US4052988A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthetic absorbable surgical devices of poly-dioxanone
Assignee: Ethicon Inc
•
Filing: 1976-01-12
•
Granted: 1977-10-11
•
Expires: 1996-01-12
Abstract
Abstract Synthetic absorbable sutures and other surgical devices are prepared from polymers of p-dioxanone and 1,4-dioxepan-2-one, and alkyl substituted derivatives thereof. Monofilament sutures of oriented fibers are characterized by good tensile and knot strength and a high level of flexibility and softness. The sutures have good in vivo strength retention and are slowly absorbed without significant tissue reaction.
Inventors
- 👤 Namassivaya Doddi
- 👤 Charles C. Versfelt
- 👤 David Wasserman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 18:32
CPC Classifications
C; C08; C08G; C08G63/00; C08G63/66; C08G63/664; A; A61; A61B; A61B17/00; A61B17/04; A61B17/06; A61B17/06166; A61L; A61L17/00; A61L17/06; A61L17/10; A61L17/105; A61L27/00; A61L27/14; A61L27/18; A61B2017/00004
Claims Analysis
Total Claims: 45
Claim 1
Independent Claim
89 words
A sterile, synthetic absorbable suture comprising oriented fiber of a polymer of a monomer having the formula: ##STR4## wherein R' and R are individually hydrogen, methyl or ethyl, said suture being dry to the extent of being substantially free of moisture, and characterized by a Young's modulus of less than about 600,000 psi with a correspondingly high degree of softness and flexibility, an initial straight tensile and knot strength of at least about 40,000 psi and 30,000 psi respectively, and substantially complete absorption in vivo within about 180 days.
Claim 2
Dependent Claim
89 words
A sterile, synthetic absorbable suture comprising oriented fiber of a polymer of a monomer having the formula: ##STR4## wherein R' and R are individually hydrogen, methyl or ethyl, said suture being dry to the extent of being substantially free of moisture, and characterized by a Young's modulus of less than about 600,000 psi with a correspondingly high degree of softness and flexibility, an initial straight tensile and knot strength of at least about 40,000 psi and 30,000 psi respectively, and substantially complete absorption in vivo within about 180 days.
Claim 3
Dependent Claim
16 words
A suture of claim 1 wherein R and R' are hydrogen and the monomer is p-dioxanone.
Claim 4
Dependent Claim
29 words
A suture of claim 2 wherein said polymer is characterized by an inherent viscosity greater than about 0.50 measured as 0.1% solution of polymer in tetrachloroethane at 25° C.
Claim 5
Dependent Claim
10 words
A suture of claim 3 comprising a homopolymer of p-dioxanone.
Claim 6
Dependent Claim
10 words
A suture of claim 1 comprising a polymer of methyl-p-dioxanone.
Claim 7
Dependent Claim
10 words
A suture of claim 1 comprising a polymer of dimethyl-p-dioxanone.
Claim 8
Dependent Claim
34 words
A suture of claim 1 comprising a copolymer of more than 50% by weight p-dioxanone and less than 50% by weight of at least one other monomer copolymerizable with p-dioxanone to an absorbable polymer.
Claim 9
Dependent Claim
15 words
A suture of claim 7 wherein said copolymer is of p-dioxanone and glycolide or lactide.
Claim 10
Dependent Claim
101 words
A sterile synthetic absorbable suture comprising oriented fiber of a polymer having units of the formula: ##STR5## wherein R' and R are individually hydrogen, methyl, or ethyl and x is the degree of polymerization resulting in a fiber forming polymer, said suture being dry to the extent of being substantially free of moisture, and characterized by a Young's modulus of less than about 600,000 psi with a correspondingly high degree of softness and flexibility, an initial straight tensile and knot strength of at least about 40,000 psi and 30,000 psi respectively, and substantially complete absorption in vivo within about 180 days.
Claim 11
Dependent Claim
101 words
A sterile synthetic absorbable suture comprising oriented fiber of a polymer having units of the formula: ##STR5## wherein R' and R are individually hydrogen, methyl, or ethyl and x is the degree of polymerization resulting in a fiber forming polymer, said suture being dry to the extent of being substantially free of moisture, and characterized by a Young's modulus of less than about 600,000 psi with a correspondingly high degree of softness and flexibility, an initial straight tensile and knot strength of at least about 40,000 psi and 30,000 psi respectively, and substantially complete absorption in vivo within about 180 days.
Claim 12
Dependent Claim
30 words
A suture of claim 9 wherein said polymer is a homopolymer of p-dioxanone having an inherent viscosity of at least 0.50 in a 0.1% solution of tetrachloroethane at 25° C.
