US4378797A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
Assignee: Thomas Jefferson University
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Filing: 1980-04-14
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Granted: 1983-04-05
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Expires: 2000-04-14
Abstract
Abstract A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.
Inventors
- 👤 Jewell L. Osterholm
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:40
CPC Classifications
A; A61; A61M; A61M3/00; A61M3/02; A61K; A61K31/00; A61K31/02; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; A61K9/0029; A61P; A61P7/00; A61P9/00; A61P9/10; A61M2202/00; A61M2202/04; A61M2202/0468; A61M2202/0476; A61M2205/00; A61M2205/36; A61M2205/3653
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
79 words
An apparatus for treating hypoxic-ischemic neurologic tissue, comprising: (a) a reservoir containing synthetic oxygenatable nutrient liquid for treating hypoxic-ischemic neurologic tissue; (b) oxygenator means for oxygenating said liquid, to produce an oxygenated liquid; (c) cerebrospinal injection means for injecting said oxygenated liquid into an extra-vascular cerebrospinal body pathway; and (d) cerebrospinal withdrawal means for withdrawing fluid from said extra-vascular cerebrospinal pathway to create, in combination with said injection means, a circulation of said oxygenated liquid within said cerebrospinal pathway.
Claim 2
Independent Claim
79 words
An apparatus for treating hypoxic-ischemic neurologic tissue, comprising: (a) a reservoir containing synthetic oxygenatable nutrient liquid for treating hypoxic-ischemic neurologic tissue; (b) oxygenator means for oxygenating said liquid, to produce an oxygenated liquid; (c) cerebrospinal injection means for injecting said oxygenated liquid into an extra-vascular cerebrospinal body pathway; and (d) cerebrospinal withdrawal means for withdrawing fluid from said extra-vascular cerebrospinal pathway to create, in combination with said injection means, a circulation of said oxygenated liquid within said cerebrospinal pathway.
Claim 3
Dependent Claim
28 words
The invention of claim 1 wherein said injection means further comprises a cerebral catheter means for insertion into at least a brain ventricle for injection of liquid therein.
Claim 4
Dependent Claim
18 words
The invention of claim 1 wherein said withdrawal means comprises means for withdrawing liquid from the cisterna magna.
Claim 5
Dependent Claim
20 words
The invention of claim 1 further comprising monitoring means for monitoring the flow rate of said oxygenated liquid being injected.
Claim 6
Dependent Claim
21 words
The invention of claim 1 wherein said apparatus further comprises output analysis means for monitoring the characteristics of said (withdrawn) fluid.
Claim 7
Dependent Claim
11 words
The invention of claim 5 wherein said characteristics are physical characteristics.
Claim 8
Dependent Claim
29 words
The invention of claim 6 wherein said physical characteristics include at least one characteristic selected from the group consisting of: osmolarity; vapor pressure; temperature; viscosity; flow rate; or pressure.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-04-04 | 1986-10-04 | 1987-04-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-04-04 | 1990-10-04 | 1991-04-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-04-04 | 1994-10-04 | 1995-04-05 | $7700.00 | Window Closed / Lapsed |