Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors

Claim 1

A compound having the formula ##STR24## or a salt thereof, wherein R 1 is hydrogen, aryl or heteroaryl; R 2 is hydrogen, amino, alkanoylamino, arylcarbonylamino, or heteroarylcarbonylamino; R 3 is hydrogen, alkyl, or aminoalkyl, R 4 and R 5 are the same or different and each is hydrogen, alkyl, halogen, aryl, arylalkyl, hydroxy, alkoxy, alkylthio, aryloxy, arylthio, or cycloalkyl, or R 4 and R 5 taken together are oxo, ethylenedithio or propylenedithio; R 6 is hydrogen, alkyl or aryl; R 8 is hydrogen, alkyl or aryl; R 9 is hydrogen or alkyl; n is 0 or an integer of 1 to 8; m is 0 or 1; and A is --(CH 2 ) p -- wherein p is 0 or 1, --NH--, or --O--; wherein the term "aryl" refers to phenyl or phenyl substituted with halogen, alkyl, alkoxy, alkylthio, hydroxy, alkanoyl, nitro, amino, dialkylamino, or trifluoromethyl groups; the term "alkyl" refers to groups having 1 to 10 carbon atoms; the term "alkoxy" refers to groups having 1 to 8 carbon atoms; the term "alkanoyl" refers to groups having 2 to 10 carbon atoms; and the term "heteroaryl" refers to pyridyl, furyl, thienyl, pyrimidinyl, quinolyl, indolyl, benzothiophenyl, benzothiazolyl, purinyl, benzoxazolyl, or thiazolyl.