US6692458B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis
Assignee: Edwards Lifesciences Corp
•
Filing: 2000-12-19
•
Granted: 2004-02-17
•
Expires: 2020-12-19
Abstract
Abstract A catheter and a method for using the catheter for site specific delivery of agents to or collecting agents from biological spaces. The catheter includes an inner shaft longitudinally movable within an outer shaft, each shaft having at least one balloon and at least one lumen formed therein. The catheter prevents leaking through a biological membrane by sealing the catheter tip passageway through the biological membrane with inflatable balloons on either side of the biological membrane. Further, the inflated balloons secure the position of the catheter relative to the biological membrane and the biological space targeted for therapy or diagnosis.
Inventors
- 👤 Michael Robert Forman
- 👤 Donald E. Bobo, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:07
CPC Classifications
A; A61; A61M; A61M25/00; A61M25/01; A61M25/06; A61M25/065; A61M25/0067; A61M25/0082; A61M25/0084; A61M25/02; A61M25/04; A61M2025/0089; A61M2025/0213; A61M2025/0233; A61M2210/00; A61M2210/12; A61M2210/125; A61M25/0105; A61M25/0108; A61M25/10; A61M25/1011
Claims Analysis
Total Claims: 59
Claim 1
Independent Claim
98 words
A catheter for delivering agents to a defined biological space in vivo comprising: an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip configured to pierce a biological membrane proximate to the biological space; an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip; said inner catheter shaft longitudinally movable within and with respect to said outer catheter shaft; and at least one deployable support member non-detachably secured to at least one of said inner catheter shaft and said outer catheter shaft.
Claim 2
Dependent Claim
98 words
A catheter for delivering agents to a defined biological space in vivo comprising: an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip configured to pierce a biological membrane proximate to the biological space; an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip; said inner catheter shaft longitudinally movable within and with respect to said outer catheter shaft; and at least one deployable support member non-detachably secured to at least one of said inner catheter shaft and said outer catheter shaft.
Claim 3
Dependent Claim
39 words
A catheter of claim 1 , wherein said at least one deployable support member comprises at least one inflatable balloon in communication with at least one of said lumens of said inner catheter shaft or said outer catheter shaft.
Claim 4
Dependent Claim
38 words
A catheter of claim 2 , wherein said at least one deployable support member comprises said at least one inflatable balloon disposed on said inner catheter shaft and in communication with said at least one inner shaft lumen.
Claim 5
Dependent Claim
38 words
A catheter of claim 2 , wherein said at least one deployable support member comprises said at least one inflatable balloon disposed on said outer catheter shaft and in communication with said at least one outer shaft lumen.
Claim 6
Dependent Claim
70 words
A catheter of claim 2 , wherein said at least one deployable support member comprises said at least one inflatable balloon disposed on said inner catheter shaft and in communication with said at least one inner shaft lumen, and said at least one deployable support member comprises said at least one inflatable balloon disposed on said outer catheter shaft and in communication with said at least one outer shaft lumen.
Claim 7
Dependent Claim
38 words
A catheter of claim 1 , wherein said at least one deployable support member comprises at least one deployable wire support in communication with at least one of said lumens of said inner shaft or said outer shaft.
Claim 8
Dependent Claim
38 words
A catheter of claim 6 , wherein said at least one deployable support member comprises said at least one deployable wire support disposed on said inner shaft and in communication with said at least one inner shaft lumen.
Claim 9
Dependent Claim
38 words
A catheter of claim 6 , wherein said at least one deployable support member comprises said at least one deployable wire support disposed on said outer shaft and in communication with said at least one outer shaft lumen.
Claim 10
Dependent Claim
70 words
A catheter of claim 6 , wherein said at least one deployable support member comprises said at least one deployable wire support disposed on said inner shaft and in communication with said at least one inner shaft lumen, and said at least one deployable support member comprises said at least one deployable wire support disposed on said outer shaft and in communication with said at least one outer shaft lumen.
Claim 11
Dependent Claim
15 words
A catheter of claim 1 , wherein said inner shaft distal tip is a needle.
