Patent US5658550A successfully refreshed from Google Patents.
US5658550A
Expired / Lapsed
US
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Non cross-linked synthetic polymers as contrast media for magnetic resonance imaging
Assignee: ImaRx Therapeutics Inc
•
Filing: 1994-05-31
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Granted: 1997-08-19
•
Expires: 2014-05-31
Abstract
Abstract Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents such as paramagnetic, superparamagnetic or proton density contrast agents. Additionally, the polymers or polymer and contrast agent admixtures may be mixed with one or more biocompatible gases to increase the relaxivity of the resultant preparation, and/or with other components. In a preferable embodiment, the contrast medium is hypoosmotic.
Inventors
- 👤 Evan C. Unger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:06
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/101; A61K49/103; A61K49/105; A61K49/12; A61K49/126; A61K49/128; A61K49/18; A61K49/1806; A61K49/1818; A61K49/1821; A61K49/1824; A61K49/1827; A61K49/1833; A61K49/1845; A61K49/1851; A61K49/1863; B; B82; B82Y; B82Y5/00; C; C08; C08L; C08L71/00; C08L71/02; G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 72
Claim 1
Independent Claim
42 words
A contrast medium for use in magnetic resonance imaging of a patient comprising an aqueous solution or suspension of a biocompatible non-cross-linked synthetic polymer in admixture with a contrast agent, wherein the contrast medium is hypoosmotic to bodily fluids of the patient.
Claim 2
Dependent Claim
42 words
A contrast medium for use in magnetic resonance imaging of a patient comprising an aqueous solution or suspension of a biocompatible non-cross-linked synthetic polymer in admixture with a contrast agent, wherein the contrast medium is hypoosmotic to bodily fluids of the patient.
Claim 3
Dependent Claim
19 words
A contrast medium of claim 1 wherein the hypoosmotic contrast medium has an osmolarity of less than 280 milliosmoles/liter.
Claim 4
Dependent Claim
17 words
A contrast medium of claim 2 wherein the osmolarity is between about 200 and about 270 milliosmoles/liter.
Claim 5
Dependent Claim
17 words
A contrast medium of claim 3 wherein the osmolarity is between about 220 and about 260 milliosmoles/liter.
Claim 6
Dependent Claim
17 words
A contrast medium of claim 4 wherein the osmolarity is between about 250 and about 260 milliosmoles/liter.
Claim 7
Dependent Claim
19 words
A contrast medium of claim 1 wherein the polymer has a weight average molecular weight of less than 30,000.
Claim 8
Dependent Claim
26 words
A contrast medium of claim 1 wherein the polymer is selected from the group consisting of polyethylenes, polyoxyethylenes, polypropylenes, pluronic acids, pluronic alcohols, polyvinyls, and polyvinylpyrrolidones.
Claim 9
Dependent Claim
12 words
A contrast medium of claim 1 wherein the polymer is polyethylene glycol.
Claim 10
Dependent Claim
24 words
A contrast medium of claim 1 wherein the contrast agent is selected from the group consisting of paramagnetic, superparamagnetic and proton density contrast agents.
Claim 11
Dependent Claim
23 words
A contrast medium of claim 9 wherein the contrast agent is a paramagnetic contrast agent which is a transition, lanthanide or actinide element.
Claim 12
Dependent Claim
30 words
A contrast medium of claim 10 wherein the paramagnetic contrast agent is selected from the group consisting of Gd(III), Mn(II), Cu(II), Cr(III), Fe(II), Fe(III), Co(II), Er(II), Ni(II), Su(III) and Dy(III).
Claim 13
Dependent Claim
13 words
A contrast medium of claim 11 wherein the paramagnetic contrast agent is Mn(II).
Claim 14
Dependent Claim
11 words
A contrast medium of claim 1 further comprising a suspending agent.