Claim 13
Dependent Claim
16 words
A suture of claim 10 wherein the inherent viscosity of said polymer is at least 0.80.
Claim 14
Dependent Claim
35 words
A suture of claim 9 wherein said polymer is a copolymer of more than 50% by weight p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
Claim 15
Dependent Claim
17 words
A suture of claim 12 wherein said polymer is a copolymer of p-dioxanone and lactide or glycolide.
Claim 16
Dependent Claim
39 words
A suture of claim 9 wherein said polymer is a homopolymer of methyl-p-dioxanone or copolymer of more than 50% by weight methyl-p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
Claim 17
Dependent Claim
39 words
A suture of claim 9 wherein said polymer is a homopolymer of dimethyl-p-dioxanone or copolymer of more than 50% by weight dimethyl-p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
Claim 18
Dependent Claim
16 words
A suture of claim 1 having a surgical needle attached to at least one end thereof.
Claim 19
Dependent Claim
24 words
A needle and suture combination of claim 16 packaged in a sterile and dry environment within a hermetically sealed and substantially moisture impervious container.
Claim 20
Dependent Claim
16 words
A suture of claim 9 having a surgical needle attached to at least one end thereof.
Claim 21
Dependent Claim
24 words
A needle and suture combination of claim 18 packaged in a sterile and dry environment within a hermetically sealed and substantially moisture impervious container.
Claim 22
Dependent Claim
108 words
A surgical prosthesis comprising a fabric manufactured at least in part from synthetic absorbable fibers of a polymer having units of the formula: ##STR6## wherein R' and R are individually hydrogen, methyl, or ethyl and x is the degree of polymerization resulting in a fiber forming polymer, said fibers being dry to the extent of being substantially free of moisture, and characterized by a Young's modulus of less than about 600,000 psi with a correspondingly high degree of softness and flexibility, an initial straight tensile and knot strength of at least about 40,000 psi and 30,000 psi respectively, and substantially complete absorption in vivo within about 180 days.
Claim 23
Dependent Claim
108 words
A surgical prosthesis comprising a fabric manufactured at least in part from synthetic absorbable fibers of a polymer having units of the formula: ##STR6## wherein R' and R are individually hydrogen, methyl, or ethyl and x is the degree of polymerization resulting in a fiber forming polymer, said fibers being dry to the extent of being substantially free of moisture, and characterized by a Young's modulus of less than about 600,000 psi with a correspondingly high degree of softness and flexibility, an initial straight tensile and knot strength of at least about 40,000 psi and 30,000 psi respectively, and substantially complete absorption in vivo within about 180 days.
Claim 24
Dependent Claim
41 words
A surgical prosthesis of claim 20 wherein said polymer is a homopolymer of p-dioxanone or a copolymer of more than 50% by weight p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
Claim 25
Dependent Claim
41 words
A surgical prosthesis of claim 20 wherein said polymer is a homopolymer of methyl-p-dioxanone or a copolymer of more than 50% by weight methyl-p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
Claim 26
Dependent Claim
41 words
A surgical prosthesis of claim 20 wherein said polymer is a homopolymer of dimethyl-p-dioxanone or a copolymer of more than 50% by weight dimethyl-p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
Claim 27
Dependent Claim
55 words
A surgical prosthesis comprising a solid surgical aid formed from an absorbable polymer having units of the formula: ##STR7## wherein R' and R are individually hydrogen, methyl, or ethyl and x is the degree of polymerization resulting in a fiber forming polymer, said prosthesis being dry to the extent of being substantially free of moisture.
Claim 28
Dependent Claim
55 words
A surgical prosthesis comprising a solid surgical aid formed from an absorbable polymer having units of the formula: ##STR7## wherein R' and R are individually hydrogen, methyl, or ethyl and x is the degree of polymerization resulting in a fiber forming polymer, said prosthesis being dry to the extent of being substantially free of moisture.
Claim 29
Dependent Claim
31 words
A surgical prosthesis of claim 24 wherein said polymer is a homopolymer of p-dioxanone having an inherent viscosity of at least 0.50 in a 0.1% solution of tetrachloroethane at 25° C.
