US4423077A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Perfluorochemical emulsion artificial blood
Assignee: University of Pennsylvania
•
Filing: 1982-07-27
•
Granted: 1983-12-27
•
Expires: 2002-07-27
Abstract
Abstract Particles of perfluoro compound with a lipid coating are emulsified in aqueous medium, wherein the proportion of perfluoro compound in the emulsion is preferably about 30-75% (w/v) and the proportion of lipid is preferably about 7-9% (w/v). In the resulting stable emulsion 95% of these particles having diameters less than 0.2μ. The emulsion is useful as an artificial blood for transport and delivery of oxygen to body tissues.
Inventors
- 👤 Henry A. Sloviter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:36
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61P; A61P7/00; A61P7/08
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
33 words
A stable emulsion of perfluoro compound particles comprising about 30-75% (w/v) perfluoro compound, about 7-9% (w/v) of a non antigenic lipid which coats the perfluoro compound particles, and a physiologically acceptable aqueous medium.
Claim 2
Dependent Claim
33 words
A stable emulsion of perfluoro compound particles comprising about 30-75% (w/v) perfluoro compound, about 7-9% (w/v) of a non antigenic lipid which coats the perfluoro compound particles, and a physiologically acceptable aqueous medium.
Claim 3
Dependent Claim
19 words
An emulsion according to claim 1 containing an emulsifier different from the substance which coats the perfluoro compound particles.
Claim 4
Dependent Claim
22 words
An emulsion according to claim 1 wherein the perfluoro compound is selected from the group consisting of perfluorodecalin, perfluoromethyldecalin, perfluorotripropylamine, and perfluorotributylamine.
Claim 5
Dependent Claim
12 words
An emulsion according to claim 1 wherein the lipid is a phospholipid.
Claim 6
Dependent Claim
11 words
An emulsion according to claim 4 wherein the phospolipid is lecithin.
Claim 7
Dependent Claim
32 words
An emulsion according to claim 5 comprising about 67-76% (w/v) of a perfluoro compound selected from the group consisting of perfluorodecalin and perfluorotripropylamine, about 7-9% (w/v) lecithin, and a physiologically acceptable medium.
Claim 8
Dependent Claim
26 words
An emulsion according to claim 6 containing stable emulsion particles of about 0.1μ average diameter, about 95% of said particles having a diameter less than 0.2μ.
Claim 9
Dependent Claim
14 words
An emulsion according to claim 6 wherein the physiologically acceptable medium is Tyrode solution.
Claim 10
Dependent Claim
61 words
An emulsion according to claim 6 at a pH of between about 7.2 and 7.6 wherein the physiologically acceptable medium comprises an aqueous solution of the following: about 0.75% (w/v) KCl, about 0.02% (w/v) CaCl 2 , about 0.007% (w/v) MgCl 2 , about 0.004% (w/v) NaH 2 PO 4 , about 0.07% (w/v) NaHCO 3 , about 0.07% (w/v) glucose.
Claim 11
Dependent Claim
24 words
An emulsion according to claim 6 which is autoclavable by conventional autoclave procedures at about 122° C.-127° C. and about 15 lb/in 2 pressure.
Claim 12
Dependent Claim
28 words
An emulsion according to claim 6 wherein the perfluoro compound particles are coated with adherent lecithin in the amount of about 50-70 μmols per ml of perfluoro compound.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-26 | 1987-06-27 | 1987-12-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-26 | 1991-06-27 | 1991-12-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-26 | 1995-06-27 | 1995-12-27 | $7700.00 | Window Closed / Lapsed |