumen for injecting a fluent prepolymer material into a space defined at least at one end by the occlusion element; and ii) an optical emitter positioned in the space defined at least at one end by the occlusion element; b) positioning said at least one occlusion element at a desired location in the body lumen; c) positioning the optical emitter at a treatment site; d) actuating said at least one occlusion element to define a treatment space and flushing the treatment space with a photoinitiator; e) then injecting a fluent prepolymer into the treatment space; f) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of prepolymer; g) deactuating said at least one occlusion element; and, h) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 9
Independent Claim
189 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: I) an elongated shaft including at least one occlusion element for occluding the body lumen and an injection lumen for injecting a fluent prepolymer material into a space defined at least at one end by the occlusion element; and ii) an optical emitter positioned in the space defined at least at one end by the occlusion element; b) positioning said at least one occlusion element at a desired location in the body lumen; c) positioning the optical emitter at a treatment site; d) actuating said at least one occlusion element to define a treatment space and flushing the treatment space with a photoinitiator; e) then injecting a fluent prepolymer into the treatment space; f) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of prepolymer; g) deactuating said at least one occlusion element; and, h) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 10
Dependent Claim
43 words
The method of claim 7, further comprising removing from the treatment space one of either photoinitiator that is not adsorbed by the body lumen surface or prepolymer that is not polymerized by the light prior to deactuating the at least one occlusion element.
Claim 11
Dependent Claim
15 words
The method of claim 7, wherein at least one occlusion element comprises an inflatable balloon.
Claim 12
Dependent Claim
47 words
The method of claim 7, wherein the device further includes a molding member positioned in the treatment space, and the method further includes the step of using the molding member to form the fluent prepolymer solution into an annular or partially annular layer on the body lumen.
Claim 13
Independent Claim
198 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: i) proximal and distal radially expandable occlusion elements, each being independently actuable and axially movable relative to the other and an injection lumen for injecting a fluent prepolymer material into a space defined between the proximal and distal occlusion elements; and ii) an optical emitter positioned at least partially between the proximal and distal occlusion elements, the emitter being axially movable relative to at least one of the occlusion elements; b) positioning the proximal and distal occlusion elements at a desired location in the body lumen; c) positioning the optical emitter at a treatment site; d) actuating at least one of the proximal and distal occlusion elements to define a treatment space; e) injecting a fluent prepolymer into the treatment space; f) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer; g) deactuating said at least one occlusion element; and, h) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 14
Independent Claim
198 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: i) proximal and distal radially expandable occlusion elements, each being independently actuable and axially movable relative to the other and an injection lumen for injecting a fluent prepolymer material into a space defined between the proximal and distal occlusion elements; and ii) an optical emitter positioned at least partially between the proximal and distal occlusion elements, the emitter being axially movable relative to at least one of the occlusion elements; b) positioning the proximal and distal occlusion elements at a desired location in the body lumen; c) positioning the optical emitter at a treatment site; d) actuating at least one of the proximal and distal occlusion elements to define a treatment space; e) injecting a fluent prepolymer into the treatment space; f) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer; g) deactuating said at least one occlusion element; and, h) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 15
Dependent Claim
17 words
The method of claim 11 wherein at least one of the occlusion elements comprises an inflatable balloon.
Claim 16
Dependent Claim
26 words
The method of claim 11 wherein the treatment space is flushed with at least one fluid prior to injecting the fluent prepolymer into the treatment space.
Claim 17
Dependent Claim
15 words
The method of claim 11 wherein at least one occlusion element comprises a valve-occlusion balloon.
Claim 18
Dependent Claim
44 words
The method of claim 11 wherein the device further includes a molding member positioned in the treatment space, and the method further includes the step of using the molding member to form the fluent prepolymer solution into an annular layer on the body lumen.
Claim 19
Dependent Claim
13 words
The method of claim 15 wherein the molding member comprises an inflatable balloon.
