US5314989A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Absorbable composition
Assignee: United States Surgical Corp
•
Filing: 1993-05-03
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Granted: 1994-05-24
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Expires: 2013-05-03
Abstract
Abstract A block copolymer for use in the fabrication of bioabsorbable articles such as monofilament surgical sutures is prepared by copolymerizing one or more hard phase forming monomers and 1,4-dioxan-2-one, and then polymerizing one or more hard phase forming monomers with the dioxanone-containing copolymer.
Inventors
- 👤 John Kennedy
- 👤 Donald S. Kaplan
- 👤 Ross R. Muth
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 11:38
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/66; C08G63/664; A; A61; A61L; A61L17/00; A61L17/06; A61L17/10; A61L17/12; C08G63/02; C08G63/06; C08G63/08
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
51 words
A block copolymer which comprises a proportion of units of one or more hard phase forming monomers as one of said blocks, and another of said blocks comprising a proportion of units having the formula: ##STR4## randomly combined with a proportion of units of one or more hard phase forming monomers.
Claim 2
Dependent Claim
51 words
A block copolymer which comprises a proportion of units of one or more hard phase forming monomers as one of said blocks, and another of said blocks comprising a proportion of units having the formula: ##STR4## randomly combined with a proportion of units of one or more hard phase forming monomers.
Claim 3
Dependent Claim
14 words
The block copolymer of claim 1 wherein said block copolymer is a diblock copolymer.
Claim 4
Dependent Claim
27 words
The block copolymer of claim 1 wherein said one or more hard phase forming monomers are selected from the group consisting of glycolide, lactide and mixtures thereof.
Claim 5
Dependent Claim
27 words
The block copolymer of claim 1 wherein from about 1 weight % to about 20 weight % of the block copolymer comprises units having the formula: ##STR5##
Claim 6
Dependent Claim
30 words
The block copolymer of claim 1 wherein the hard phase forming monomers comprise about 10 weight % to about 40 weight % of the block containing units of formula: ##STR6##
Claim 7
Dependent Claim
56 words
A surgical article manufactured from a block copolymer which comprises a proportion of units of one or more hard phase forming monomers as one of said blocks, and another of said blocks comprising a proportion of units having the formula: ##STR7## randomly combined with a proportion of units of one or more hard phase forming monomers.
Claim 8
Dependent Claim
56 words
A surgical article manufactured from a block copolymer which comprises a proportion of units of one or more hard phase forming monomers as one of said blocks, and another of said blocks comprising a proportion of units having the formula: ##STR7## randomly combined with a proportion of units of one or more hard phase forming monomers.
Claim 9
Dependent Claim
14 words
The surgical article of claim 6 wherein said block copolymer is a diblock copolymer.
Claim 10
Dependent Claim
13 words
The surgical article of claim 6 wherein said surgical article is a suture.
Claim 11
Dependent Claim
13 words
The surgical article of claim 8 wherein said suture is a monofilament suture.
Claim 12
Dependent Claim
27 words
The surgical article of claim 6 wherein from about 1 weight % to about 20 weight % of the block copolymer comprises units having the formula: ##STR8##
Claim 13
Independent Claim
59 words
A method for preparing a bioabsorbable block copolymer, comprising: a) polymerizing a mixture of one or more hard phase forming monomers and 1,4-dioxan-2-one at a first reaction temperature to create a copolymer thereof; b) polymerizing one or more hard phase forming monomers with the copolymer of step (a) at a second reaction temperature to create the bioabsorbable block copolymer.
Claim 14
Independent Claim
59 words
A method for preparing a bioabsorbable block copolymer, comprising: a) polymerizing a mixture of one or more hard phase forming monomers and 1,4-dioxan-2-one at a first reaction temperature to create a copolymer thereof; b) polymerizing one or more hard phase forming monomers with the copolymer of step (a) at a second reaction temperature to create the bioabsorbable block copolymer.
Claim 15
Dependent Claim
13 words
The method of claim 11 wherein said block copolymer is a diblock copolymer.
Claim 16
Dependent Claim
22 words
The method of claim 11 wherein said first reaction temperature comprises a temperature of from about 100° C. to about 150° C.
