US5587070A
Expired / Lapsed
US
⏱️ 0.0 years remaining
System for processing biological fluid
Assignee: Haemonetics Puerto Rico LLC
•
Filing: 1993-06-04
•
Granted: 1996-12-24
•
Expires: 2013-06-04
Abstract
Abstract A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system may also include one or more of the following: a red cell barrier medium, a separation medium, a gas inlet, and a gas outlet. The system can be used to centrifuge whole blood into one or more components, and includes a means for protecting the system during centrifugation.
Inventors
- 👤 David B. Pall
- 👤 Thomas C. Gsell
- 👤 Vlado I. Matkovich
- 👤 Thomas Bormann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 09:58
CPC Classifications
B; B01; B01D; B01D63/00; B01D63/08; B01D63/087; A; A61; A61J; A61J1/00; A61J1/05; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/0218; A61M1/0227; A61M1/0231; A61M1/025; A61M1/029; A61M1/34; A61M1/3472; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M1/3643; A61M1/3644; A61M1/3646; A61M1/3652; B01D61/00; B01D61/14; B01D61/145; B01D61/147; B01D61/16; B01D61/20; B01D61/22; B01D65/00; B01D65/08; A61J1/10; A61M1/3693; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2202/0427; A61M2202/0429; A61M2202/0439; A61M2206/00; A61M2206/10; A61M2206/12; A61M5/00; A61M5/14; A61M5/142; A61M5/145; A61M5/148; A61M5/1483; A61M5/1486; B01D2321/00; B01D2321/20; B01D2321/2083
Claims Analysis
Total Claims: 35
Claim 1
Independent Claim
208 words
A biological fluid processing system comprising: a first container; a first porous medium communicating with the first container and comprising a red cell barrier medium or a combined leukocyte depletion and red cell barrier medium, said red cell barrier medium being capable of separating a red cell-containing portion of a biological fluid from a non red cell-containing portion of the biological fluid; and a separation device downstream of, and communicating with, the first porous medium, said device comprising a housing and including a separation medium; said housing having an inlet, a first outlet, and a second outlet; said separation medium having a first surface and a second surface, and comprising at least one porous membrane, said separation medium being suitable for passing a biological fluid including plasma and at least one other component of the biological fluid along the first surface of the separation medium and for passing plasma through the separation medium, said separation medium positioned inside the housing to provide a first fluid flow path for the biological fluid from the inlet along the first surface of the separation medium to the first outlet, and a second fluid flow for passing plasma through the first and second surfaces of the separation medium to the second outlet.
Claim 2
Dependent Claim
208 words
A biological fluid processing system comprising: a first container; a first porous medium communicating with the first container and comprising a red cell barrier medium or a combined leukocyte depletion and red cell barrier medium, said red cell barrier medium being capable of separating a red cell-containing portion of a biological fluid from a non red cell-containing portion of the biological fluid; and a separation device downstream of, and communicating with, the first porous medium, said device comprising a housing and including a separation medium; said housing having an inlet, a first outlet, and a second outlet; said separation medium having a first surface and a second surface, and comprising at least one porous membrane, said separation medium being suitable for passing a biological fluid including plasma and at least one other component of the biological fluid along the first surface of the separation medium and for passing plasma through the separation medium, said separation medium positioned inside the housing to provide a first fluid flow path for the biological fluid from the inlet along the first surface of the separation medium to the first outlet, and a second fluid flow for passing plasma through the first and second surfaces of the separation medium to the second outlet.
Claim 3
Dependent Claim
34 words
The system of claim 1 further comprising a second container and a third container, wherein the second container is downstream of the first outlet, and the third container is downstream of the second outlet.
Claim 4
Dependent Claim
34 words
The system of claim 1 wherein the separation medium is positioned inside the housing to provide the first fluid flow path for the biological fluid tangentially to the first surface of the separation medium.
Claim 5
Dependent Claim
27 words
The system of claim 3 wherein at least one of said first fluid flow path and second fluid flow path include at least one fluid flow channel.
Claim 6
Dependent Claim
16 words
The system of claim 4 wherein said fluid flow channel comprises a serpentine fluid flow channel.
Claim 7
Dependent Claim
22 words
The system of claim 4 wherein said first fluid flow path includes at least one fluid flow channel that varies in depth.
Claim 8
Dependent Claim
25 words
The system of claim 6 wherein said fluid flow channel is shallower at the end of the channel that at the beginning of the channel.
Claim 9
Dependent Claim
40 words
The system of claim 6 wherein said first fluid flow path includes several fluid flow channels that vary in depth, wherein said fluid flow channels are shallower at the end of the channels that at the beginning of the channels.
