US4431645A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antihypertensive agents
Assignee: Merck Sharp & Dohme LLC
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Filing: 1982-03-08
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Granted: 1984-02-14
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Expires: 2002-03-08
Abstract
Abstract Compounds of the formula <IMAGE> I and the pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are independently selected from hydrogen or lower alkyl; n is 1 or 0; A and B taken together with the carbons to which they are attached form an alkylene ring having six carbon atoms or A and B are hydrogen; and Z is <IMAGE> <IMAGE> +TR <IMAGE> The compounds are useful as hypertensive agents.
Inventors
- 👤 Elizabeth M. Smith
- 👤 Joseph T. Witkowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 23:00
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/02; C07K5/022; C07K5/0222; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
68 words
A compound of the formula ##STR17## or a pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 and R 4 are independently selected from hydrogen or lower alkyl; n is 1 or 0; A and B taken together with the carbons to which they are attached form an alkylene ring having six carbon atoms or A and B are hydrogen; and Z is ##STR18##
Claim 2
Dependent Claim
68 words
A compound of the formula ##STR17## or a pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 and R 4 are independently selected from hydrogen or lower alkyl; n is 1 or 0; A and B taken together with the carbons to which they are attached form an alkylene ring having six carbon atoms or A and B are hydrogen; and Z is ##STR18##
Claim 3
Dependent Claim
10 words
A compound according to claim 1, wherein n is 0.
Claim 4
Dependent Claim
11 words
A compound according to claim 1, wherein R 3 is hydrogen.
Claim 5
Dependent Claim
11 words
A compound according to claim 1, wherein R 2 is hydrogen.
Claim 6
Dependent Claim
11 words
A compound according to claim 1, wherein R 4 is hydrogen.
Claim 7
Dependent Claim
19 words
A compound according to claim 5, wherein n is 0, R 2 is hydrogen and R 3 is hydrogen.
Claim 8
Dependent Claim
29 words
A compound according to claim 1, wherein A and B taken together with the carbon atoms to which they are attached form an alkylene ring having six carbon atoms.
Claim 9
Dependent Claim
10 words
A compound according to claim 7, wherein n is 0.
Claim 10
Dependent Claim
11 words
A compound according to claim 7, wherein R 2 is hydrogen.
Claim 11
Dependent Claim
11 words
A compound according to claim 7, wherein R 3 is hydrogen.
Claim 12
Dependent Claim
11 words
A compound according to claim 7, wherein R 4 is hydrogen.
Claim 13
Dependent Claim
19 words
A compound according to claim 11, wherein n is 0, R 2 is hydrogen and R 3 is hydrogen.
Claim 14
Dependent Claim
12 words
A compound according to claim 1 or 12 wherein Z is ##STR19##
Claim 15
Dependent Claim
12 words
A compound according to claim 1 or 12 wherein Z is ##STR20##
Claim 16
Dependent Claim
12 words
A compound according to claim 1 or 12 wherein Z is ##STR21##
Claim 17
Dependent Claim
28 words
A method of treating hypertension in mammals comprising administering to a mammal in need of such treatment an antihypertensive effective amount of a compound according to claim 1.
Claim 18
Dependent Claim
15 words
A pharmaceutical composition comprising an antihypertensive effective amount of a compound according to claim 1.
References Cited (Backward Citations)
US3110716A
Cited
GB2073187A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-13 | 1987-08-15 | 1988-02-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-13 | 1991-08-15 | 1992-02-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-13 | 1995-08-15 | 1996-02-14 | $7700.00 | Window Closed / Lapsed |