Claim 17
Dependent Claim
22 words
The method of claim 11 wherein said second reaction temperature comprises a temperature of from about 200° C. to about 250° C.
Claim 18
Dependent Claim
18 words
The method of claim 11 wherein step (a) is carried out in the presence of a polymerization catalyst.
Claim 19
Dependent Claim
11 words
The method of claim 15 wherein said catalyst is stannous octoate.
Claim 20
Dependent Claim
59 words
The method of claim 15 wherein said catalyst is selected from the group consisting of stannous chloride, dibutyl tin dilaurate, dibutyl tin diacetate, dibutyl tin dichloride, stannic chloride pentahydrate, aluminum isopropoxide, antimony trioxide, stannic fluoride, stannous citrate, stannous acetate, antimony trifluoride, tin tetraisopropoxide, lead oxide, tetraisopropyl titanate, titanium acetyl acetonate, tetraoctylene glycol titanate, boron trifluoride etherate, and aluminum trichloride.
Claim 21
Independent Claim
68 words
A method for making a bioabsorbable surgical article, comprising: a) polymerizing a mixture of one or more hard phase forming monomers and 1,4-dioxan-2-one at a first reaction temperature to create a copolymer thereof; b) polymerizing one or more hard phase forming monomers with the copolymer of step (a) at a second reaction temperature to create a bioabsorbable block copolymer; c) forming a surgical article from said block copolymer.
Claim 22
Independent Claim
68 words
A method for making a bioabsorbable surgical article, comprising: a) polymerizing a mixture of one or more hard phase forming monomers and 1,4-dioxan-2-one at a first reaction temperature to create a copolymer thereof; b) polymerizing one or more hard phase forming monomers with the copolymer of step (a) at a second reaction temperature to create a bioabsorbable block copolymer; c) forming a surgical article from said block copolymer.
Claim 23
Dependent Claim
19 words
The method of claim 18 wherein said forming includes the step of extruding the block copolymer into a filament.
Claim 24
Dependent Claim
13 words
The method of claim 19 wherein the bioabsorbable surgical article comprises a suture.
Claim 25
Dependent Claim
14 words
The method of claim 20 additionally comprising drawing the suture and relaxing the suture.
Claim 26
Dependent Claim
13 words
The method of claim 18 wherein said block copolymer is a diblock copolymer.
Claim 27
Dependent Claim
22 words
The method of claim 18 wherein said first reaction temperature comprises a temperature of from about 100° C. to about 150° C.
Claim 28
Dependent Claim
22 words
The method of claim 18 wherein said second reaction temperature comprises a temperature of from about 200° C. to about 250° C.
Claim 29
Dependent Claim
18 words
The method of claim 18 wherein step (a) is carried out in the presence of a polymerization catalyst.
Claim 30
Dependent Claim
11 words
The method of claim 25 wherein said catalyst is stannous octoate.
Claim 31
Dependent Claim
59 words
The method of claim 25 wherein said catalyst is selected from the group consisting of stannous chloride, dibutyl tin dilaurate, dibutyl tin diacetate, dibutyl tin dichloride, stannic chloride pentahydrate, aluminum isopropoxide, antimony trioxide, stannic fluoride, stannous citrate, stannous acetate, antimony trifluoride, tin tetraisopropoxide, lead oxide, tetraisopropyl titanate, titanium acetyl acetonate, tetraoctylene glycol titanate, boron trifluoride etherate, and aluminum trichloride.
Claim 32
Dependent Claim
25 words
The method of claim 18 wherein from about 55 weight % to about 85 weight % of the block copolymer comprises units derived from glycolide.
Claim 33
Dependent Claim
25 words
The method of claim 18 wherein from about 1 weight % to about 20 weight % of the block copolymer comprises units derived from lactide.
Claim 34
Dependent Claim
25 words
The method of claim 18 wherein from about 10 weight % to about 40 weight % of the block copolymer comprises units derived from 1,4-dioxan-2-one.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-05-23 | 1997-11-22 | 1998-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-05-23 | 2001-11-22 | 2002-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-05-23 | 2005-11-22 | 2006-05-24 | $7700.00 | Window Closed / Lapsed |