Claim 12
Dependent Claim
50 words
The catheter of claim 1 , wherein said catheter comprises at least one port positioned proximate to the proximal portion of said catheter and in communication with one of said lumens in said inner catheter shaft, and wherein said lumen is for delivery of an agent to a biological space.
Claim 13
Dependent Claim
13 words
A catheter of claim 11 , wherein the agent is a therapeutic agent.
Claim 14
Dependent Claim
13 words
A catheter of claim 11 , wherein the agent is an angiogenic agent.
Claim 15
Dependent Claim
48 words
A catheter of claim 11 , wherein said at least one port is in communication with at least one of said lumens of said inner catheter shaft and said outer catheter shaft and wherein at least one of said lumens is for the inflation of said inflatable balloon.
Claim 16
Dependent Claim
46 words
A catheter of claim 11 wherein said at least one port is in communication with at least one of said lumens of said inner shaft or said outer shaft and wherein at least one of said lumens is for the deployment of said deployable wire support.
Claim 17
Dependent Claim
34 words
A catheter of claim 1 , wherein said inner shaft distal tip has orifices formed therein for the delivery of an agent from said lumen of said inner catheter shaft to the biological space.
Claim 18
Dependent Claim
32 words
A catheter of claim 1 further comprising at least one inflatable sealing balloon in communication with at least one of said lumens of said inner catheter shaft or said outer catheter shaft.
Claim 19
Dependent Claim
30 words
A catheter of claim 17 , further comprising at least one inflatable balloon positioned on said inner catheter shaft and in communication with said at least one inner shaft lumen.
Claim 20
Dependent Claim
57 words
A catheter of claim 17 , wherein said catheter disposes said at least one deployable support member comprising at least one inflatable balloon in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said inner shaft and in communication with said at least one inner shaft lumen.
Claim 21
Dependent Claim
57 words
A catheter of claim 17 , wherein said catheter disposes said at least one deployable support member comprising at least one inflatable balloon in communication with at least one said inner shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen.
Claim 22
Dependent Claim
30 words
A catheter of claim 17 , further comprising at least one inflatable balloon positioned on said outer catheter shaft and in communication with said at least one outer shaft lumen.
Claim 23
Dependent Claim
53 words
A catheter of claim 17 , further comprising at least one inflatable balloon positioned on said inner catheter shaft and in communication with said at least one inner shaft lumen, and at least one inflatable balloon positioned on said outer catheter shaft and in communication with said at least one outer shaft lumen.
Claim 24
Dependent Claim
106 words
A catheter of claim 17 , wherein said catheter disposes said at least one deployable support member comprising at least one inflatable balloon in communication with at least one said inner shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen, and disposing said at least one deployable support member comprising at least one inflatable balloon in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen.
Claim 25
Dependent Claim
54 words
A catheter of claim 17 , further comprising at least one deployable wire support in communication with at least one of said inner catheter shaft and said outer catheter shaft and having said at least one inflatable sealing balloon disposed on at least one of said inner catheter shaft and said outer catheter shaft.
Claim 26
Dependent Claim
58 words
A catheter of claim 17 , wherein said catheter disposes said at least one deployable support member comprising at least one deployable wire support in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said inner shaft and in communication with said at least one inner shaft lumen.
Claim 27
Dependent Claim
58 words
A catheter of claim 17 , wherein said catheter disposes said at least one deployable support member comprising at least one deployable wire support in communication with at least one said inner shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen.
Claim 28
Dependent Claim
58 words
A catheter of claim 17 , wherein said catheter disposes said at least one deployable support member comprising at least one deployable wire support in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen.
Claim 29
Dependent Claim
108 words
A catheter of claim 17 , wherein said catheter disposes said at least one deployable support member comprising at least one deployable wire support in communication with at least one said inner shaft and having said at least one inflatable sealing balloon disposed on said inner shaft and in communication with said at least one inner shaft lumen, and disposing said at least one deployable support member comprising at least one deployable wire support in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen.
Claim 30
Dependent Claim
108 words
A catheter of claim 17 , wherein said catheter disposes said at least one deployable support member comprising at least one deployable wire support in communication with at least one said inner shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen, and disposing said at least one deployable support member comprising at least one deployable wire support in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen.
