US4855353A
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High molecular compounds having amino groups, and their utilization
Assignee: Nihon Medi Physics Co Ltd
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Filing: 1987-02-17
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Granted: 1989-08-08
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Expires: 2007-02-17
Abstract
Abstract A radioactive diagnostic or therapeutic agent, which comprises a metallic element-labeled high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group, at least one unit of (3) a physiologically active substance and (4) at least two radioactive metallic elements, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1) and each of the radioactive metallic element (4) being chelate-bonded to the chelate-forming compound (2).
Inventors
- 👤 Miki Kurami
- 👤 Yoshifumi Shirakami
- 👤 Keietsu Takahashi
- 👤 Nobuo Ueda
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 01:30
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/06; A61K51/065; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/62; A61K47/64; A61K47/645; A61K47/68; A61K47/6835; A61K47/6883; A61K51/08; A61K51/10; A61K51/1093; A61K2121/00; A61K2123/00; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/811; Y10S530/812; Y10S530/815; Y10S530/816
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
79 words
A reactive high molecular compound having at least one free amino group in a side chain which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule and at least two units of (2) a chelate-forming compound having a carboxyl group, each unit of the chelate-forming compound (2) being combined to any of the amino groups in the side chains of the polyamine compound (1) to form carbonamide linkage.
Claim 2
Dependent Claim
79 words
A reactive high molecular compound having at least one free amino group in a side chain which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule and at least two units of (2) a chelate-forming compound having a carboxyl group, each unit of the chelate-forming compound (2) being combined to any of the amino groups in the side chains of the polyamine compound (1) to form carbonamide linkage.
Claim 3
Dependent Claim
16 words
The reactive high molecular compound according to claim 1, wherein the polyamine compound (1) is polylysine.
Claim 4
Dependent Claim
16 words
The reactive high molecular compound according to claim 1, wherein the polyamine compound (1) is polyimine.
Claim 5
Dependent Claim
71 words
A reactive high molecular compound having at least two free amino groups in side chains which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule and at least one unit of (3) a physiologically active substance, each unit of the physiologically active substance (3) being combined to any of the amino groups in side chains of the polyamine compound (1).
Claim 6
Dependent Claim
71 words
A reactive high molecular compound having at least two free amino groups in side chains which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule and at least one unit of (3) a physiologically active substance, each unit of the physiologically active substance (3) being combined to any of the amino groups in side chains of the polyamine compound (1).
Claim 7
Dependent Claim
16 words
The reactive high molecular compound according to claim 4, wherein the polyamine compound (1) is polylysine.
Claim 8
Dependent Claim
16 words
The reactive high molecular compound according to claim 4, wherein the polyamine compound (1) is polyimine.
Claim 9
Dependent Claim
82 words
A physiologically active substance-combined high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group and at least one unit of (3) a physiologically active substance, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1).
Claim 10
Dependent Claim
82 words
A physiologically active substance-combined high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group and at least one unit of (3) a physiologically active substance, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1).
Claim 11
Dependent Claim
18 words
The physiologicall active substance-combined high molecular compound according to claim 7, wherein the polyamine compound (1) is polylysine.
Claim 12
Dependent Claim
18 words
The physiologically active substance-combined high molecular compound according to claim 7, wherein the polyamine compound (1) is polyimine.
Claim 13
Dependent Claim
104 words
A radioactive metallic element-labeled high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group, at least one unit of (3) a physiologically active substance and (4) at least two radioactive metallic element atoms, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1) and each radioactive metallic element atom (4) being chelate-bonded to the chelate-forming compound (2).
Claim 14
Dependent Claim
104 words
A radioactive metallic element-labeled high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group, at least one unit of (3) a physiologically active substance and (4) at least two radioactive metallic element atoms, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1) and each radioactive metallic element atom (4) being chelate-bonded to the chelate-forming compound (2).
Claim 15
Dependent Claim
18 words
The radioactive metallic element-labeled high molecular compound according to claim 10, wherein the polyamine compound (1) is polylysine.
Claim 16
Dependent Claim
18 words
The radioactive metallic element-labeled high molecular compound according to claim 10, wherein the polyamine compound (1) is polyimine.
Claim 17
Dependent Claim
16 words
A non-radioactive carrier which comprises the physiologically active substance-combined high molecular compound according to claim 7.
