Phosphinylalkanoyl imino acids

Claim 1

A compound represented by the formula ##STR26## wherein X is ##STR27## D is ##STR28## or a bond; m, n, and r are independently 0-14; x is 1-4; p and q are independently 0 or 1, provided that the sum of p and q is 1 or 2; s is 2 or 3; t is 1-3; R is hydrogen, lower alkyl, halogen-substituted lower alkyl, cycloloweralkyl, --(CH 2 ) u -cycloloweralkyl, or --(CH 2 ) v --C 6 H 5 , wherein u is 1-4 and v is 0-4; R 1 is hydroxy, alkoxy having from 1 to 8 carbon atoms, phenylloweralkoxy, allyloxy, R 9 --Q w --(CH 2 ) y --O--, wherein Q is oxygen or sulfur, w is 0 or 1 and y is 2 to 4, ##STR29## wherein the alkyl has from 3 to 8 carbon atoms, ##STR30## wherein the phenyl may be substituted with group T defined below, 1-glyceryl, ##STR31## R 2 is R or heterocycloloweralkyl, wherein heterocyclo is a 5- or 6-membered aliphatic or aromatic ring of 3 to 5 carbon atoms and 1 to 3 heteroatoms selected from nitrogen, sulfur and oxygen; R 3 is hydrogen or lower alkyl; R 4 and R 5 are independently hydrogen, lower alkyl or cycloloweralkyl, or R 4 and R 5 together with the carbon atoms to which they are attached form a 5- or 6-membered ring; R 6 and R 7 are independently hydrogen, lower alkyl or cycloloweralkyl, or R 6 and R 7 together with the nitrogen and carbon atoms to which they are attached form a 4-, 6-, 7- or 8-membered ring; R 8 is R 1 , amino, hydroxylamino, mono- or disubstituted amino wherein the substituents are lower alkyl, phenyl or phenylloweralkyl, and wherein the phenyl may be substituted with group T defined below; R 9 is phenyl, substituted phenyl wherein the substituents are chosen from group T, 1-naphthyl or 2-naphthyl; T is halogen, hydroxy, trifluoromethyl, lower alkoxy, lower alkyl, 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, phenyl and substituted phenyl wherein the substituents are chosen from halogen, hydroxy, trifluoromethyl, lower alkoxy or lower alkyl; R 10 is hydrogen or alkyl having from 1 to 8 carbon atoms; R 11 is hydrogen, lower alkyl, unsubstituted or substituted phenyl and substituted or unsubstituted phenylloweralkyl wherein phenyl may be substituted by group T; R 12 is hydrogen or lower alkyl; R 13 is chloro or trifluoromethyl; or a pharmaceutically acceptable salt thereof.