Claim 31
Dependent Claim
120 words
A catheter for delivering agents to a defined biological space in vivo comprising: an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip; an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip; said inner catheter shaft longitudinally movable within and with respect to said outer catheter shaft; said outer catheter shaft comprising a proximal pusher portion and a distal end portion, said proximal pusher portion configured to be retractable from said distal end portion to uncover said inner catheter shaft; and at least one deployable support member non-detachably attached to at least one of said inner catheter shaft and said outer catheter shaft.
Claim 32
Dependent Claim
120 words
A catheter for delivering agents to a defined biological space in vivo comprising: an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip; an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip; said inner catheter shaft longitudinally movable within and with respect to said outer catheter shaft; said outer catheter shaft comprising a proximal pusher portion and a distal end portion, said proximal pusher portion configured to be retractable from said distal end portion to uncover said inner catheter shaft; and at least one deployable support member non-detachably attached to at least one of said inner catheter shaft and said outer catheter shaft.
Claim 33
Independent Claim
150 words
A method for delivering agents to a defined biological space in vivo comprising: providing a catheter comprising an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip, and having an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip, said inner catheter shaft disposed within and movable with respect said outer catheter shaft and disposing at least one deployable support member non-detachable positioned on at least one of said inner catheter shaft and said outer catheter shaft; guiding said catheter to a surface of the biological space in vivo; piercing a surface membrane of the biological space with said inner catheter distal tip; deploying said at least one deployable support member; infusing an agent into the biological space; retracting said at least one deployable support member; and withdrawing said catheter from said biological space.
Claim 34
Independent Claim
150 words
A method for delivering agents to a defined biological space in vivo comprising: providing a catheter comprising an outer catheter shaft defining at least one outer shaft lumen and having an outer shaft distal tip, and having an inner catheter shaft defining at least one inner shaft lumen and having an inner shaft distal tip, said inner catheter shaft disposed within and movable with respect said outer catheter shaft and disposing at least one deployable support member non-detachable positioned on at least one of said inner catheter shaft and said outer catheter shaft; guiding said catheter to a surface of the biological space in vivo; piercing a surface membrane of the biological space with said inner catheter distal tip; deploying said at least one deployable support member; infusing an agent into the biological space; retracting said at least one deployable support member; and withdrawing said catheter from said biological space.
Claim 35
Dependent Claim
36 words
The method of claim 31 , wherein said deployable support member comprises at least one inflatable balloon in communication with at least one of said lumens of said inner catheter shaft or said outer catheter shaft.
Claim 36
Dependent Claim
33 words
The method of claim 32 , wherein said deployable support member comprises at least one inflatable balloon positioned on said inner catheter shaft and in communication with at least one inner shaft lumen.
Claim 37
Dependent Claim
33 words
The method of claim 32 , wherein said deployable support member comprises at least one inflatable balloon positioned on said outer catheter shaft and in communication with at least one outer shaft lumen.
Claim 38
Dependent Claim
55 words
The method of claim 32 , wherein said deployable support member comprises at least one inflatable balloon positioned on said inner catheter shaft and in communication with at least one inner shaft lumen and at least one inflatable balloon positioned on said outer catheter shaft and in communication with at least one outer shaft lumen.
Claim 39
Dependent Claim
35 words
The method of claim 31 , wherein said deployable support member comprises at least one deployable wire support in communication with at least one of said lumens of said inner shaft or said outer shaft.
Claim 40
Dependent Claim
30 words
The method of claim 36 , wherein said deployable support member comprises at least one deployable wire support disposed on and in communication with at least one inner shaft lumen.
Claim 41
Dependent Claim
30 words
The method of claim 36 , wherein said deployable support member comprises at least one deployable wire support disposed on and in communication with at least one outer shaft lumen.
Claim 42
Dependent Claim
56 words
The method of claim 36 , wherein said deployable support member comprises at least one deployable wire support disposed on and in communication with at least one inner shaft lumen, and at least one deployable support member comprises at least one deployable wire support disposed on and in communication with at least one outer shaft lumen.
Claim 43
Dependent Claim
14 words
The method of claim 31 , wherein the biological space is the pericardial space.
Claim 44
Dependent Claim
14 words
The method of claim 31 , wherein the biological agent is a therapeutic agent.
