US4581231A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inactivation of viruses containing essential lipids
Assignee: United States, REPRSENTED BY SECRETARY OF DEPARTMENT OF HEALTH AND HUMAN SERVICES
•
Filing: 1983-08-31
•
Granted: 1986-04-08
•
Expires: 2003-08-31
Abstract
Abstract A method of inactivating a lipid virus in a protein carrier by contacting said virus for an abbreviated period of time and ambient temperature with a halohydrocarbon solvent or treating agent, preferably chloroform, in an amount of 5% v/v to 50% v/v. Preferred lipid viruses are Hepatitis B virus (HBV) and non-A, non-B Hepatitis (NANBH).
Inventors
- 👤 Robert H. Purcell
- 👤 Stephen M. Feinstone
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 20:00
CPC Classifications
C; C12; C12N; C12N7/00; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61K38/00; A61K38/16; A61K38/17; A61K38/36; A61K38/37; A61K39/00; A61K39/12; A61K39/29; A61L; A61L2/00; A61L2/16; A61L2/18; A61L2103/00; A61L2103/05; C12N2730/00; C12N2730/00011; C12N2730/10011; C12N2730/10111; C12N2730/10134; C12N2730/10161; C12N2730/10163; C12N2770/00; C12N2770/00011; C12N2770/24011; C12N2770/24211; C12N2770/24261; C12N2770/24263
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
56 words
A method of inactivating lipid viruses in blood plasma products consisting of treating said products prior to use with a treating agent selected from the group consisting of chloroform, a chloroform/lower alkanol mixure, a fluorochloro alkane and ethylene dichloride for at least about 10 minutes at a temperature of between 4°-40° C. and at 5-50% v/v.
Claim 2
Independent Claim
56 words
A method of inactivating lipid viruses in blood plasma products consisting of treating said products prior to use with a treating agent selected from the group consisting of chloroform, a chloroform/lower alkanol mixure, a fluorochloro alkane and ethylene dichloride for at least about 10 minutes at a temperature of between 4°-40° C. and at 5-50% v/v.
Claim 3
Dependent Claim
12 words
A method according to claim 1 wherein the treating agent is chloroform.
Claim 4
Dependent Claim
14 words
A method according to claim 1 wherein the treating agent is a chloroform/methanol mixture.
Claim 5
Dependent Claim
13 words
A method according to claim 1 wherein the treating agent is ethylene dichloride.
References Cited (Backward Citations)
US2798836A
Cited
US3847737A
Cited
US4139630A
Cited
US4113712A
Cited
US4031204A
Cited
US4302444A
Cited
US4291020A
Cited
US4314997A
Cited
US4315919A
Cited
US4446134A
Cited
US4481189A
Cited
US4431633A
Cited
US4511556A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-07 | 1989-10-07 | 1990-04-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-07 | 1993-10-07 | 1994-04-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-07 | 1997-10-07 | 1998-04-08 | $7700.00 | Window Closed / Lapsed |