Patent US5492894A successfully refreshed from Google Patents.
US5492894A
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Compositions for treating wrinkles comprising a peptide
Assignee: Procter and Gamble Co
•
Filing: 1993-06-25
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Granted: 1996-02-20
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Expires: 2013-06-25
Abstract
Abstract The present invention relates to topical compositions comprising a peptide having the formula Qa-(Xaa)n-Qc wherein Qa is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; Qc is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino; n is an integer selected from the group consisting of 3, 4, 5 and 6; Xaa is independently any amino acid; and at least three of the amino acids are selected from the group consisting of arginine and lysine.
Inventors
- 👤 Charles C. Bascom
- 👤 Andrew W. Fulmer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:27
CPC Classifications
A; A61; A61Q; A61Q19/00; A61Q19/08; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/64
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
115 words
A topical composition comprising: a) peptide useful for cosmetic treatment of mammalian skin wrinkles having the amino acid sequence Q.sup.a -(Xaa).sub.n -Q.sup.c wherein Q a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; Q c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (allcyl)(arylalkyl)amino, (aryl)(arylaikyl)amino, and amino; n is from 3 to 6; Xaa is independently any amino acid; wherein at least three of the Xaa are independently selected from the group consisting of arginine and lysine; and b) a pharmaceutically-acceptable carrier or cosmetically-acceptable carrier, wherein the carrier is a topical carrier comprising an emollient.
Claim 2
Dependent Claim
115 words
A topical composition comprising: a) peptide useful for cosmetic treatment of mammalian skin wrinkles having the amino acid sequence Q.sup.a -(Xaa).sub.n -Q.sup.c wherein Q a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; Q c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (allcyl)(arylalkyl)amino, (aryl)(arylaikyl)amino, and amino; n is from 3 to 6; Xaa is independently any amino acid; wherein at least three of the Xaa are independently selected from the group consisting of arginine and lysine; and b) a pharmaceutically-acceptable carrier or cosmetically-acceptable carrier, wherein the carrier is a topical carrier comprising an emollient.
Claim 3
Dependent Claim
47 words
The composition of claim 1 which comprises from about 0.001% to about 20% of the peptide, wherein Xaa is independently selected from the group consisting of Ala, Arg, Asn, Asp, Cys, GIn, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr and Val.
Claim 4
Dependent Claim
21 words
The composition of claim 2 wherein at least two of Xaa are Arg and at least one of Xaa is Lys.
Claim 5
Dependent Claim
15 words
The composition of claim 3 wherein Q a is hydrogen and Q c is hydroxy.
Claim 6
Dependent Claim
13 words
The composition of claim 4 wherein the peptide is H-Arg-Ser-Arg-Lys-OH (SEQ ID NO:3).
Claim 7
Dependent Claim
9 words
The composition of claim 4 wherein n is 3.
Claim 8
Dependent Claim
10 words
The composition of claim 6 wherein the peptide is H-Arg-Lys-Arg-OH.
Claim 9
Dependent Claim
14 words
The composition of claim 3 wherein the peptide is H 3 C-C(O)-Arg-Lys-Arg-NH 2 .
Claim 10
Dependent Claim
9 words
The composition of claim 4 wherein n is 4.
Claim 11
Dependent Claim
14 words
The composition of claim 9 wherein the peptide is H-Arg-Gly-Arg-Lys-OH (SEQ ID NO: 1).
Claim 12
Dependent Claim
17 words
The composition of claim 3 wherein Q a is hydrogen and Q c is NH 2 .
Claim 13
Dependent Claim
12 words
The composition of claim 11 wherein the peptide is H-Lys-Arg-Ser-Arg-NH 2 .
Claim 14
Dependent Claim
39 words
The composition of claim 1 which additionally comprises a safe and effective amount of an active selected from the group consisting of a sunscreening agent, an anti-inflammatory agent, an anti-oxidant/radical scavenging agent, a chelator, a retinoid, and N-acetyl cysteine.
Claim 15
Dependent Claim
27 words
The composition of claim 1 which additionally comprises a safe and effective amount of a sunscreening agent and a safe and effective amount of an anti-inflammatory agent.
Claim 16
Independent Claim
136 words
A method for the cosmetic treatment of mammalian skin wrinkles comprising topically applying to mammalian skin in need of such treatment a composition comprising: a) peptide useful for the cosmetic treatment of mammalian skin wrinkles having the areinc acid sequence Q.sup.a -(Xaa).sub.n -Q.sup.c wherein Q a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; Q c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, allcylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino; n is from 3 to 6; Xaa is independently any areinc acid; wherein at least three of the Xaa are independently selected from the group consisting of arginine and lysine; and b) a pharmaceutically-acceptable carrier or cosmetically-acceptable carrier wherein the carrier is a topical carrier comprising an emollient.
Claim 17
Independent Claim
136 words
A method for the cosmetic treatment of mammalian skin wrinkles comprising topically applying to mammalian skin in need of such treatment a composition comprising: a) peptide useful for the cosmetic treatment of mammalian skin wrinkles having the areinc acid sequence Q.sup.a -(Xaa).sub.n -Q.sup.c wherein Q a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; Q c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, allcylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino; n is from 3 to 6; Xaa is independently any areinc acid; wherein at least three of the Xaa are independently selected from the group consisting of arginine and lysine; and b) a pharmaceutically-acceptable carrier or cosmetically-acceptable carrier wherein the carrier is a topical carrier comprising an emollient.