Claim 20
Independent Claim
207 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: I) proximal and distal radially expandable occlusion elements, each being independently actuable and axially movable relative to the other and an injection lumen for injecting a fluent prepolymer material into a space defined between the proximal and distal occlusion elements; and ii) an optical emitter positioned at least partially between the proximal and distal occlusion elements, the emitter being axially movable relative to at least one of the occlusion elements; b) positioning the proximal and distal occlusion elements at a desired location in the body lumen; c) positioning the optical emitter at a treatment site; d) actuating at least one of the proximal and distal occlusion elements to define a treatment space and flushing the treatment space with a photoinitiator; e) then injecting a fluent prepolymer into the treatment space; f) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer; g) deactuating said at least one occlusion element; and, h) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 21
Independent Claim
207 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: I) proximal and distal radially expandable occlusion elements, each being independently actuable and axially movable relative to the other and an injection lumen for injecting a fluent prepolymer material into a space defined between the proximal and distal occlusion elements; and ii) an optical emitter positioned at least partially between the proximal and distal occlusion elements, the emitter being axially movable relative to at least one of the occlusion elements; b) positioning the proximal and distal occlusion elements at a desired location in the body lumen; c) positioning the optical emitter at a treatment site; d) actuating at least one of the proximal and distal occlusion elements to define a treatment space and flushing the treatment space with a photoinitiator; e) then injecting a fluent prepolymer into the treatment space; f) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer; g) deactuating said at least one occlusion element; and, h) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 22
Dependent Claim
43 words
The method of claim 17, further comprising removing from the treatment space one of either photoinitiator that is not absorbed by the body lumen surface or prepolymer that is not polymerized by the light prior to deactuating the at least one occlusion element.
Claim 23
Dependent Claim
17 words
The method fo claim 17, wherein at least one of the occlusion elements comprises an inflatable balloon.
Claim 24
Dependent Claim
44 words
The method of claim 17, wherein the device further includes a molding member positioned in the treatment space, and the method further includes the step of using the molding member to form the fluent prepolymer solution into an annular layer on the body lumen.
Claim 25
Dependent Claim
13 words
The method of claim 20, wherein the molding member comprises an inflatable balloon.
Claim 26
Independent Claim
223 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of; a) providing a device which comprises: i) an elongate tubular sheath having a proximal occlusion element near its distal end; ii) an elongate shaft, axially movable relative to the tubular sheath having a distal occlusion element near its distal end; and iii) an optical emitter positioned at least in part between the proximal and distal occlusion elements, the emitter axially movable relative to at least the proximal occlusion element; b) advancing the elongate member such that the distal occlusion element is positioned at a desired location; c) advancing the tubular sheath relative to the elongate member such that the distal end of the tubular sheath is positioned proximal to the distal end of the elongate member; d) positioning the optical emitter at a treatment site; e) actuating at least one of the proximal and distal occlusion elements to define a treatment space; f) injecting a fluent prepolymer into the treatment space; g) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer; and h) deactuating said at least one occlusion element; and, i) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 27
Independent Claim
223 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of; a) providing a device which comprises: i) an elongate tubular sheath having a proximal occlusion element near its distal end; ii) an elongate shaft, axially movable relative to the tubular sheath having a distal occlusion element near its distal end; and iii) an optical emitter positioned at least in part between the proximal and distal occlusion elements, the emitter axially movable relative to at least the proximal occlusion element; b) advancing the elongate member such that the distal occlusion element is positioned at a desired location; c) advancing the tubular sheath relative to the elongate member such that the distal end of the tubular sheath is positioned proximal to the distal end of the elongate member; d) positioning the optical emitter at a treatment site; e) actuating at least one of the proximal and distal occlusion elements to define a treatment space; f) injecting a fluent prepolymer into the treatment space; g) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer; and h) deactuating said at least one occlusion element; and, i) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 28
Dependent Claim
17 words
The method of claim 22 wherein at least one of the occlusion elements comprises an inflatable balloon.