Claim 10
Dependent Claim
22 words
The system of claim 4 wherein the porous membrane comprises a porous sheet, and the first fluid flow path includes several channels.
Claim 11
Dependent Claim
23 words
The system of claim 4 wherein said first fluid flow path includes at least one fluid flow channel comprising a serpentine flow channel.
Claim 12
Dependent Claim
20 words
The system of claim 4 wherein said first fluid flow path includes several fluid flow channels comprising serpentine flow channels.
Claim 13
Dependent Claim
16 words
The system of claim 4 wherein the first fluid flow path includes several fluid flow channels.
Claim 14
Dependent Claim
34 words
The system of claim 12 wherein the red cell barrier medium or the combined leukocyte depletion and red cell barrier medium comprises a fibrous medium having a CWST of about 70 dynes/cm or more.
Claim 15
Dependent Claim
18 words
The system of claim 13 wherein the fibrous medium has a CWST of about 90 dynes/cm or more.
Claim 16
Dependent Claim
19 words
The system of claim 14 wherein the fibrous medium has a negative zeta potention at a pH of 7.3.
Claim 17
Dependent Claim
29 words
The system of claim 12 wherein the combined leukocyte depletion medium and red cell barrier medium is capable of providing a leukocyte depletion efficiency in excess of about 99.9%.
Claim 18
Dependent Claim
13 words
The system of claim 12 wherein the separation medium comprises a polyamide membrane.
Claim 19
Dependent Claim
20 words
The system of claim 17 wherein the polyamide membrane has an effective pore size of less than about 4 micometers.
Claim 20
Dependent Claim
16 words
The system of claim 18 wherein the effective pore size is less than about 2 micrometers.
Claim 21
Independent Claim
206 words
A system comprising: a first container; a first porous medium communicating with the first container, said first porous medium comprising a leukocyte depletion medium; and a separation device downstream of, and communicating with, the first porous medium, said device comprising a housing and including a separation medium; said housing having an inlet, a first outlet, and a second outlet; said separation medium having a first surface and a second surface, and comprising at least one porous membrane, said separation medium being suitable for passing a biological fluid including plasma and at least one other component of the biological fluid along the first surface of the separation medium and for passing plasma through the separation medium, said separation medium positioned inside the housing to provide a first fluid flow path for the biological fluid from the inlet along the first surface of the separation medium to the first outlet, wherein said first fluid flow path includes at least one fluid flow channel which decreases in cross-sectional area and decreases in depth along the length of the channel from the inlet to the first outlet; and a second fluid flow path for passing plasma through the first and second surfaces of the separation medium to the second outlet.
Claim 22
Independent Claim
206 words
A system comprising: a first container; a first porous medium communicating with the first container, said first porous medium comprising a leukocyte depletion medium; and a separation device downstream of, and communicating with, the first porous medium, said device comprising a housing and including a separation medium; said housing having an inlet, a first outlet, and a second outlet; said separation medium having a first surface and a second surface, and comprising at least one porous membrane, said separation medium being suitable for passing a biological fluid including plasma and at least one other component of the biological fluid along the first surface of the separation medium and for passing plasma through the separation medium, said separation medium positioned inside the housing to provide a first fluid flow path for the biological fluid from the inlet along the first surface of the separation medium to the first outlet, wherein said first fluid flow path includes at least one fluid flow channel which decreases in cross-sectional area and decreases in depth along the length of the channel from the inlet to the first outlet; and a second fluid flow path for passing plasma through the first and second surfaces of the separation medium to the second outlet.
Claim 23
Dependent Claim
38 words
The system of claim 20 wherein said first fluid flow path includes several fluid flow channels that decrease in cross-sectional are and decrease in depth along the length of the channel from the inlet to the first outlet.
Claim 24
Dependent Claim
13 words
The system of claim 21 wherein the separation medium comprises a polycarbonate membrane.
Claim 25
Dependent Claim
13 words
The system of claim 21 wherein the separation medium comprises a polyamide membrane.
Claim 26
Dependent Claim
34 words
The system of claim 20 further comprising a second container and a third container, wherein the second container is downstream of the first outlet, and the third container is dowmstream of the second outlet.
Claim 27
Dependent Claim
23 words
The system of claim 24 wherein the leukocyte depletion medium comprises a fibrous medium having a CWST of about 60 dynes/cm or more.