Claim 15
Dependent Claim
74 words
A contrast medium of claim 13 wherein the suspending agent is selected from the group consisting of xanthum gum, acacia, agar, alginic acid, aluminum monostearate, bassorin, karaya, gum arabic, unpurified bentonite, purified bentonite, bentonite magma, calcium carboxymethylcellulose, sodium carboxymethylcellulose, carrageenan, microcrystalline cellulose, dextran, gelatin, guar gum, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, magnesium aluminum silicate, methylcellulose, pectin, casein, gelatin, polyethylene oxide, polyvinyl alcohol, povidone, propylene glycol, alginate, silicon dioxide, silicon dioxide colloidal, alginate, sodium alginate, and tragacanth.
Claim 16
Dependent Claim
13 words
A contrast medium of claim 14 wherein the suspending agent is xanthan gum.
Claim 17
Dependent Claim
12 words
A contrast medium of claim 1 further comprising an osmotically active material.
Claim 18
Dependent Claim
64 words
A contrast medium of claim 16 wherein the osmotically active material is selected from the group consisting of erythrose, threose, ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, idose, galactose, talose, ribulose, fructose, sorbitol, mannitol, sedoheptulose, lactose, sucrose, maltose, cellobiose, glycine, serine, threonine, cystsine, tyrosine, asparagine, glutamine, aspartic acid, glutamic acid, lysine, arginine, histidine, propylene glycol, polypropylene glycol, ethylene glycol, polyethylene glycol and polyvinylpyrrolidone.
Claim 19
Dependent Claim
13 words
A contrast medium of claim 17 wherein the osmotically active material is glycine.
Claim 20
Dependent Claim
24 words
A contrast medium of claim 1 further comprising a pH regulating additive effective to maintain a pH of between about 3 and about 10.
Claim 21
Dependent Claim
23 words
A contrast medium of claim 19 wherein the pH regulating additive is effective to maintain a pH of between about 3 and 8.
Claim 22
Dependent Claim
32 words
A contrast medium of claim 1 further comprising a suspending agent, an osmotically active material, and a pH regulating additive effective to maintain a pH of between about 3 and about 10.
Claim 23
Dependent Claim
21 words
A contrast medium of claim 1 which is a contrast medium for use in imaging a gastrointestinal region of a patient.
Claim 24
Dependent Claim
19 words
A contrast medium of claim 1 which is a contrast medium for use in imaging vasculature of a patient.
Claim 25
Independent Claim
73 words
A method of providing an image of an internal region of a patient comprising (i) administering to the patient a diagnostically effective amount of a contrast medium comprising an aqueous solution or suspension of a biocompatible non-cross-linked synthetic polymer in admixture with a contrast agent, wherein the contrast medium is hypoosmotic to bodily fluids of the patient, and (ii) scanning the patient using magnetic resonance imaging to obtain visible images of the region.
Claim 26
Independent Claim
73 words
A method of providing an image of an internal region of a patient comprising (i) administering to the patient a diagnostically effective amount of a contrast medium comprising an aqueous solution or suspension of a biocompatible non-cross-linked synthetic polymer in admixture with a contrast agent, wherein the contrast medium is hypoosmotic to bodily fluids of the patient, and (ii) scanning the patient using magnetic resonance imaging to obtain visible images of the region.
Claim 27
Dependent Claim
12 words
A method of claim 24 wherein the region is the gastrointestinal region.
Claim 28
Dependent Claim
11 words
A method of claim 24 wherein the region is the vasculature.
Claim 29
Dependent Claim
18 words
A method of claim 24 wherein the hypoosmotic contrast medium has an osmolarity of less than 280 milliosmoles/liter.
Claim 30
Dependent Claim
16 words
A method of claim 27 wherein the osmolarity is between about 200 and about 270 milliosmoles/liter.
Claim 31
Dependent Claim
16 words
A method of claim 28 wherein the osmolarity is between about 220 and about 260 milliosmoles/liter.
Claim 32
Dependent Claim
16 words
A method of claim 29 wherein the osmolarity is between about 250 and about 260 milliosmoles/liter.
Claim 33
Dependent Claim
18 words
A method of claim 24 wherein the polymer has a weight average molecular weight of less than 30,000.
Claim 34
Dependent Claim
25 words
A method of claim 24 wherein the polymer is selected from the group consisting of polyethylenes, polyoxyethylenes, polypropylenes, pluronic acids, pluronic alcohols, polyvinyls, and polyvinylpyrrolidones.