Claim 18
Dependent Claim
16 words
A radioactive agent which comprises the radioactive metallic element-labeled high molecular compound according to claim 10.
Claim 19
Dependent Claim
44 words
A process for preparing the reactive high molecular compound according to claim 1, which comprises reacting the polyamine compound (1) with the chelate-forming compound (2) to form a carbonamide linkage between an amino group in the former and a carboxyl group in the latter.
Claim 20
Dependent Claim
37 words
A process for preparing the reactive high molecular compound according to claim 4, which comprises reacting the polyamine compound (1) with the physiologically active substance (3) in the presence or absence of a binding or crosslinking agent.
Claim 21
Dependent Claim
186 words
A process for preparing a physiologically active substance-combined high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group and at least one unit of (3) a physiologically active substance, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amine groups in the side chains of the polyamine compound (1), said process comprising reacting a reactive high molecular compound having at least one free amino groups in a side chain which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule and at least two units of (2) a chelate-forming compound having a carboxyl group, each unit of the chelate-forming compound (2) being combined to any of the amino groups in the side chains of the polyamide compound (1) to form carbonamide linkage, with the physiologically active substance (3) in the presence or absence of a binding or crosslinking agent.
Claim 22
Dependent Claim
186 words
A process for preparing a physiologically active substance-combined high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group and at least one unit of (3) a physiologically active substance, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amine groups in the side chains of the polyamine compound (1), said process comprising reacting a reactive high molecular compound having at least one free amino groups in a side chain which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule and at least two units of (2) a chelate-forming compound having a carboxyl group, each unit of the chelate-forming compound (2) being combined to any of the amino groups in the side chains of the polyamide compound (1) to form carbonamide linkage, with the physiologically active substance (3) in the presence or absence of a binding or crosslinking agent.
Claim 23
Dependent Claim
184 words
A process for preparing a physiologically active substance-combined high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group and at least one unit of (3) a physiologically active substance, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amine groups in the side chains of the polyamine compound (1), said process comprising reacting a reactive high molecular compound having at least one free amino group which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule and at least one unit of (3) a physiologically active substance, each unit of the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1), with the chelate-forming compound (2) to form carbonamide linkage between amino group in side chain in the former and a carboxyl group in the latter.
Claim 24
Dependent Claim
184 words
A process for preparing a physiologically active substance-combined high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group and at least one unit of (3) a physiologically active substance, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amine groups in the side chains of the polyamine compound (1), said process comprising reacting a reactive high molecular compound having at least one free amino group which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule and at least one unit of (3) a physiologically active substance, each unit of the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1), with the chelate-forming compound (2) to form carbonamide linkage between amino group in side chain in the former and a carboxyl group in the latter.
Claim 25
Dependent Claim
200 words
A process for preparing a radioactive metallic element-labeled high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group, at least one unit of (3) a physiologically active substance and (4) at least two radioactive metallic element atoms, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1) and each radioactive metallic element atom (4) being chelate-bonded to the chelate-forming compound (2) , said process comprising reacting a physiologically active substance-combined high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group and at least one unit of (3) a physiologically active substance, each unit of chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1), with a radioactive metallic element atom.
Claim 26
Dependent Claim
200 words
A process for preparing a radioactive metallic element-labeled high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group, at least one unit of (3) a physiologically active substance and (4) at least two radioactive metallic element atoms, each unit of the chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1) and each radioactive metallic element atom (4) being chelate-bonded to the chelate-forming compound (2) , said process comprising reacting a physiologically active substance-combined high molecular compound which comprises one unit of (1) a polyamine compound having at least three amino groups in the side chains per molecule, at least two units of (2) a chelate-forming compound having a carboxyl group and at least one unit of (3) a physiologically active substance, each unit of chelate-forming compound (2) and the physiologically active substance (3) being combined to any of the amino groups in the side chains of the polyamine compound (1), with a radioactive metallic element atom.
References Cited (Backward Citations)
US4425319A
Cited
US4391945A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-08-07 | 1993-02-06 | 1993-08-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-08-07 | 1997-02-06 | 1997-08-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-08-07 | 2001-02-06 | 2001-08-08 | $7700.00 | Window Closed / Lapsed |