US4822594A
Expired / Lapsed
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Contrast enhancing agents for magnetic resonance images
Assignee: Individual
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Filing: 1987-01-27
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Granted: 1989-04-18
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Expires: 2007-01-27
Abstract
Abstract A saccharide matrix containing chelating agents. In a preferred embodiment the chelating agents, for example, EDTA or DTPA, bind metals having at least one unpaired electron. Such compositions are useful for enhancing the contrast of Magnetic Resonance images.
Inventors
- 👤 Wendell A. Gibby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:29
CPC Classifications
A; A61; A61K; A61K49/00; A61K49/06; A61K49/08; A61K49/10; A61K49/101; A61K49/103; A61K49/085; Y; Y10; Y10S; Y10S436/00; Y10S436/806; Y10T; Y10T436/00; Y10T436/24
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
84 words
A chelating agent represented by the formula: ##STR3## where m is 1, 2, or 3; n is an interger between 1 and 4; p can be independently varied and is an integer between 0 and 2; and X and Y can be --(CH 2 ) p COOH or X is (CH 2 ) n and joined to Y; at least one saccharide is bound to said chelating agent through an ester linkages of one of said (COOH) groups and (OH) groups of the saccharide.
Claim 2
Dependent Claim
84 words
A chelating agent represented by the formula: ##STR3## where m is 1, 2, or 3; n is an interger between 1 and 4; p can be independently varied and is an integer between 0 and 2; and X and Y can be --(CH 2 ) p COOH or X is (CH 2 ) n and joined to Y; at least one saccharide is bound to said chelating agent through an ester linkages of one of said (COOH) groups and (OH) groups of the saccharide.
Claim 3
Dependent Claim
26 words
A composition of matter comprising the chelating agent of claim 1 and a metal ion having at least one unpaired electron chelated to said chelating agent.
Claim 4
Dependent Claim
19 words
The compound of claim 1 wherein said chelating agent is selected from the group of EDTA, DTPA, and DOTA.
Claim 5
Dependent Claim
15 words
The compound of claim 3 wherein said saccharide is selected from dextran, glucose and maltose.
Claim 6
Dependent Claim
26 words
The compound of claim 4 wherein said saccharide is a polymer and said saccharide is bound to said chelating agent through at least two ester linkages.
Claim 7
Dependent Claim
17 words
The compound of claim 2 wherein said metal ion is selected from the lanthanide group of metals.
Claim 8
Dependent Claim
11 words
The compound of claim 6 wherein said metal ion is Gd.
Claim 9
Dependent Claim
21 words
The compound of claim 2 wherein said metal ion is selected from the group consisting of Cr, Mn, Fe and Co.
Claim 10
Dependent Claim
22 words
A composition of matter comprising the chelating agent of claim 1 and an excipient for administration to a patient for MR tomography.
Claim 11
Dependent Claim
31 words
A method of enhacning MR contrast in a living subject, comprising administering internally to the subject an effective amount of a contrast agent which comprises the chelating agent of claim 1.
Claim 12
Dependent Claim
29 words
A method for the treatment of heavy metal poisoning in a living subject, comprising administering internally to the subject an effective amount of the chelating agent of claim 1.
Claim 13
Dependent Claim
22 words
A method for producing ion exchange columns which comprises employing the chelating agent of claim 1 as the ion exchange column packing.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-04-17 | 1992-10-17 | 1993-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-04-17 | 1996-10-17 | 1997-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-04-17 | 2000-10-17 | 2001-04-18 | $7700.00 | Window Closed / Lapsed |