Claim 35
Dependent Claim
11 words
A method of claim 24 wherein the polymer is polyethylene glycol.
Claim 36
Dependent Claim
23 words
A method of claim 24 wherein the contrast agent is selected from the group consisting of paramagnetic, superparamagnetic and proton density contrast agents.
Claim 37
Dependent Claim
22 words
A method of claim 34 wherein the contrast agent is a paramagnetic contrast agent which is a transition, lanthanide or actinide element.
Claim 38
Dependent Claim
29 words
A method of claim 35 wherein the paramagnetic contrast agent is selected from the group consisting of Gd(III), Mn(II), Cu(II), Cr(III), Fe(II), Fe(III), Co(II), Er(II), Ni(II), Eu(III) and Dy(III).
Claim 39
Dependent Claim
12 words
A method of claim 36 wherein the paramagnetic contrast agent is Mn(II).
Claim 40
Dependent Claim
10 words
A method of claim 24 further comprising a suspending agent.
Claim 41
Dependent Claim
73 words
A method of claim 38 wherein the suspending agent is selected from the group consisting of xanthum gum, acacia, agar, alginic acid, aluminum monostearate, bassorin, karaya, gum arabic, unpurified bentonits, purified bentonite, bentonite magna, calcium carboxymethylcellulose, sodium carboxymethylcellulose, carrageenan, microcrystalline cellulose, dextran, gelatin, guar gum, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, magnesium aluminum silicate, methylcellulose, pectin, casein, gelatin, polyethylene oxide, polyvinyl alcohol, povidone, propylene glycol, alginate, silicon dioxide, silicon dioxide colloidal, alginate, sodium alginate, and tragacanth.
Claim 42
Dependent Claim
12 words
A method of claim 39 wherein the suspending agent is xanthan gum.
Claim 43
Dependent Claim
11 words
A method of claim 24 further comprising an osmotically active material.
Claim 44
Dependent Claim
63 words
A method of claim 41 wherein the osmotically active material is selected from the group consisting of erythrose, threose, ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, idose, galactose, talose, ribulose, fructose, sorbitol, mannitol, sedoheptulose, lactose, sucrose, maltose, cellubiose, glycine, serine, threonine, cysteine, tyrosine, asparagine, glutamine, aspartic acid, glutamic acid, lysine, arginine, histidine, propylene glycol, polypropylene glycol, ethylene glycol, polyethylene glycol and polyvinylpyrrolidone.
Claim 45
Dependent Claim
12 words
A method of claim 42 wherein the osmotically active material is glycine.
Claim 46
Dependent Claim
23 words
A method of claim 24 further comprising a pH regulating additive effective to maintain a pH of between about 3 and about 10.
Claim 47
Dependent Claim
22 words
A method of claim 44 wherein the pH regulating additive is effective to maintain a pH of between about 3 and 8.
Claim 48
Dependent Claim
31 words
A method of claim 24 further comprising a suspending agent, an osmotically active material, and a pH regulating additive effective to maintain a pH of between about 3 and about 10.
Claim 49
Independent Claim
76 words
A method for diagnosing the presence of diseased tissue in a patient comprising (i) administering to the patient a diagnostically effective amount of a contrast medium comprising an aqueous solution or suspension of a biocompatible non-cross-linked synthetic polymer in admixture with a contrast agent, wherein the contrast medium is hypoosmotic to bodily fluids of the patient, and (ii) scanning the patient using magnetic resonance imaging to obtain visible images of any diseased tissue in the patient.
Claim 50
Independent Claim
76 words
A method for diagnosing the presence of diseased tissue in a patient comprising (i) administering to the patient a diagnostically effective amount of a contrast medium comprising an aqueous solution or suspension of a biocompatible non-cross-linked synthetic polymer in admixture with a contrast agent, wherein the contrast medium is hypoosmotic to bodily fluids of the patient, and (ii) scanning the patient using magnetic resonance imaging to obtain visible images of any diseased tissue in the patient.
Claim 51
Dependent Claim
16 words
A method of claim 47 wherein the scanning is of the gastrointestinal region of the patient.
