US5257970A
Expired / Lapsed
US
⏱️ 0.0 years remaining
In situ photodynamic therapy
Assignee: Health Research Inc
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Filing: 1992-04-09
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Granted: 1993-11-02
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Expires: 2012-04-09
Abstract
Abstract The process of photodynamic therapy (PDT) is conducted by the step of: 1) separately encapsulating at least one activation component for said photodynamic therapy process in a liposome; 2) injecting a photosensitizer into a human or animal host; 3) injecting the liposome encapsulated components systemically into the same human or animal host; and 4) heating the site of the tumor to melt the liposome encapsulated components to permit mixing of the activation components. The mixing of the activation components can result in: a) energy transfer to the previously injected photosensitizer; b) emission of light and absorption of said light by the previously injected photosensitizer; and c) direct formation of at least one cytotoxic species that functions against the tumor. The heating of the site of the tumor is accomplished by one of the following methods: laser, ultra sound, radio-frequency or microwave frequency. Photofrin photosensitizer is a preferred photosensitizer.
Inventors
- 👤 Thomas J. Dougherty
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:11
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/10; A61K9/127; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K31/495; A61K31/50; A61K31/66; A61K41/00; A61K41/0057; A61K41/0071
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
70 words
In the process of photodynamic therapy, the improvement comprising: 1) separately encapsulating at least two activation components for said photodynamic therapy process in a liposome; 2) injecting a photosensitizer into a human or animal host; 3) injecting the liposome encapsulated components systemically into the same human or animal host; and 4) heating the site of the tumor to melt the liposome encapsulated components to permit mixing of the activation components.
Claim 2
Dependent Claim
70 words
In the process of photodynamic therapy, the improvement comprising: 1) separately encapsulating at least two activation components for said photodynamic therapy process in a liposome; 2) injecting a photosensitizer into a human or animal host; 3) injecting the liposome encapsulated components systemically into the same human or animal host; and 4) heating the site of the tumor to melt the liposome encapsulated components to permit mixing of the activation components.
Claim 3
Dependent Claim
21 words
The process of claim 1 wherein the mixing of the activation components results in energy transfer to the previously injected photosensitizer.
Claim 4
Dependent Claim
28 words
The process of claim 1 wherein the mixing of the activation components results in the emission of light and absorption of said light by the previously injected photosensitizer.
Claim 5
Dependent Claim
27 words
The process of claim 1 wherein the mixing of the activation components results in direct formation of at least one cytotoxic species that functions against such tumor.
Claim 6
Dependent Claim
29 words
The process of claim 1 wherein the heating of the site of the tumor is accomplished by one of the following methods: laser, ultra sound, radio-frequency or microwave frequency.
Claim 7
Dependent Claim
22 words
The process of claim 1 wherein the photosensitizer is a material capable of being activated by light emission from a luminescent source.
Claim 8
Dependent Claim
19 words
The process of claim 1 wherein the photosensitizer is a material capable of accepting energy from the activation components.
Claim 9
Dependent Claim
11 words
The process of claim 1 wherein the photosensitizer is a porphyrin.
Claim 10
Dependent Claim
84 words
In the process of photodynamic therapy, the improvement comprising: 1) separately encapsulating at least two activation components for said photodynamic therapy process in a liposome; 2) injecting a photosensitizer which comprises a porphyrin into a human or animal host; 3) injecting the liposome encapsulated components systemically into the same human or animal host; and 4) heating the site of the tumor to melt the liposome encapsulated components to permit mixing of the activation components and generation of light which is absorbed by said photosensitizer.
Claim 11
Dependent Claim
84 words
In the process of photodynamic therapy, the improvement comprising: 1) separately encapsulating at least two activation components for said photodynamic therapy process in a liposome; 2) injecting a photosensitizer which comprises a porphyrin into a human or animal host; 3) injecting the liposome encapsulated components systemically into the same human or animal host; and 4) heating the site of the tumor to melt the liposome encapsulated components to permit mixing of the activation components and generation of light which is absorbed by said photosensitizer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-11-01 | 1997-05-03 | 1997-11-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-11-01 | 2001-05-03 | 2001-11-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-11-01 | 2005-05-03 | 2005-11-02 | $7700.00 | Window Closed / Lapsed |