Claim 30
Dependent Claim
36 words
A surgical prosthesis of claim 24 wherein said polymer is a copolymer of at least 50% by weight p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
Claim 31
Dependent Claim
41 words
A surgical prosthesis of claim 24 wherein said polymer is a homopolymer of methyl-p-dioxanone or a copolymer of more than 50% by weight methyl-p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
Claim 32
Dependent Claim
41 words
A surgical prosthesis of claim 24 wherein said polymer is a homopolymer of dimethyl-p-dioxanone or a copolymer of more than 50% by weight dimethyl-p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
Claim 33
Independent Claim
126 words
A method of closing a wound in living tissue which comprises approximating the edges of the wound with a synthetic absorbable suture consisting of at least one filament of a polymer of a monomer having the formula: ##STR8## wherein R' and R are individually hydrogen, methyl or ethyl, said suture being at least partially embedded in the living tissue, and leaving said suture in said tissue until the embedded suture is absorbed during the healing process, said suture being characterized by a Young's modulus of less than about 600,000 psi with a correspondingly high degree of softness and flexibility, an initial straight tensile and knot strength of at least about 40,000 psi and 30,000 psi respectively, and substantially complete absorption in vivo within about 180 days.
Claim 34
Independent Claim
126 words
A method of closing a wound in living tissue which comprises approximating the edges of the wound with a synthetic absorbable suture consisting of at least one filament of a polymer of a monomer having the formula: ##STR8## wherein R' and R are individually hydrogen, methyl or ethyl, said suture being at least partially embedded in the living tissue, and leaving said suture in said tissue until the embedded suture is absorbed during the healing process, said suture being characterized by a Young's modulus of less than about 600,000 psi with a correspondingly high degree of softness and flexibility, an initial straight tensile and knot strength of at least about 40,000 psi and 30,000 psi respectively, and substantially complete absorption in vivo within about 180 days.
Claim 35
Dependent Claim
16 words
A method of claim 29 wherein R and R' are hydrogen and the monomer is p-dioxanone.
Claim 36
Dependent Claim
10 words
A method of claim 29 wherein the monomer is methyl-p-dioxanone.
Claim 37
Dependent Claim
10 words
A method of claim 29 wherein the monomer is dimethyl-p-dioxanone.
Claim 38
Independent Claim
138 words
A method of closing a wound in living tissue which comprises approximating the edge of the wound with a synthetic absorbable suture consisting of at least one filament of a polymer having units of the formula: ##STR9## wherein R' and R are individually hydrogen, methyl or ethyl, and x is the degree of polymerization resulting in a fiber forming polymer, said suture being at least partially embedded in the living tissue, and leaving said suture in said tissue until the embedded suture is absorbed during the healing process, said suture being characterized by a Young's modulus of less than about 600,000 psi with a correspondingly high degree of softness and flexibility, an initial straight tensile and knot strength of at least about 40,000 psi and 30,000 psi respectively, and substantially complete absorption in vivo within about 180 days.
Claim 39
Independent Claim
138 words
A method of closing a wound in living tissue which comprises approximating the edge of the wound with a synthetic absorbable suture consisting of at least one filament of a polymer having units of the formula: ##STR9## wherein R' and R are individually hydrogen, methyl or ethyl, and x is the degree of polymerization resulting in a fiber forming polymer, said suture being at least partially embedded in the living tissue, and leaving said suture in said tissue until the embedded suture is absorbed during the healing process, said suture being characterized by a Young's modulus of less than about 600,000 psi with a correspondingly high degree of softness and flexibility, an initial straight tensile and knot strength of at least about 40,000 psi and 30,000 psi respectively, and substantially complete absorption in vivo within about 180 days.
Claim 40
Dependent Claim
31 words
A method of claim 33 wherein said polymer is a homopolymer of p-dioxanone having an inherent viscosity of at least 0.50 in a 0.1 percent solution of tetrachloroethane at 25° C.
Claim 41
Dependent Claim
16 words
A method of claim 34 wherein the inherent viscosity of said polymer is at least 0.80.
Claim 42
Dependent Claim
35 words
A method of claim 33 wherein said polymer is a copolymer of more than 50% by weight p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
Claim 43
Dependent Claim
17 words
A method of claim 36 wherein said polymer is a copolymer of p-dioxanone and lactide or glycolide.
Claim 44
Dependent Claim
40 words
A method of claim 33 wherein said polymer is a homopolymer of methyl-p-dioxanone or a copolymer of more than 50% by weight methyl-p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
Claim 45
Dependent Claim
40 words
A method of claim 33 wherein said polymer is a homopolymer of dimethyl-p-dioxanone or a copolymer of more than 50% by weight dimethyl-p-dioxanone with less than 50% by weight of at least one other monomer copolymerizable to an absorbable polymer.
References Cited (Backward Citations)
US3063967A
Cited
US3190858A
Cited
US3063968A
Cited
US3297033A
Cited
US3645941A
Cited
US3636956A
Cited
US3867190A
Cited
US3960152A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-10 | 1981-04-11 | 1981-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-10 | 1985-04-11 | 1985-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-10 | 1989-04-11 | 1989-10-11 | $7700.00 | Window Closed / Lapsed |