Claim 45
Dependent Claim
14 words
The method of claim 31 , wherein the biological agent is an angiogenic agent.
Claim 46
Dependent Claim
34 words
The method of claim 31 , further comprising inflating at least one inflatable sealing balloon in communication with at least one of said lumens of said inner catheter shaft or said outer catheter shaft.
Claim 47
Dependent Claim
20 words
The method of claim 43 , further comprising inflating at least one inflatable balloon positioned on said inner catheter shaft.
Claim 48
Dependent Claim
20 words
The method of claim 43 , further comprising inflating at least one inflatable balloon positioned on said outer catheter shaft.
Claim 49
Dependent Claim
57 words
The method of claim 43 , further comprising inflating at least one inflatable balloon positioned on said inner catheter shaft and at least one inflatable balloon positioned on said outer catheter shaft and in communication with said at least one outer shaft lumen, thereby providing a supported and isolated infusion of an agent into a biological space.
Claim 50
Dependent Claim
67 words
The method of claim 43 , further comprising inflating a deployable support member comprising at least one inflatable balloon in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen, thereby providing a supported and isolated infusion of an agent into a biological space.
Claim 51
Dependent Claim
119 words
The method of claim 43 , further comprising inflating said at least one deployable support member comprising at least one inflatable balloon in communication with at least one said inner shaft and having said at least one inflatable sealing balloon disposed on said inner shaft and in communication with said at least one inner shaft lumen, and disposing said at least one deployable support member comprising at least one inflatable balloon in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen, thereby providing a supported and isolated infusion of an agent into a biological space.
Claim 52
Dependent Claim
119 words
The method of claim 43 , further comprising inflating said at least one deployable support member comprising at least one inflatable balloon in communication with at least one said inner shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen, and disposing said at least one deployable support member comprising at least one inflatable balloon in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen, thereby providing a supported and isolated infusion of an agent into a biological space.
Claim 53
Dependent Claim
68 words
The method of claim 43 , further comprising deploying a deployable support member comprising at least one deployable wire support in communication with at least one said inner shaft and having said at least one inflatable sealing balloon disposed on said inner shaft and in communication with said at least one inner shaft lumen, thereby providing a supported and isolated infusion of an agent into a biological space.
Claim 54
Dependent Claim
68 words
The method of claim 43 , further comprising deploying a deployable support member comprising at least one deployable wire support in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said inner shaft and in communication with said at least one inner shaft lumen, thereby providing a supported and isolated infusion of an agent into a biological space.
Claim 55
Dependent Claim
68 words
The method of claim 43 , further comprising deploying a deployable support member comprising at least one deployable wire support in communication with at least one said inner shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen, thereby providing a supported and isolated infusion of an agent into a biological space.
Claim 56
Dependent Claim
68 words
The method of claim 43 , further comprising deploying a deployable support member comprising at least one deployable wire support in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen, thereby providing a supported and isolated infusion of an agent into a biological space.
Claim 57
Dependent Claim
121 words
The method of claim 43 , further comprising deploying said at least one deployable support member comprising at least one deployable wire support in communication with at least one said inner shaft and having said at least one inflatable sealing balloon disposed on said inner shaft and in communication with said at least one inner shaft lumen, and disposing said at least one deployable support member comprising at least one deployable wire support in communication with at least one said outer shaft and having said at least one inflatable sealing balloon disposed on said outer shaft and in communication with said at least one outer shaft lumen, thereby providing a supported and isolated infusion of an agent into a biological space.
Claim 58
Dependent Claim
29 words
The method of claim 43 , further comprising: deploying positioned on said inner catheter shaft; and inflating at least one inflatable sealing balloon positioned on said outer catheter shaft.
Claim 59
Dependent Claim
37 words
The method of claim 31 , wherein said catheter further comprises a proximal pusher portion and a distal end portion and said proximal portion is retractable from said distal end portion to uncover said inner catheter shaft.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2007-02-16 | 2007-08-18 | 2008-02-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2011-02-16 | 2011-08-18 | 2012-02-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2015-02-16 | 2015-08-18 | 2016-02-17 | $7700.00 | Window Closed / Lapsed |