Claim 28
Dependent Claim
193 words
A biological fluid processing system comprising: a first container; a first porous medium communicating with the first container, said first porous medium comprising a leukocyte depletion medium; and a separation device downstream of, and communicating with, the first porous medium, said device comprising a housing and including a separation medium; said housing having an inlet, a first outlet, and a second outlet; said separation medium having a first surface and a second surface, and comprising at least one porous membrane, said separation medium being suitable for passing a biological fluid including plasma and at least one other component of the biological fluid along the first surface of the separation medium and for passing plasma through the separation medium, said separation medium positioned inside the housing to provide a first fluid flow path for the biological fluid from the inlet along the first surface of the separation medium to the first outlet, wherein said first fluid flow path includes at least one fluid flow channel which comprises a serpentine flow channel; and a second fluid flow path for passing plasma through the first and second surfaces of the separation medium to the second outlet.
Claim 29
Dependent Claim
193 words
A biological fluid processing system comprising: a first container; a first porous medium communicating with the first container, said first porous medium comprising a leukocyte depletion medium; and a separation device downstream of, and communicating with, the first porous medium, said device comprising a housing and including a separation medium; said housing having an inlet, a first outlet, and a second outlet; said separation medium having a first surface and a second surface, and comprising at least one porous membrane, said separation medium being suitable for passing a biological fluid including plasma and at least one other component of the biological fluid along the first surface of the separation medium and for passing plasma through the separation medium, said separation medium positioned inside the housing to provide a first fluid flow path for the biological fluid from the inlet along the first surface of the separation medium to the first outlet, wherein said first fluid flow path includes at least one fluid flow channel which comprises a serpentine flow channel; and a second fluid flow path for passing plasma through the first and second surfaces of the separation medium to the second outlet.
Claim 30
Dependent Claim
17 words
The system of claim 26 further comprising at least one fluid flow channel which varies in depth.
Claim 31
Dependent Claim
14 words
The system of claim 26 wherein the first fluid flow path includes several channels.
Claim 32
Dependent Claim
13 words
The system of claim 28 wherein the separation medium comprises a polycarbonate membrane.
Claim 33
Dependent Claim
13 words
The system of claim 28 wherein the separation medium comprises a polyamide membrane.
Claim 34
Dependent Claim
34 words
The system of claim 26 further comprising a second container and a third container, wherein the second container is downstream of the first outlet, and the third container is downstream of the second outlet.
Claim 35
Dependent Claim
23 words
The system of claim 31 wherein the leukocyte depletion medium comprises a fibrous medium having a CWST of about 60 dynes/cm or more.
References Cited (Backward Citations)
US3623610A
Cited
US3610418A
Cited
US3705100A
Cited
US4075091A
Cited
US4111199A
Cited
US4178248A
Cited
US4330410A
Cited
US4212742A
Cited
US4447220A
Cited
US4416777A
Cited
US4381775A
Cited
CA1158988A
Cited
US4619639A
Cited
US4322298A
Cited
US4746436A
Cited
US4753733A
Cited
US4543084A
Cited
US4769150A
Cited
US4596657A
Cited
US4919823A
Cited
US4767541A
Cited
US4680025A
Cited
US4636309A
Cited
US4636310A
Cited
US4639243A
Cited
US4888115A
Cited
CA1249110A
Cited
US4604208A
Cited
US4675117A
Cited
US4800022A
Cited
WO1986005410A1
Cited
US4806247A
Cited
JPS61253071A
Cited
US4753739A
Cited
EP0267286A1
Cited
US4810378A
Cited
US4855063A
Cited
US4915848A
Cited
US4845132A
Cited
US4714457A
Cited
US4898573A
Cited
US4980297A
Cited
US5049268A
Cited
US4925572A
Cited
US4923620A
Cited
US4909949A
Cited
US4995967A
Cited
US4880548A
Cited
EP0329303A1
Cited
EP0336483A1
Cited
US4985153A
Cited
US4892668A
Cited
US4933092A
Cited
US5229012A
Cited
US5069789A
Cited
US5008012A
Cited
EP0399083A1
Cited
US4943287A
Cited
EP0414006A1
Cited
WO1991004088A1
Cited
US5258126A
Cited
US5152905A
Cited
US5013437A
Cited
US4997577A
Cited
US5266219A
Cited
US5102407A
Cited
EP0446713A2
Cited
EP0455215A2
Cited
WO1991017809A1
Cited
EP0464707A2
Cited
US5258127A
Cited
US5217627A
Cited
WO1992007656A2
Cited
US5100564A
Cited
EP0531540A1
Cited
WO1992020383A1
Cited
WO1993008904A1
Cited
WO1993025295A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-12-24 | 2000-06-24 | 2000-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-12-24 | 2004-06-24 | 2004-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-12-24 | 2008-06-24 | 2008-12-24 | $7700.00 | Window Closed / Lapsed |