US4612185A
Expired / Lapsed
US
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Methods and compositions for enhancing magnetic resonance imaging
Assignee: Mallinckrodt Inc
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Filing: 1984-10-15
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Granted: 1986-09-16
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Expires: 2004-10-15
Abstract
Abstract Water soluble, substantially nontoxic salts of compounds of the formula: <IMAGE> wherein n=1 to 5, are useful as fluorine magnetic resonance imaging agents for enhancing images of body organs and tissues. An illustrative salt of such compounds is sodium [2-(trifluoromethyl)benzamido]acetate.
Inventors
- 👤 Richard T. Dean
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:40
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/54; G01R33/56; G01R33/5601; A; A61; A61K; A61K49/00; A61K49/06
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
33 words
A composition for enhancing fluorine-19 magnetic resonance images of body organs and tissues, the composition comprising a water soluble, substantially nontoxic salt of a compound of the formula: ##STR4## wherein n=1 to 5.
Claim 2
Dependent Claim
33 words
A composition for enhancing fluorine-19 magnetic resonance images of body organs and tissues, the composition comprising a water soluble, substantially nontoxic salt of a compound of the formula: ##STR4## wherein n=1 to 5.
Claim 3
Dependent Claim
20 words
A composition as set forth in claim 1 wherein said salt is a sodium or N-methylglucamine salt of said compound.
Claim 4
Dependent Claim
14 words
A composition as set forth in claim 1 wherein said compound is 2-(trifluoromethyl)benzamidoacetic acid.
Claim 5
Dependent Claim
2 words
Sodium [2-(trifluoromethyl)benzamido]acetate.
Claim 6
Dependent Claim
2 words
Sodium [2-(trifluoromethyl)benzamido]acetate.
Claim 7
Independent Claim
56 words
A method for enhancing fluorine-19 magnetic resonance images of body organs and tissues which comprises administering to a mammal a composition comprising a water soluble, substantially nontoxic salt of a compound of the formula: ##STR5## wherein n=1 to 5, in a sufficient amount to provide enhancement of magnetic resonance images of said body organs and tissues.
Claim 8
Independent Claim
56 words
A method for enhancing fluorine-19 magnetic resonance images of body organs and tissues which comprises administering to a mammal a composition comprising a water soluble, substantially nontoxic salt of a compound of the formula: ##STR5## wherein n=1 to 5, in a sufficient amount to provide enhancement of magnetic resonance images of said body organs and tissues.
Claim 9
Dependent Claim
20 words
A method as set forth in claim 5 wherein said salt is a sodium or N-methylglucamine salt of said compound.
Claim 10
Dependent Claim
14 words
A method as set forth in claim 5 wherein said compound is 2-(trifluoromethyl)benzamidoacetic acid.
Claim 11
Dependent Claim
14 words
A method as set forth in claim 5 wherein said composition is sodium [2-(trifluoromethyl)benzamido]acetate.
Claim 12
Dependent Claim
19 words
A method as set forth in claim 5 wherein magnetic resonance images of blood flow and perfusion are enhanced.
Claim 13
Dependent Claim
17 words
A method as set forth in claim 5 wherein magnetic resonance images of the kidney are enhanced.
References Cited (Backward Citations)
US2135474A
Cited
US3859429A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-15 | 1990-03-17 | 1990-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-15 | 1994-03-17 | 1994-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-15 | 1998-03-17 | 1998-09-16 | $7700.00 | Window Closed / Lapsed |