US4830849A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
Assignee: Thomas Jefferson University
•
Filing: 1988-04-14
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Granted: 1989-05-16
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Expires: 2008-04-14
Abstract
Abstract A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the crebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.
Inventors
- 👤 Jewell L. Osterholm
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 20:04
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61B; A61B10/00; A61B10/0045; A61K31/00; A61K31/02; A61K9/0029; A61B2010/0077; A61M; A61M25/00; A61M25/01; A61M25/02; A61M2025/028; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/36; A61M2205/3653; Y; Y10; Y10T; Y10T436/00; Y10T436/17; Y10T436/173845; Y10T436/20; Y10T436/200833; Y10T436/201666; Y10T436/204998
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
113 words
A method of making a diagnostic fluid useful for diagnosing conditions of central nervous system tissue of a mammal comprising: (a) providing an oxygenated physiologic synthetic spinal fluid of known composition; (b) injecting said synthetic spinal fluid into at least a first portion of the cerebrospinal pathway of a mammal; (c) withdrawing fluid comprising at least a portion of said synthetic spinal fluid from a second portion of said pathway, whereby said withdrawn fluid is said diagnostic fluid and is used for diagnosing conditions of the central nervous system tissue of said mammal by comparing the composition of said diagnostic fluid with that of said oxygenated physiologic synthetic spinal fluid prior to injection.
Claim 2
Independent Claim
113 words
A method of making a diagnostic fluid useful for diagnosing conditions of central nervous system tissue of a mammal comprising: (a) providing an oxygenated physiologic synthetic spinal fluid of known composition; (b) injecting said synthetic spinal fluid into at least a first portion of the cerebrospinal pathway of a mammal; (c) withdrawing fluid comprising at least a portion of said synthetic spinal fluid from a second portion of said pathway, whereby said withdrawn fluid is said diagnostic fluid and is used for diagnosing conditions of the central nervous system tissue of said mammal by comparing the composition of said diagnostic fluid with that of said oxygenated physiologic synthetic spinal fluid prior to injection.
Claim 3
Dependent Claim
12 words
The diagnostic fluid produced in accordance with the method of claim 1.
References Cited (Backward Citations)
US3482575A
Cited
US3516410A
Cited
US3583387A
Cited
US3626950A
Cited
US3669094A
Cited
US3669116A
Cited
US3690323A
Cited
US3818229A
Cited
DE2163191A1
Cited
FR2118977A1
Cited
GB1381879A
Cited
US3975512A
Cited
CA973094A
Cited
US3946731A
Cited
US3753865A
Cited
US3823091A
Cited
US3941119A
Cited
US3962439A
Cited
US3989843A
Cited
AU4127178A
Cited
US3894541A
Cited
US4073879A
Cited
US4163734A
Cited
US4070460A
Cited
US4009270A
Cited
US4148314A
Cited
US4173654A
Cited
US4173224A
Cited
US4110474A
Cited
AU4295478A
Cited
AU5451380A
Cited
AU6255580A
Cited
US4393863A
Cited
US4378797A
Cited
US4445886A
Cited
US4445514A
Cited
US4299728A
Cited
US4445887A
Cited
US4446155A
Cited
US4445500A
Cited
US4446154A
Cited
US4445888A
Cited
US4450841A
Cited
US4451251A
Cited
US4443480A
Cited
US4423077A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-15 | 1992-11-14 | 1993-05-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-15 | 1996-11-14 | 1997-05-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-15 | 2000-11-14 | 2001-05-16 | $7700.00 | Window Closed / Lapsed |