Claim 52
Dependent Claim
15 words
A method of claim 47 wherein the scanning is of the vasculature of the patient.
Claim 53
Dependent Claim
18 words
A method of claim 47 wherein said hypoosmotic contrast medium has an osmolarity of less than 280 milliosmoles/liter.
Claim 54
Dependent Claim
16 words
A method of claim 50 wherein said osmolarity is between about 200 and about 270 milliosmoles/liter.
Claim 55
Dependent Claim
16 words
A method of claim 51 wherein said osmolarity is between about 220 and about 260 milliosmoles/liter.
Claim 56
Dependent Claim
16 words
A method of claim 52 wherein said osmolarity is between about 250 and about 260 milliosmoles/liter.
Claim 57
Dependent Claim
18 words
A method of claim 47 wherein the polymer has a weight average molecular weight of less than 30,000.
Claim 58
Dependent Claim
25 words
A method of claim 47 wherein the polymer is selected from the group consisting of polyethylenes, polyoxyethylenes, polypropylenes, pluronic acids, pluronic alcohols, polyvinyls, and polyvinylpyrrolidones.
Claim 59
Dependent Claim
11 words
A method of claim 24 wherein the polymer is polygalacturonic acid.
Claim 60
Dependent Claim
23 words
A method of claim 24 wherein the contrast agent is selected from the group consisting of paramagnetic, superparamagnetic and proton density contrast agents.
Claim 61
Dependent Claim
22 words
A method of claim 57 wherein the contrast agent is a paramagnetic contrast agent which is a transition, lanthanide or actinide element.
Claim 62
Dependent Claim
29 words
A method of claim 58 wherein the paramagnetic contrast agent is selected from the group consisting of Gd(III), Mn(II), Cu(II), Cr(III), Fe(II), Fe(III), Co(II), Er(II), Ni(II), Eu(III) and Dy(III).
Claim 63
Dependent Claim
12 words
A method of claim 59 wherein the paramagnetic contrast agent is Mn(II).
Claim 64
Dependent Claim
10 words
A method of claim 47 further comprising a suspending agent.
Claim 65
Dependent Claim
73 words
A method of claim 61 wherein the suspending agent is selected from the group consisting of xanthum gum, acacia, agar, alginic acid, aluminum monostearate, bassorin, karaya, gum arabic, unpurified bentonite, purified bentonite, bentonite magma, calcium carboxymethylcellulose, sodium carboxymethylcellulose, carrageenan, microcrystalline cellulose, dextran, gelatin, guar gum, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, magnesium aluminum silicate, methylcellulose, pectin, casein, gelatin, polyethylene oxide, polyvinyl alcohol, povidone, propylene glycol, alginate, silicon dioxide, silicon dioxide colloidal, alginate, sodium alginate, and tragacanth.
Claim 66
Dependent Claim
12 words
A method of claim 62 wherein the suspending agent is xanthan gum.
Claim 67
Dependent Claim
11 words
A method of claim 47 further comprising an osmotically active material.
Claim 68
Dependent Claim
63 words
A method of claim 64 wherein the osmotically active material is selected from the group consisting of erythrose, threose, ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, idose, galactose, talose, ribulose, fructose, sorbitol, mannitol, sedoheptulose, lactose, sucrose, maltose, cellobiose, glycine, serine, threonine, cysteine, tyrosine, asparagine, glutamine, aspartic acid, glutamic ,acid, lysine, arginine, histidine, propylene glycol, polypropylene glycol, ethylene glycol, polyethylene glycol and polyvinylpyrrolidone.
Claim 69
Dependent Claim
12 words
A method of claim 65 wherein the osmotically active material is glycine.
Claim 70
Dependent Claim
23 words
A method of claim 47 further comprising a pH regulating additive effective to maintain a pH of between about 3 and about 10.
Claim 71
Dependent Claim
22 words
A method of claim 67 wherein the pH regulating additive is effective to maintain a pH of between about 3 and 8.
Claim 72
Dependent Claim
31 words
A method of claim 47 further comprising a suspending agent, an osmotically active material, and a pH regulating additive effective to maintain a pH of between about 3 and about 10.
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