US3962439A
Expired / Lapsed
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Oxygen-transferable emulsion
Assignee: Tanabe Pharma Corp
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Filing: 1974-02-04
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Granted: 1976-06-08
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Expires: 1994-02-04
Abstract
Abstract Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C3-5-alkylcyclohexanes), perfluoro(C4-6-alkyl tetrahydropyrans), perfluoro(C5-7-alkyltetrahydrofurans), perfluoro(C5-7-alkylmorpholins) and perfluoro(C9-11-trialkylamines) are emulsified in a physiologically acceptable aqueons solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 mu . It is usable as a blood substitute or a perfusate for preservation of the internal organs.
Inventors
- 👤 Kazumasa Yokoyama
- 👤 Koichi Yamanouchi
- 👤 Ryoichiro Murashima
- 👤 Ryozo Watanabe
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 00:13
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K31/00; A61K31/02
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
160 words
A stable emulsion in a physiologically acceptable aqueous medium of an oxygen-transferable saturated perfluorocarbon compound having 9 to 11 carbon atoms and a particle size of about 0.05 to about 0.3 μ, which comprises said perfluorocarbon compound, a phospholipid as emulsifier, and at least one fatty acid compound as emulsifying adjuvant selected from the group consisting of fatty acids having 8 to 22 carbon atoms, physiologically acceptable salts and monoglycerides thereof, the perfluorocarbon compound being at least one member selected from the group consisting of perfluoro alkylcyclohexane having 3 to 5 carbon atoms in the alkyl, perfluorodecalin, perfluoro methyldecalin, perfluoro alkyltetrahydropyran having 4 to 6 carbon atoms in the alkyl, perfluoro alkyltetrahydrofuran having 5 to 7 carbon atoms in the alkyl, perfluoro alkylpiperidine having 4 to 6 carbon atoms in the alkyl, perfluoro alkylmorpholine having 5 to 7 carbon atoms in the alkyl, perfluoro trialkylamine, perfluoro (diethylcyclohexylamine), or perfluoro (dioxaalkane), said emulsion being suitable for use as a blood substitute.
Claim 2
Dependent Claim
160 words
A stable emulsion in a physiologically acceptable aqueous medium of an oxygen-transferable saturated perfluorocarbon compound having 9 to 11 carbon atoms and a particle size of about 0.05 to about 0.3 μ, which comprises said perfluorocarbon compound, a phospholipid as emulsifier, and at least one fatty acid compound as emulsifying adjuvant selected from the group consisting of fatty acids having 8 to 22 carbon atoms, physiologically acceptable salts and monoglycerides thereof, the perfluorocarbon compound being at least one member selected from the group consisting of perfluoro alkylcyclohexane having 3 to 5 carbon atoms in the alkyl, perfluorodecalin, perfluoro methyldecalin, perfluoro alkyltetrahydropyran having 4 to 6 carbon atoms in the alkyl, perfluoro alkyltetrahydrofuran having 5 to 7 carbon atoms in the alkyl, perfluoro alkylpiperidine having 4 to 6 carbon atoms in the alkyl, perfluoro alkylmorpholine having 5 to 7 carbon atoms in the alkyl, perfluoro trialkylamine, perfluoro (diethylcyclohexylamine), or perfluoro (dioxaalkane), said emulsion being suitable for use as a blood substitute.
Claim 3
Dependent Claim
26 words
The emulsion according to claim 1 wherein the perfluorocarbon compound is perfluoro alkylcyclohexane having 3 to 5 carbon atoms in the alkyl, perfluorodecalin or perfluoro methyldecalin.
Claim 4
Dependent Claim
54 words
The emulsion according to claim 1 wherein the perfluorocarbon compound is perfluoro alkyltetrahydropyran having 4 to 6 carbon atoms in the alkyl, perfluoro alkyltetrahydrofuran having 5 to 7 carbon atoms in the alkyl, alkylpiperidine having 4 to 6 carbon atoms in the alkyl, or perfluoro alkylmorpholine having 5 to 7 carbon in the alkyl.
Claim 5
Dependent Claim
14 words
The emulsion according to claim 1, wherein the perfluorocycloalkane is perfluorodecalin or perfluoro (methyldecalin).