Claim 29
Dependent Claim
26 words
The method of claim 22 wherein the treatment space is flushed with at least one fluid prior to injecting the fluent prepolymer into the treatment space.
Claim 30
Dependent Claim
21 words
The method of claim 22 wherein the relative distance between the proximal occlusion element and the distal occlusion element is adjustable.
Claim 31
Dependent Claim
15 words
The method of claim 22 wherein at least one occlusion element comprises a valve-occlusion balloon.
Claim 32
Dependent Claim
22 words
The method of claim 22, wherein said elongate shaft is coaxial with said sheath for at least a portion of its length.
Claim 33
Dependent Claim
48 words
The method of claim 22 wherein the device further includes a molding member positioned at least in part in the treatment space, and the method further includes the step of using the molding member to form the fluent prepolymer solution into an annular layer on the body lumen.
Claim 34
Dependent Claim
13 words
The method of claim 28 wherein the molding member comprises an inflatable balloon.
Claim 35
Independent Claim
270 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: I) an elongate tubular sheath having a proxtmal occlusion element near its distal end; ii) an elongate shaft, axially movable relative to the tubular sheath having a distal occlusion element near its distal end; and iii) an optical emitter positioned at least in part between the proximal and distal occlusion elements, the emitter axially movable relative to at least the proximal occlusion element; b) advancing the elongate member such that the distal occlusion element is positioned at a desired location; c) advancing the tubular sheath relative to the elongate member such that the distal end of the tubular sheath is positioned proximal to the distal end of the elongate member; d) positioning the optical emitter at a treatment site; c) advancing the tubular sheath relative to the elongate member such that the distal end of the tubular sheath is positioned proximal to the distal end of the elongate member; d) positioning the optical emitter at a treatment site; e) actuating at least one of the proximal and distal occlusion elements to define a treatment space and flushing the treatment space with a photoinitiator; f) then injecting a fluent prepolymer into the treatment space; g) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer; h) deactuating said at least one occlusion element; and, I) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 36
Independent Claim
270 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: I) an elongate tubular sheath having a proxtmal occlusion element near its distal end; ii) an elongate shaft, axially movable relative to the tubular sheath having a distal occlusion element near its distal end; and iii) an optical emitter positioned at least in part between the proximal and distal occlusion elements, the emitter axially movable relative to at least the proximal occlusion element; b) advancing the elongate member such that the distal occlusion element is positioned at a desired location; c) advancing the tubular sheath relative to the elongate member such that the distal end of the tubular sheath is positioned proximal to the distal end of the elongate member; d) positioning the optical emitter at a treatment site; c) advancing the tubular sheath relative to the elongate member such that the distal end of the tubular sheath is positioned proximal to the distal end of the elongate member; d) positioning the optical emitter at a treatment site; e) actuating at least one of the proximal and distal occlusion elements to define a treatment space and flushing the treatment space with a photoinitiator; f) then injecting a fluent prepolymer into the treatment space; g) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer; h) deactuating said at least one occlusion element; and, I) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 37
Dependent Claim
43 words
The method of claim 30, further comprising removing from the treatment space one of either photoinitiator that is not adsorbed by the body lumen surface or prepolymer that is not polymerized by the light prior to deactuating the at least one occlusion element.
Claim 38
Dependent Claim
17 words
The method of claim 30, wherein at least one of the occlusion elements comprises an inflatable balloon.
Claim 39
Dependent Claim
21 words
The method of claim 30, wherein the relative distance between the proximal occlusion element and the distal occlusion element is adjustable.
Claim 40
Dependent Claim
48 words
The method of claim 30, wherein the device further includes a molding member positioned at least in part in the treatment space, and the method further includes the step of using the molding member to form the fluent prepolymer solution into an annular layer on the body lumen.
Claim 41
Dependent Claim
13 words
The method of claim 34, wherein the molding member comprises an inflatable balloon.
