US4299728A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Blood gas control
Assignee: IL Holding Spa
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Filing: 1980-07-21
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Granted: 1981-11-10
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Expires: 2000-07-21
Abstract
Abstract A blood gas control liquid comprises water, 5-40 percent by volume of a water-insoluble perfluorinated compound material that has an oxygen solubility coefficient, at one atmosphere pressure, 25 DEG C., and a volumetric proportion of 15 percent of at least 10 ml O2 per 100 mL emulsion, 0.25-10 percent by volume of a nonionic, fluorocarbon-based surfactant, a preservative agent and a buffering agent which is substantially non-reactive with said preservative agent. The blood gas control liquid has a pH in the range of 7-8, a partial pressure of carbon dioxide in the range of 15-80 millimeters Hg, and a partial pressure of oxygen in the range of 20-600 mm Hg.
Inventors
- 👤 Alan D. Cormier
- 👤 Marvin Feil
- 👤 Kenneth D. Legg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:16
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; G01N2496/00; G01N2496/70; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/102499
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
158 words
A blood gas control product comprising a sealed container and a liquid composition of matter in said container, said composition of matter comprising water, 5-40% by volume of a water-insoluble perfluorinated compound material, said perfluorinated compound material having an oxygen solubility coefficient, at one atmosphere pressure, 25° C., and a volumetric proportion of 15%, of at least 10 ml O 2 per 100 ml liquid, 0.25-10% by volume of a non-ionic fluorocarbon-based surfactant capable of emulsifying said perfluorinated compound material, a preservative present in a concentration sufficient to inhibit microbial growth in said blood gas control liquid without impairing the quality control functions of said liquid, and a pH buffering agent substantially non-reactive with said preservative, said blood gas control liquid having a pH in the range of 7.0 to 8.0, a partial pressure of CO 2 in the range of 15-80 mm Hg, and a partial pressure of O 2 in the range of 20-600 mm Hg.
Claim 2
Dependent Claim
158 words
A blood gas control product comprising a sealed container and a liquid composition of matter in said container, said composition of matter comprising water, 5-40% by volume of a water-insoluble perfluorinated compound material, said perfluorinated compound material having an oxygen solubility coefficient, at one atmosphere pressure, 25° C., and a volumetric proportion of 15%, of at least 10 ml O 2 per 100 ml liquid, 0.25-10% by volume of a non-ionic fluorocarbon-based surfactant capable of emulsifying said perfluorinated compound material, a preservative present in a concentration sufficient to inhibit microbial growth in said blood gas control liquid without impairing the quality control functions of said liquid, and a pH buffering agent substantially non-reactive with said preservative, said blood gas control liquid having a pH in the range of 7.0 to 8.0, a partial pressure of CO 2 in the range of 15-80 mm Hg, and a partial pressure of O 2 in the range of 20-600 mm Hg.
Claim 3
Dependent Claim
22 words
The blood gas control product of claim 1 wherein said preservative is an aldehyde, and said buffering agent includes a tertiary amine.
Claim 4
Dependent Claim
19 words
The blood gas control product of claim 2 wherein said aldehyde is formaldehyde, and said tertiary amine is HEPES.
Claim 5
Dependent Claim
27 words
The product of claim 1 wherein said composition further includes a coloring agent selected from the class consisting of Yellow #5 and Amarath, and a mixture thereof.
Claim 6
Dependent Claim
15 words
The product of claim 1 wherein the viscosity of said composition is comparable to blood.
Claim 7
Dependent Claim
72 words
The product of claim 1 wherein said composition contains less than 25% by volume of said compound material, less than 5% by volume of said surfactant, said preservative includes an aldehyde, said buffering agent includes a tertiary amine, and partial pressure of oxygen in the range of 50-80 mm Hg, and said composition further includes a coloring agent selected from the class consisting of Yellow #5 and Amarath, and a mixture thereof.
Claim 8
Dependent Claim
28 words
The blood gas control product of claim 3, wherein said compound material comprises a mixture of perfluoroalkanes, perfluorocyclic ethers, and perfluorotributylamine, and said non-ionic fluorocarbon-based surfactant comprises fluoroalkylpoly(ethyleneoxy)ethanols.
Claim 9
Dependent Claim
45 words
The blood gas control product of claim 3, wherein said compound material comprises a mixture of perfluoroalkanes and perfluorocyclic ethers, and said non-ionic fluorocarbon-based surfactant comprises a polymer of about 20-25 units of polyethylene oxide with between one and four tetrafluoroethylene groups at each end.
Claim 10
Dependent Claim
65 words
The blood gas control product of claim 7 wherein said perfluoroalkanes and perfluorocyclic ethers togehter comprise about 15% by volume of said liquid, said perfluorotributyl amine comprises about 5% by volume of said liquid, said fluoroalkylpoly(etheleneoxy)ethanol comprises about 2% by volume of said liquid, said preservative is formaldehyde present in a concentration of about 53 mM, and said product further comprises at least one dye.
Claim 11
Dependent Claim
56 words
The blood gas control product of claim 8 wherein said perfluoroalkanes and perfluorocyclic ethers together comprise about 20% of said liquid, said non-ionic polymeric, fluorocarbon-based surfactant comprises about 2% of said liquid by volume, and said preservative is formaldehyde present in a concentration of about 53 mM, and said product further comprises at least one dye.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-09 | 1985-05-11 | 1985-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-09 | 1989-05-11 | 1989-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-09 | 1993-05-11 | 1993-11-10 | $7700.00 | Window Closed / Lapsed |