US4110474A
Expired / Lapsed
US
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Tetramethylpentane blood substitutes
Assignee: Cincinnati Children's Hospital Medical Center
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Filing: 1977-08-26
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Granted: 1978-08-29
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Expires: 1997-08-26
Abstract
Abstract Perfluorination of 2,2,4,4-tetramethylpentane by direct fluorination with F 2 or like reagents at low temperature, using inert gaseous diluents, yields a mixture of perfluoro 2,2,4,4-tetramethylpentane and 3-hydro-nona-decafluoro 2,2,4,4-tetramethylpentane together with lesser amounts of 3,3-dihydro-octadecafluoro 2,2,4,4-tetramethylpentane. The perfluoro and nonadecafluoro-tetramethylpentane mixture is useful in synthetic blood substitute compositions.
Inventors
- 👤 Richard J. Lagow
- 👤 Lawrence A. Shimp
- 👤 Leland C. Clark, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:03
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; C; C07; C07C; C07C17/00; C07C17/093; C07C17/10; C07C19/00; C07C19/08
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
23 words
An artificial blood comprising an emulsion of a mixture comprising perfluoro 2,2,4,4-tetramethylpentane and 3-hydro-nonadecafluro 2,2,4,4-tetramethylpentane in water, said emulsion containing a non-toxic emulsifier.
Claim 2
Dependent Claim
23 words
An artificial blood comprising an emulsion of a mixture comprising perfluoro 2,2,4,4-tetramethylpentane and 3-hydro-nonadecafluro 2,2,4,4-tetramethylpentane in water, said emulsion containing a non-toxic emulsifier.
Claim 3
Dependent Claim
21 words
The composition according to claim 1 wherein the amount of said fluorinated mixture is 10-30% by volume of the total emulsion.
Claim 4
Dependent Claim
25 words
The composition according to claim 1 which additionally contains 10-100 cc O 2 (25° C, 760 mm Hg) per 100 cc of said fluorinated mixture.
Claim 5
Dependent Claim
23 words
Composition according to claim 1 wherein the particle size of the fluorinated materials in the emulsion is from about 0.001 to 10 microns.
Claim 6
Dependent Claim
23 words
The composition according to claim 4 wherein about 50 weight percent of the particles have diameters of from about 0.05 to 0.3 microns.
Claim 7
Dependent Claim
17 words
The composition according to claim 1 wherein the amount of water is greater than 40% by volume.
Claim 8
Dependent Claim
23 words
A method for supporting oxygen-carbon dioxide transport in an animal body which comprises intravascular administration of an artificial blood defined in claim 1.
Claim 9
Dependent Claim
55 words
A method for supporting oxygen transfer in an animal organ which comprises externally perfusing the animal organ with an artificial blood defined in claim 1 having oxygen dissolved therein, the perfluorinated material in said blood having a vapor pressure which permits it to leave the organ without causing adverse gas collection in the organ tissue.
Claim 10
Dependent Claim
39 words
An artificial blood comprising an emulsion of a fluorinated material in water, said emulsion containing a nontoxic emulsifier and said fluorinated material being obtained by fluroination of 2,2,4,4-tetramethylpentane with BrF 3 in an inert gaseous diluent at elevated temperatures.
Claim 11
Dependent Claim
39 words
An artificial blood comprising an emulsion of a fluorinated material in water, said emulsion containing a nontoxic emulsifier and said fluorinated material being obtained by fluroination of 2,2,4,4-tetramethylpentane with BrF 3 in an inert gaseous diluent at elevated temperatures.
Claim 12
Dependent Claim
19 words
The composition according to claim 9 wherein the amount of said fluorinated mixture is 10-30% of the total emulsion.
Claim 13
Dependent Claim
25 words
The composition according to claim 9 which additionally contains 10-100 cc O 2 (25° C, 760 mm Hg) per 100 cc of said fluorinated mixture.
Claim 14
Dependent Claim
24 words
The composition according to claim 9 wherein the particle size of the fluorinated materials in the emulsion is from about 0.001 to 10 microns.
Claim 15
Dependent Claim
23 words
The composition according to claim 9 wherein about 50 weight percent of the particles have diameters of from about 0.05 to 0.3 microns.
Claim 16
Dependent Claim
17 words
The composition according to claim 9 wherein the amount of water is greater than 40% by volume.
Claim 17
Dependent Claim
23 words
A method for supporting oxygen-carbon dioxide transport in an animal body which comprises intravascular administration of an artificial blood defined in claim 9.
Claim 18
Dependent Claim
55 words
A method for supporting oxygen transfer in an animal organ which comprises externally perfusing the animal organ with an artificial blood defined in claim 9 having oxygen dissolved therein, the perfluorinated material in said blood having a vapor pressure which permits it to leave the organ without causing adverse gas collection in the organ tissue.
Claim 19
Dependent Claim
6 words
A mixture comprising perfluoro-2,2,4,4-tetramethylpentane and 3-hydro-nonadecafluro-2,2,4,4-tetramethylpentane.
Claim 20
Dependent Claim
6 words
A mixture comprising perfluoro-2,2,4,4-tetramethylpentane and 3-hydro-nonadecafluro-2,2,4,4-tetramethylpentane.
References Cited (Backward Citations)
US3823091A
Cited
US3989843A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-08-28 | 1982-02-27 | 1982-08-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-08-28 | 1986-02-27 | 1986-08-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-08-28 | 1990-02-27 | 1990-08-29 | $7700.00 | Window Closed / Lapsed |