Claim 42
Independent Claim
170 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: i) an elongated shaft including at least one injection lumen for injecting a flushing liquid, a photoinitiator, and a fluent prepolymer material into the body lumen; and ii) an optical emitter positioned adjacent to the surface to be coated; b) guiding the device through a body lumen to position the optical emitter adjacent to the surface to be coated; c) optionally injecting a flushing liquid into the lumen at the surface to be coated; d) injecting a photoinitiator to stain the surface to be coated; e) injecting a fluent prepolymer to contact surfaces stained with the photoinitiator; f) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer and render it non-fluent; and g) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 43
Independent Claim
170 words
A method for providing a polymeric coating on a surface of a body lumen which comprises the steps of: a) providing a device which comprises: i) an elongated shaft including at least one injection lumen for injecting a flushing liquid, a photoinitiator, and a fluent prepolymer material into the body lumen; and ii) an optical emitter positioned adjacent to the surface to be coated; b) guiding the device through a body lumen to position the optical emitter adjacent to the surface to be coated; c) optionally injecting a flushing liquid into the lumen at the surface to be coated; d) injecting a photoinitiator to stain the surface to be coated; e) injecting a fluent prepolymer to contact surfaces stained with the photoinitiator; f) directing light through the optical emitter into the prepolymer to photopolymerize at least a portion of the prepolymer and render it non-fluent; and g) withdrawing the device from the body lumen, thereby leaving a layer of polymeric material on at least a surface of the body lumen.
Claim 44
Dependent Claim
33 words
A method as in claim 36 which further includes the step of injecting a flushing liquid into the lumen at the surface to be coated subsequent to the step of injecting the photoinitiator.
References Cited (Backward Citations)
US3707146A
Cited
US3987000A
Cited
US4080969A
Cited
US4233493A
Cited
US4023559A
Cited
US4118470A
Cited
US4900303A
Cited
US4588395A
Cited
US4190720A
Cited
US4248214A
Cited
US4336809A
Cited
US4385344A
Cited
US4578061A
Cited
US4451568A
Cited
US4573966A
Cited
US4423725A
Cited
US4445892A
Cited
US4496345A
Cited
US4443430A
Cited
US4575181A
Cited
US4799479A
Cited
US4669465A
Cited
US4763653A
Cited
US4824436A
Cited
US4832688A
Cited
US4911163A
Cited
US4846174A
Cited
US4744366A
Cited
WO1988003389A1
Cited
US4846165A
Cited
US4878492A
Cited
EP0402467A1
Cited
US4969912A
Cited
US5080893A
Cited
WO1989012478A1
Cited
US5232444A
Cited
EP0355200A1
Cited
WO1990001969A1
Cited
US5213580A
Cited
US4938763A
Cited
US4938763B1
Cited
US5100429A
Cited
US5324519A
Cited
US5209748A
Cited
US5460610A
Cited
US5306249A
Cited
US5176638A
Cited
WO1991012846A1
Cited
US5328471A
Cited
WO1991017731A1
Cited
US5092841A
Cited
US5199951A
Cited
US5207670A
Cited
US5279546A
Cited
US5292362A
Cited
US5410016A
Cited
US5156613A
Cited
US5169395A
Cited
US5250070A
Cited
WO1992021354A1
Cited
US5147203A
Cited
US5196005A
Cited
WO1993016687A1
Cited
WO1993017669A1
Cited
US5312333A
Cited
US5372585A
Cited
US5257970A
Cited
US5298018A
Cited
WO1994005342A1
Cited
WO1995008289A2
Cited
WO1995009024A1
Cited
US5462529A
Cited
US5454794A
Cited
US5397307A
Cited
US5425723A
Cited
WO1996000102A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-09-08 | 2001-03-10 | 2001-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-09-08 | 2005-03-10 | 2005-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-09-08 | 2009-03-10 | 2009-09-09 | $7700.00 | Window Closed / Lapsed |