US4838274A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Perfluoro-crown ethers in fluorine magnetic resonance imaging
Assignee: University of Pennsylvania
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Filing: 1987-09-18
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Granted: 1989-06-13
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Expires: 2007-09-18
Abstract
Abstract A method is disclosed for nuclear magnetic resonance imaging wherein the improvement is the use of perfluoro 15-crown-5 ether which has 20 magnetically similar fluorine atoms providing a superior signal to noise ratio with resultant enhanced diagnostic resolution.
Inventors
- 👤 Frank K. Schweighardt
- 👤 Joseph A. Rubertone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 06:08
CPC Classifications
A; A61; A61B; A61B6/00; A61K; A61K49/00; A61K49/06; Y; Y10; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
58 words
In a method for obtaining fluorine magnetic resonance images of body organs or tissues by adminstering to a mammal a fluorine-containing agent in a sufficient amount to provide fluorine magnetic resonance images of said organs or tissues and imaging said organs and tissues, the improvement comprising using as said fluorine-agent an aqueous isotonic emulsion of perfluoro 15-crown-5 ether.
Claim 2
Dependent Claim
58 words
In a method for obtaining fluorine magnetic resonance images of body organs or tissues by adminstering to a mammal a fluorine-containing agent in a sufficient amount to provide fluorine magnetic resonance images of said organs or tissues and imaging said organs and tissues, the improvement comprising using as said fluorine-agent an aqueous isotonic emulsion of perfluoro 15-crown-5 ether.
Claim 3
Dependent Claim
25 words
The method of claim 1 wherein the concentration of the emulsion is in the range of 5 to 25 wt% of the perfluoro 15-crown-5 ether.
Claim 4
Dependent Claim
19 words
The method of claim 1 wherein said fluorine-containing agent is administered to the cerebrospinal fluid compartment of a mammal.
Claim 5
Dependent Claim
60 words
The method of claim 1 wherein the fluorine-containing agent is administed by a process selected from the group consisting of direct injection into a body part, direct injection into a body cavity (thoracic, peritoneal), direct injection into a body compartent (CSF), direct injection into a space (subarachnoid), direct injection into a joint capsule, direct injection into the bloodstream or inhalation.
Claim 6
Dependent Claim
27 words
The method of claim 1 wherein after administration of the agent to the mammal, the desired tissue is biopsied and the biopsied and extracted tissue is imaged.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein the imaging is spinal cisternography.
Claim 8
Dependent Claim
11 words
The method of claim 1 wherein the imaging is cerebral cisternography.
Claim 9
Independent Claim
54 words
A method of cisternography for obtaining fluorine magnetic resonance images of cerebrospinal structures of brain tissues by direct injection into a mammalian cerebrospinal fluid compartment of an aqueous biocompatible isotonic emulsion of perfluoro 15-crown-5 ether in a sufficient amount to provide fluorine magnetic resonance images of said cerebrospinal structures and imaging said cerebrospinal structures.
Claim 10
Independent Claim
54 words
A method of cisternography for obtaining fluorine magnetic resonance images of cerebrospinal structures of brain tissues by direct injection into a mammalian cerebrospinal fluid compartment of an aqueous biocompatible isotonic emulsion of perfluoro 15-crown-5 ether in a sufficient amount to provide fluorine magnetic resonance images of said cerebrospinal structures and imaging said cerebrospinal structures.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-06-12 | 1992-12-12 | 1993-06-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-06-12 | 1996-12-12 | 1997-06-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-06-12 | 2000-12-12 | 2001-06-13 | $7700.00 | Window Closed / Lapsed |