US4031204A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Feline viral rhinotracheitis vaccine and combination feline viral rhinotracheitis-calicivirus vaccine prepared therefrom
Assignee: SmithKline Beecham Corp
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Filing: 1976-03-30
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Granted: 1977-06-21
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Expires: 1996-03-30
Abstract
Abstract A modified live feline viral rhinotracheitis vaccine is prepared by treating with ultraviolet light a feline viral rhinotracheitis virus which has been subjected to chemical treatment with mutagens. A combination feline viral rhinotracheitis-calicivirus vaccine is prepared by combining a modified live feline viral rhinotracheitis virus and naturally-occurring calicivirus.
Inventors
- 👤 Eldon Davis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 13:04
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/02; A61K; A61K39/00; A61K39/12; A61K39/245; A61K39/265; A61L2/08; A61L2/10; A61K2039/51; A61K2039/525; A61K2039/5254; A61K2039/55; A61K2039/552; A61K2039/70; A61L2103/00; A61L2103/05; C; C12; C12N; C12N2710/00; C12N2710/00011; C12N2710/16011; C12N2710/16711; C12N2710/16734; C12N2770/00; C12N2770/00011; C12N2770/16011; C12N2770/16034; Y; Y10; Y10S; Y10S424/00; Y10S424/819
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
84 words
A modified live feline viral rhinotracheitis vaccine capable of inducing immunity in animals of the genus felidae without serious side effects comprising a modified live feline viral rhinotracheitis virus prepared by treating a feline viral rhinotracheitis virus which has been chemically modified by treatment with DNA inhibitor(s) so that said virus grows well at 30° C ± 2° C but not at 39° C with ultraviolet light until from about 90% to about 99% of the virus particles are killed, and a carrier therefor.
Claim 2
Dependent Claim
84 words
A modified live feline viral rhinotracheitis vaccine capable of inducing immunity in animals of the genus felidae without serious side effects comprising a modified live feline viral rhinotracheitis virus prepared by treating a feline viral rhinotracheitis virus which has been chemically modified by treatment with DNA inhibitor(s) so that said virus grows well at 30° C ± 2° C but not at 39° C with ultraviolet light until from about 90% to about 99% of the virus particles are killed, and a carrier therefor.
Claim 3
Dependent Claim
36 words
The modified live feline viral rhinotracheitis vaccine of claim 1 where the chemically modified feline viral rhinotracheitis virus is treated with ultraviolet light until from about 95% to about 99% of the virus particles are killed.
Claim 4
Dependent Claim
54 words
The modified live feline viral rhinotracheitis vaccine of claim 2 where the chemically modified feline viral rhinotracheitis virus is treated with ultraviolet light until about 99% of the virus particles are killed and the treated virus is then passaged at least once in cells of the genus felidae at 30° C ± 2° C.
Claim 5
Dependent Claim
38 words
The modified live feline viral rhinotracheitis vaccine of claim 3 where the ultraviolet treated virus is passaged in feline kidney cells containing from about 2% to about 10% homologous or heterologous serum at 30° C ± 2° C.
Claim 6
Dependent Claim
39 words
The modified live feline viral rhinotracheitis vaccine of claim 4 where the treated virus is passaged 10 to 12 times in stable feline kidney cells containing from about 2% to about 10% of foetal calf serum at 31° C.
Claim 7
Dependent Claim
23 words
The modified live feline viral rhinotracheitis vaccine of claim 5 where the chemically modified feline viral rhinotracheitis virus is ATCC No. VR 814.
Claim 8
Dependent Claim
31 words
The modified live feline viral rhinotracheitis vaccine of claim 1 where the virus titer is from about 10 5 .0 TCID 50 to about 10 8 .0 TCID 50 per dose.
Claim 9
Dependent Claim
60 words
A process for preparing the modified live feline viral rhinotracheitis vaccine of claim 1 which comprises treating a feline viral rhinotracheitis virus which has been chemically modified so that said virus grows well at 30° C ± 2° C but not at 39° C with ultraviolet light until from about 90% to about 99% of the virus particles are killed.
Claim 10
Dependent Claim
31 words
The process of claim 8 where the chemically modified feline viral rhinotracheitis virus is treated with ultraviolet light until from about 95% to about 99% of the virus particles are killed.