Claim 18
Dependent Claim
21 words
The method of claim 15 wherein at least two of Xaa are Arg and at least one of Xaa is Lys.
Claim 19
Dependent Claim
10 words
The method of claim 16 wherein the peptide is H-Arg-Lys-Arg-OH.
Claim 20
Dependent Claim
14 words
The method of claim 16 wherein the peptide is H 3 C-C(O)-Arg-Lys-Arg-NH 2 .
Claim 21
Dependent Claim
14 words
The method of claim 16 wherein the peptide is H-Arg-Gly-Arg-Lys-OH (SEQ ID NO: 1).
Claim 22
Dependent Claim
12 words
The method of claim 16 wherein the peptide is H-Lys-Arg-Ser-Arg-NH 2 .
Claim 23
Dependent Claim
14 words
The method of claim 16 wherein the peptide is H-Arg-Ser-Arg-Lys-OH (SEQ ID NO: 3).
Claim 24
Dependent Claim
67 words
A peptide useful for the cosmetic treatment of mammalian skin wrinkJes having the amino acid sequence Q a -Arg-Lys-Arg-Q c , wherein Q a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; and Q c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino.
Claim 25
Dependent Claim
67 words
A peptide useful for the cosmetic treatment of mammalian skin wrinkJes having the amino acid sequence Q a -Arg-Lys-Arg-Q c , wherein Q a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; and Q c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino.
Claim 26
Dependent Claim
15 words
The peptide of claim 22 wherein Q a is hydrogen and Q c is hydroxy.
Claim 27
Dependent Claim
17 words
The peptide of claim 22 wherein Q a is H 3 C--C(O)-- and Q c is amino.
Claim 28
Dependent Claim
67 words
A peptide useful for the cossmetic treatment of mammalian skin wrinkles having the amino acid sequence Q a -Arg-Gly-Arg-Lys-Q c , wherein Q a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; and Q c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino.
Claim 29
Dependent Claim
67 words
A peptide useful for the cossmetic treatment of mammalian skin wrinkles having the amino acid sequence Q a -Arg-Gly-Arg-Lys-Q c , wherein Q a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; and Q c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, alkylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino.
Claim 30
Dependent Claim
20 words
The peptide of claim 25 wherein Q a is hydrogen and Q c is hydroxy (SEQ ID NO: 1 ).
Claim 31
Dependent Claim
67 words
A peptide useful for the cosmetic treatment of mammalian skin wrinkles having the amino acid sequence Q a -Lys-Arg-Ser-Arg-Q c , wherein Q a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; and Q c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, allcylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino.
Claim 32
Dependent Claim
67 words
A peptide useful for the cosmetic treatment of mammalian skin wrinkles having the amino acid sequence Q a -Lys-Arg-Ser-Arg-Q c , wherein Q a is selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, alkyloyl, aryloyl, arylalkyloyl, alkyloxoyl, aryloxoyl and arylalkyloxoyl; and Q c is selected from the group consisting of hydroxy, alkyloxy, aryloxy, arylalkyloxy, allcylamino, dialkylamino, arylamino, diarylamino, (aryl)(alkyl)amino, arylalkylamino, diarylalkylamino, (alkyl)(arylalkyl)amino, (aryl)(arylalkyl)amino, and amino.
Claim 33
Dependent Claim
17 words
The peptide of claim 27 wherein Q a is hydrogen and Q c is -NH 2 .
Claim 34
Dependent Claim
111 words
A topical composition comprising: a) a safe and effective amount of a peptide useful for the cosmetic treatment of mammalian skin wrinkles having the amino acid sequence Q.sup.a -(Xaa)n Arg Ser Arg Lys (Xaa)n-Q.sup.c wherein each n is independently an integer selected from the group consisting of 0, 1, 2 and 3, each Xaa is independently any amino acid, each amino acid is protected or unprotected, Q a is selected from the group consisting of hydrogen and an amino-terminus blocking group, and Q c is selected from the group consisting of hydrogen and a carboxy-terminus blocking group; and b) a safe and effective mount of a topical carrier comprising an emollient.
Claim 35
Dependent Claim
111 words
A topical composition comprising: a) a safe and effective amount of a peptide useful for the cosmetic treatment of mammalian skin wrinkles having the amino acid sequence Q.sup.a -(Xaa)n Arg Ser Arg Lys (Xaa)n-Q.sup.c wherein each n is independently an integer selected from the group consisting of 0, 1, 2 and 3, each Xaa is independently any amino acid, each amino acid is protected or unprotected, Q a is selected from the group consisting of hydrogen and an amino-terminus blocking group, and Q c is selected from the group consisting of hydrogen and a carboxy-terminus blocking group; and b) a safe and effective mount of a topical carrier comprising an emollient.
Claim 36
Dependent Claim
29 words
A method for the cosmetic treatment of mammalian skin wrinkles in mammalian skin comprising treating the skin with a safe and effective amount of the composition of claim 29.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1999-02-19 | 1999-08-21 | 2000-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-02-19 | 2003-08-21 | 2004-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-02-19 | 2007-08-21 | 2008-02-20 | $7700.00 | Window Closed / Lapsed |