US5230883A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for localization and treatment of tumors using polylysine complexes
Assignee: Wisconsin Alumni Research Foundation
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Filing: 1992-01-27
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Granted: 1993-07-27
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Expires: 2012-01-27
Abstract
Abstract Improved methods of selectively localizing, imaging and/or treating tumors, which have a net negative charge, employ novel compositions containing non-immunogenic complexes having a net positive charge in a sterile solution. The complexes contain polylysine, a linking agent bound to less than all of the lysyl groups of the polylysine, and an imaging agent or a chemotherapeutic agent which is also bound to the linking agent.
Inventors
- 👤 Steven Kornguth
- 👤 Patrick Turski
- 👤 H. Ian Robins
- 👤 Robert J. Nickles
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 18:32
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/14; A61K49/146; A61K49/085; A61K51/00; A61K51/02; A61K51/04; A61K51/08; A61K51/088; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/575; A61K2123/00; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
73 words
A method for the diagnostic imaging of a tumor having a high net negative charge in a human which comprises bringing into binding contact with said tumor in said human a diagnostically effective amount of a complex having a high net positive charge, said complex comprising polylysine, a linking agent bonded to less than about thirty percent of the lysyl groups of said polylysine and an imaging agent bonded to the linking agent.
Claim 2
Independent Claim
73 words
A method for the diagnostic imaging of a tumor having a high net negative charge in a human which comprises bringing into binding contact with said tumor in said human a diagnostically effective amount of a complex having a high net positive charge, said complex comprising polylysine, a linking agent bonded to less than about thirty percent of the lysyl groups of said polylysine and an imaging agent bonded to the linking agent.
Claim 3
Independent Claim
84 words
A method of selectively imaging with MR a tumor having a high net negative charge in an animal which comprises first administering to an animal having a tumor or suspected or having a tumor a diagnostically effective amount of a complex having a positive net charge and comprising polylysine having a linking agent bonded to less than about thirty percent of the lysyl groups thereof, said linking agent also being bound to an MR imaging agent; and, then subjecting the animal to MR imaging.
Claim 4
Independent Claim
84 words
A method of selectively imaging with MR a tumor having a high net negative charge in an animal which comprises first administering to an animal having a tumor or suspected or having a tumor a diagnostically effective amount of a complex having a positive net charge and comprising polylysine having a linking agent bonded to less than about thirty percent of the lysyl groups thereof, said linking agent also being bound to an MR imaging agent; and, then subjecting the animal to MR imaging.
Claim 5
Independent Claim
85 words
A method of delivering an MR imaging agent to a tumor having a net negative charge in an animal, said method comprising introducing into the bloodstream of an animal having such a tumor a diagnostically effective amount, a non-immunogenic complex having a net positive charge, said complex and comprising polylysine having covalently bonded to less than thirty percent of the lysyl groups thereof, a linking agent which also is attached to an MR imaging agent; and allowing the complex to be attracted to the tumor.
Claim 6
Independent Claim
85 words
A method of delivering an MR imaging agent to a tumor having a net negative charge in an animal, said method comprising introducing into the bloodstream of an animal having such a tumor a diagnostically effective amount, a non-immunogenic complex having a net positive charge, said complex and comprising polylysine having covalently bonded to less than thirty percent of the lysyl groups thereof, a linking agent which also is attached to an MR imaging agent; and allowing the complex to be attracted to the tumor.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-26 | 1997-01-25 | 1997-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-26 | 2001-01-25 | 2001-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-26 | 2005-01-25 | 2005-07-27 | $7700.00 | Window Closed / Lapsed |