Claim 11
Dependent Claim
49 words
The process of claim 9 where the chemically modified feline viral rhinotracheitis virus is treated with ultraviolet light until about 99% of the virus particles are killed and the treated virus is then passaged at least once in cells of the genus felidae at 30° C ± 2° C.
Claim 12
Dependent Claim
33 words
The process of claim 10 where the ultraviolet treated virus is passaged in feline kidney cells containing from about 2% to about 10% homologous or heterologous serum at 30° C ± 2° C.
Claim 13
Dependent Claim
34 words
The process of claim 11 where the treated virus is passaged ten to twelve times in stable feline kidney cells containing from about 2% to about 10% of foetal calf serum at 31° C.
Claim 14
Dependent Claim
18 words
The process of claim 8 where the chemically modified feline viral rhinotracheitis virus is ATCC No. VR 814.
Claim 15
Dependent Claim
66 words
A process for preparing a further quantity of modified live feline viral rhinotracheitis virus comprising further growing a modified live feline viral rhinotracheitis virus as claimed in claim 1 in feline kidney cells at 30° C ± 2° C, said further growth being for a length of time sufficient to permit growth of a larger amount of said virus and then harvesting the resultant viral material.
Claim 16
Dependent Claim
17 words
The process of claim 14 where the modified live feline viral rhinotracheitis virus is ATCC No. VR-815.
Claim 17
Dependent Claim
33 words
The process of claim 14 where the modified live feline viral rhinotracheitis virus is grown in stable feline kidney cells containing from about 2% to about 10% of foetal calf serum at 31°.
Claim 18
Dependent Claim
24 words
A method of vaccinating animals of the genus felidae comprising administering to said animals the modified live feline viral rhinotracheitis vaccine of claim 1.
Claim 19
Dependent Claim
16 words
The method of claim 17 where the modified live feline viral rhinotracheitis vaccine is administered intranasally.
Claim 20
Dependent Claim
16 words
The method of claim 17 where the modified live feline viral rhinotracheitis vaccine is administered intraocularly.
Claim 21
Dependent Claim
19 words
The method of claim 17 where the modified live feline viral rhinotracheitis vaccine is administered both intranasally and intraocularly.
Claim 22
Dependent Claim
43 words
A combination modified live feline viral rhinotracheitis-calicivirus vaccine capable of inducing immunity in animals of the genus felidae without serious side effects comprising a modified live feline viral rhinotracheitis virus obtained as in claim 1, a vaccinal feline calicivirus and a carrier therefor.
Claim 23
Dependent Claim
43 words
A combination modified live feline viral rhinotracheitis-calicivirus vaccine capable of inducing immunity in animals of the genus felidae without serious side effects comprising a modified live feline viral rhinotracheitis virus obtained as in claim 5, a vaccinal feline calicivirus and a carrier therefor.
Claim 24
Dependent Claim
43 words
A combination modified live feline viral rhinotracheitis-calicivirus vaccine capable of inducing immunity in animals of the genus felidae without serious side effects comprising a modified live feline viral rhinotracheitis virus obtained as in claim 6, a vaccinal feline calicivirus and a carrier therefor.
Claim 25
Dependent Claim
26 words
The combination feline viral rhinotracheitis-calicivirus vaccine of claim 21 where the modified live feline viral rhinotracheitis virus and the calicivirus are present in a 1:1 ratio.
Claim 26
Dependent Claim
23 words
A method of vaccinating animals of the genus felidae comprising administering to said animals the combination feline viral rhinotracheitis-calicivirus vaccine of claim 21.
Claim 27
Dependent Claim
15 words
The method of claim 25 where the combination feline viral rhinotracheitis-calicivirus vaccine is administered intranasally.
Claim 28
Dependent Claim
15 words
The method of claim 25 where the combination feline viral rhinotracheitis-calicivirus vaccine is administered intraocularly.
Claim 29
Dependent Claim
18 words
The method of claim 25 where the combination feline viral rhinotracheitis-calicivirus vaccine is administered both intranasally and intraocularly.
References Cited (Backward Citations)
US3259546A
Cited
US3914408A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-20 | 1980-12-20 | 1981-06-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-20 | 1984-12-20 | 1985-06-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-20 | 1988-12-20 | 1989-06-21 | $7700.00 | Window Closed / Lapsed |