US4443480A
Expired / Lapsed
US
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Artificial blood and other gas transport agents
Assignee: Cincinnati Children's Hospital Medical Center
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Filing: 1982-04-12
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Granted: 1984-04-17
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Expires: 2002-04-12
Abstract
Abstract Gas transport agents such as artificial blood containing a perfluorocyclocarbon and an amine oxide are disclosed. These compositions have been found to provide transparent emulsions or solutions for use in oxygen transport, particularly in animals. Large concentrations of perfluorocarbons may be employed even up to 50% or more by volume in preparing emulsions, microemulsions or solutions. The emulsions or solutions have been found to be very stable at room temperature storage conditions thereby providing significant advantages.
Inventors
- 👤 Leland C. Clark, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:40
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02; A61K31/025; A61K31/13; A61K31/16; A61P; A61P7/00; A61P7/08
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
13 words
A gas transport agent liquid composition containing a perfluorocyclocarbon and an organoamine oxide.
Claim 2
Dependent Claim
13 words
A gas transport agent liquid composition containing a perfluorocyclocarbon and an organoamine oxide.
Claim 3
Dependent Claim
12 words
The composition of claim 1 wherein said oxide is a fluoroorganoamine oxide.
Claim 4
Dependent Claim
12 words
The composition of claim 1 wherein said oxide is a polyfluoroamidoamine oxide.
Claim 5
Dependent Claim
14 words
The composition of claim 3 wherein the oxide is defined by the formula ##STR3##
Claim 6
Dependent Claim
31 words
The composition of claim 1 wherein the perfluorocyclocarbon is a perfluorinated compound selected from the group consisting of an adamantane, substituted adamantane, decalin, substituted decalin, bicyclononane, substituted bicyclononane, and mixtures thereof.
Claim 7
Dependent Claim
11 words
The composition of claim 1 wherein said perfluorocyclocarbon is a solid.
Claim 8
Dependent Claim
22 words
An oxygen transfer agent liquid composition comprising water, a major amount of a perfluorocyclocarbon, and a minor amount of an organoamine oxide.
Claim 9
Dependent Claim
22 words
An oxygen transfer agent liquid composition comprising water, a major amount of a perfluorocyclocarbon, and a minor amount of an organoamine oxide.
Claim 10
Dependent Claim
34 words
The composition of claim 6 wherein said perfluorocyclocarbon is contained in an amount of from about 10 to about 50% and said oxide is present in an amount of from about 1 to 10%.
Claim 11
Dependent Claim
13 words
The composition of claim 7 wherein said amine oxide is a polyfluoroorganoamine oxide.
Claim 12
Dependent Claim
13 words
The composition of claim 9 wherein said amine oxide is a polyfluoroamidoamine oxide.
Claim 13
Dependent Claim
33 words
The composition of claim 7 wherein the perfluorocyclocarbon is selected from a perfluorinated compound selected from the group consisting of an adamantane, substituted adamantane, decalin, substituted decalin, bicyclononane, substituted bicyclononane, and mixtures thereof.
Claim 14
Dependent Claim
29 words
The composition of claim 7 wherein said perfluorocyclocarbon is selected from the group consisting of perfluoro(methylcyclohexane), perfluoro(1,3-dimethylcyclohexane), perfluoro(decahydronaphthalene), perfluoro(decahydro-1-methylnaphthalene), perfluoro(decahydrodimethylnaphthalene), perfluorodimethyladamantane, perfluorotrimethylbicyclo[3.3.1.]nonane, perfluorotetrahydrodicyclopentadiene, perfluorobicyclo[5.3.0.]decane and perfluorodimethylbicyclo[3.3.1.]nonane, or mixtures thereof.
Claim 15
Dependent Claim
15 words
The composition of claim 7 wherein said perfluorocyclocarbon is a mixture of perfluorodimethyladamantane and perfluorotrimethylbicyclo[3.3.1.]nonane.
Claim 16
Dependent Claim
13 words
An artificial blood liquid composition comprising water, a perfluorocyclocarbon and an organoamine oxide.
Claim 17
Dependent Claim
13 words
An artificial blood liquid composition comprising water, a perfluorocyclocarbon and an organoamine oxide.
Claim 18
Dependent Claim
34 words
The composition of claim 14 wherein said perfluorocyclocarbon is contained in an amount of from about 10 to about 50% and said oxide is present in an amount of from about 1 to 10%.
Claim 19
Dependent Claim
13 words
The composition of claim 14 wherein said amine oxide is a polyfluoroorganoamine oxide.