Claim 6
Dependent Claim
16 words
The emulsion according to claim 2, wherein the perfluorocycloalkane is perfluoro(butylcyclohexane), perfluoro(methylpropylcyclohexane), perfluoro(trimethylcyclohexane), perfluoro(ethylpropylcyclohexane) or perfluoro(pentylcyclohexane).
Claim 7
Dependent Claim
22 words
The emulsion according to claim 3, wherein the perfluoro-saturated-heterocyclic compound is perfluoro(butyltetrahydropyran), perfluoro(pentyltetrahydrofuran), perfluoro(hexyltetrahydrofuran), perfluoro(heptyltetrahydrofuran), perfluoro(N-hexylpiperidine), perfluoro(N-butylpiperidine), perfluoro (N-pentylmorpholine), perfluoro(N-hexylmorpholine) or perfluoro(N-heptylmorpholine).
Claim 8
Dependent Claim
18 words
The emulsion according to claim 1, wherein the perfluorocarbon compound is a perfluoro trialkylamine, perfluoro (diethylcyclohexylamine) or perfluoro(dioxa-alkane).
Claim 9
Dependent Claim
19 words
The emulsion according to claim 7, wherein the perfluorocarbon compound is a perfluoro-tert-amine which is perfluoro(diethylhexylamine), perfluoro(dipropylbutylamine) or perfluoro(diethylcyclohexylamine).
Claim 10
Dependent Claim
33 words
The emulsion according to claim 7, wherein the perfluorocarbon compound is a perfluoro(dioxa-alkane) which is perfluoro(tetramethylene glycol diisoproyl ether), perfluoro (trimethylene glycol diisopropyl ether) perfluoro(trimethylene glycol diisobutyl ether) or perfluoro(isopropylidene glycol di-n-propyl ether).
Claim 11
Dependent Claim
16 words
The emulsion according to claim 1, wherein the physiologically acceptable aqueous medium is an isotonic solution.
Claim 12
Dependent Claim
17 words
The emulsion according to clain 10, wherein the isotonic solution is 2.5% by weight aqueous glycerin solution.
Claim 13
Dependent Claim
17 words
The emulsion according to clain 10, wherein the isotonic solution is 2.5% by weight aqueous glycerin solution.
Claim 14
Dependent Claim
39 words
The emulsion according to claim 1, wherein the amount of the perfluorocarbon compound is 10 to 40% (W/V), that of the phospholipid is 2 to 6% (W/V) and that of the fatty acid compound is 0.001 to 0.1% (W/V).
Claim 15
Dependent Claim
35 words
The emulsion according to claim 1, wherein the fatty acid compound is caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, palmitoleic acid, oleic acid, linoleic acid or arachidonic acid.
Claim 16
Dependent Claim
44 words
The emulsion according to claim 1, wherein the fatty acid is an alkali metal salt of a fatty acid selected from caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, palmitoleic acid, oleic acid, linoleic acid and arachidonic acid.
Claim 17
Dependent Claim
18 words
The emulsion according to claim 14, wherein the alkali metal salt of the fatty acid is potassium palmitate.
Claim 18
Dependent Claim
18 words
The emulsion according to claim 14, wherein the alkali metal salt of the fatty acid is sodium oleate.
Claim 19
Dependent Claim
42 words
The emulsion according to claim 1, wherein the fatty acid compound is monoglyceride of a fatty acid selected from caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, palmitoleic acid, oleic acid, linoleic acid and arachidonic acid.
Claim 20
Dependent Claim
16 words
The emulsion according to claim 1, wherein the phospholipid is egg yolk phospholipid or soybean phospholipid.
Claim 21
Dependent Claim
48 words
The emulsion, according to claim 1 wherein the phospholipid is egg yolk phospholipid or soybean phospholipid, the amount of perfluorocarbon compound is 10 to 40% (W/V), the amount of phospholipid is 2 to 6% (W/V) and the amount of the fatty acid compounds is 0.001 to 0.1% (W/V).
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-08 | 1979-12-08 | 1980-06-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-08 | 1983-12-08 | 1984-06-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-08 | 1987-12-08 | 1988-06-08 | $7700.00 | Window Closed / Lapsed |