Claim 20
Dependent Claim
13 words
The composition of claim 16 wherein said amine oxide is a polyfluoroamidoamine oxide.
Claim 21
Dependent Claim
33 words
The composition of claim 14 wherein the perfluorocyclocarbon is selected from a perfluorinated compound selected from the group consisting of an adamantane, substituted adamantane, decalin, substituted decalin, bicyclononane, substituted bicyclononane, and mixtures thereof.
Claim 22
Dependent Claim
29 words
The composition of claim 14 wherein said perfluorocyclocarbon is selected from the group consisting of perfluoro(methylcyclohexane), perfluoro(1,3-dimethylcyclohexane), perfluoro(decahydronaphthalene), perfluoro(decahydro-1-methylnaphthalene), perfluoro(decahydrodimethylnaphthalene), perfluorodimethyladamantane, perfluorotrimethylbicyclo[3.3.1.]nonane, perfluorotetrahydrodicyclopentadiene, perfluorobicyclo[5.3.0.]decane and perfluorodimethylbicyclo[3.3.1.]nonane, or mixtures thereof.
Claim 23
Dependent Claim
15 words
The composition of claim 14 wherein said perfluorocyclocarbon is a mixture of perfluorodimethyladamantane and perfluorotrimethylbicyclo[3.3.1.]nonane.
Claim 24
Dependent Claim
27 words
A room temperature stable artificial blood liquid composition comprising an aqueous mixture containing a major amount of a perfluorocyclocarbon and a minor amount of an organoamine oxide.
Claim 25
Dependent Claim
27 words
A room temperature stable artificial blood liquid composition comprising an aqueous mixture containing a major amount of a perfluorocyclocarbon and a minor amount of an organoamine oxide.
Claim 26
Dependent Claim
34 words
The composition of claim 21 wherein said perfluorocyclocarbon is contained in an amount of from about 10 to about 50% and said oxide is present in an amount of from about 1 to 10%.
Claim 27
Dependent Claim
13 words
The composition of claim 21 wherein said amine oxide is a polyfluoroorganoamine oxide.
Claim 28
Dependent Claim
15 words
The composition of claim 23 wherein said amine oxide is defined by the formula ##STR4##
Claim 29
Dependent Claim
29 words
The composition of claim 21 wherein said perfluorocyclocarbon is selected from the group consisting of perfluoro(methylcyclohexane), perfluoro(1,3-dimethylcyclohexane), perfluoro(decahydronaphthalene), perfluoro(decahydro-1-methylnaphthalene), perfluoro(decahydrodimethylnaphthalene), perfluorodimethyladamantane, perfluorotrimethylbicyclo[3.3.1.]nonane, perfluorotetrahydrodicyclopentadiene, perfluorobicyclo[5.3.0.]decane and perfluorodimethylbicyclo[3.3.1]nonane, or mixtures thereof.
Claim 30
Dependent Claim
15 words
The composition of claim 21 wherein said perfluorocyclocarbon is a mixture of perfluorodimethyladamantane and perfluorotrimethylbicyclo[3.3.1.]nonane.
Claim 31
Dependent Claim
32 words
A room temperature stable artificial blood liquid composition comprising an aqueous mixture containing, a major amount of a perfluorocyclocarbon mixture of perfluorodimethyladamantane and perfluorotrimethylbicyclo[3.3.1.]nonane and a minor amount of a fluoroorganoamine oxide.
Claim 32
Dependent Claim
32 words
A room temperature stable artificial blood liquid composition comprising an aqueous mixture containing, a major amount of a perfluorocyclocarbon mixture of perfluorodimethyladamantane and perfluorotrimethylbicyclo[3.3.1.]nonane and a minor amount of a fluoroorganoamine oxide.
Claim 33
Dependent Claim
13 words
The composition of claim 27 wherein said amine oxide is a polyfluoroamidoamine oxide.
Claim 34
Dependent Claim
13 words
The composition of claim 28 wherein said oxide defined by the formula ##STR5##
Claim 35
Dependent Claim
41 words
The composition of claim 29 wherein the perfluorocyclocarbon mixture is contained in an amount of from about 10 to about 50% and the oxide is contained in an amount of from about 1 to 10% to obtain a substantially transparent liquid.
References Cited (Backward Citations)
US3194840A
Cited
US3600415A
Cited
US3828085A
Cited
US3778381A
Cited
US3911138A
Cited
US3911138B1
Cited
US4105798A
Cited
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